Abstract: An instrument guiding trajectory guide can include a ball-and-socket motion constrained by an arch. Z-height adjustment of a trajectory guide lumen can be provided, with or without a ball-and-socket, such as to permit target-centered alignment of the trajectory to a target. A polar-offset or x-y stage can be included. Contrast-enhanced imageable fiducial marker concentric rings can be used to help align the trajectory to the target. The concentric rings can be progressively smaller in a direction along the trajectory.

Abstract: A trajectory guide for introducing an instrument into a human or animal subject is described. A guide stem can be removed in sections without disturbing the aligned instrument. An access port portion of the trajectory guide can be left in place, without disturbing trajectory alignment, and can allow overlying skin to be sutured closed. The access port can provide infusate delivery, such as using an injection port, catheter or the like. A fiducial marker arrangement can provide easy and accurate trajectory alignment, for use with the present trajectory guide, another trajectory guide, or without any trajectory guide.

Abstract: A trajectory guide for introducing an instrument into a human or animal subject is described. A guide stem can be removed in sections without disturbing the aligned instrument. An access port portion of the trajectory guide can be left in place, without disturbing trajectory alignment, and can allow overlying skin to be sutured closed. The access port can provide infusate delivery, such as using an injection port, catheter or the like. A fiducial marker arrangement can provide easy and accurate trajectory alignment, for use with the present trajectory guide, another trajectory guide, or without any trajectory guide.

Abstract: A trajectory guide for introducing an instrument into a human or animal subject is described. A guide stem can be removed in sections without disturbing the aligned instrument. An access port portion of the trajectory guide can be left in place, without disturbing trajectory alignment, and can allow overlying skin to be sutured closed. The access port can provide infusate delivery, such as using an injection port, catheter or the like. A fiducial marker arrangement can provide easy and accurate trajectory alignment, for use with the present trajectory guide, another trajectory guide, or without any trajectory guide.

Abstract: A first catheter can include a first catheter body providing a longitudinal bore and can have flexible first seal at its distal portion. The first seal can at least partially occlude the bore at the distal portion of the catheter body in a first configuration. A second catheter can be slid into or through the bore of the first catheter body, such as to expand the first seal into a second configuration. Wicking or reflux can be inhibited. Other features, applications, and methods can be included.