Abstract: In certain embodiments a dental strip for the prevention or reduction of dental caries is provided. In certain embodiments the dental strip is constructed to deliver effective amounts of specifically targeted antimicrobial peptides (or simple antimicrobial peptides) and comprises an orally compatible backing layer, a delivery layer disposed on one surface of the backing layer where the delivery layer comprises an orally compatible polymer, or combination of polymers, and a specifically targeted antimicrobial peptide (and/or simple antimicrobial peptide) capable of binding and killing Streptococcus mutans. In certain embodiments the dental strip additionally comprises a release liner.
Type:
Grant
Filed:
April 12, 2018
Date of Patent:
July 25, 2023
Assignee:
C3 Jian, LLC
Inventors:
Evan Schauer, Miroslav Baudys, Brian C. Varnum, Duane Morris, Christopher W. Kaplan, Randal H. Eckert
Abstract: In various embodiments a dental varnish system having improved peptide release and fluoride release properties is provided. In various embodiments a dental varnish system that provides release of an antimicrobial peptide, or specifically targeted antimicrobial peptide (STAMP), e.g., the peptide C16G2, is provided, with or without a fluoride. In various embodiments, a dental varnish system that provides release of a fluoride, with or without an antimicrobial peptide or STAMP is provided. In certain embodiments the dental varnish system comprises a first component that is a dry powder, said first component comprising a an antimicrobial peptide, with or without a fluoride, and a bulking agent, and a second component that is a fluid, said second component comprising a varnish solution, where combination of said first component with said second component provides a varnish formulation for application to the surface of a tooth.
Type:
Grant
Filed:
April 12, 2018
Date of Patent:
April 25, 2023
Assignee:
C3 Jian, LLC
Inventors:
Evan Schauer, Miroslav Baudys, Brian C. Varnum, Christopher W. Kaplan, Randal H. Eckert, Jay Turetzky, Angela Soriaga
Abstract: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.
Type:
Grant
Filed:
May 24, 2016
Date of Patent:
October 30, 2018
Assignees:
The Regents of the University of California, C3 Jian, LLC
Inventors:
Randal H. Eckert, Daniel K. Yarbrough, Wenyuan Shi, Maxwell H. Anderson, Fengxia Qi, Jian He, Ian H. McHardy
Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
Type:
Grant
Filed:
April 17, 2014
Date of Patent:
March 21, 2017
Assignee:
C3 JIAN, LLC
Inventors:
Randal H. Eckert, Chris Kaplan, Jian He, Daniel K. Yarbrough, Maxwell Anderson, Jee-Hyun Sim