Patents Assigned to Cadila Healthcare Limited
  • FORMULATION FOR GONADOTROPINS
    Publication number: 20160250295
    Abstract: The present invention relates to a stable composition for gonadotropins. It provides a composition useful for stabilization of gonadotropins while preventing aggregation, dissociation, fragmentation and formation of oxidized species variants in solution for injection. Thus, it prevents instability of protein or polypeptide molecules caused due to aggregation or fragmentation or oxidation during or after formulation. Also, it provides a pharmaceutical composition of gonadotropins, which can be therapeutically used for the treatment of various indications either in single-dose form or in multi-dose form.
    Type: Application
    Filed: October 31, 2014
    Publication date: September 1, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Chintan PATEL, Mukesh MAHAJAN, Sanjay BANDYOPADHYAY, Sanjee Kumar MENDIRATTA, Bhatt CHANDRESH
  • SUSTAINED-RELEASE COMPOSITIONS COMPRISING TOPIRAMATE AND AN ALKALIZER
    Publication number: 20160235776
    Abstract: The present invention relates to a sustained release composition comprising topiramate and one or more pharmaceutical excipients, wherein the composition comprises a single population of beads, wherein each bead comprises: a) an inert core, b) an inner layer comprising topiramate, c) an outer layer comprising at least one sustained release material and at least one alkalizer. It also relates to methods of preparing such compositions and using those compositions in the treatment of neurological and/or psychiatric condition.
    Type: Application
    Filed: February 9, 2016
    Publication date: August 18, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Sushrut Krishnaji KULKARNI, Ajaykumar HANDA, Amit Om Prakash GUPTA
  • Process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclo hexylmethanisoindol-1,3-dione and its intermediates
    Patent number: 9409899
    Abstract: The present invention discloses process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclohexylmethanisoindol-1,3-dione and intermediates thereof.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: August 9, 2016
    Assignee: Cadila Healthcare Limited
    Inventors: Shri Prakash Dhar Dwivedi, Ramesh Chandra Singh, Rajendra Gokalbhai Chavda
  • Process for the preparation of sitagliptin phosphate
    Patent number: 9409912
    Abstract: The present invention relates to a method for the preparation of sitagliptin phosphate and sitagliptin phosphate anhydrous of Formula (I?) and monohydrate of Formula (I),
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: August 9, 2016
    Assignee: CADILA HEALTHCARE LIMITED
    Inventors: Shri prakash Dhar Dwivedi, Kumar Kamlesh Singh, Sunil Dnyaneshwar Narode, Dhaval Jashvantbhai Patel, Kirtipalsinh Sajjansinh Solanki
  • POLYMORPHIC FORM OF PYRROLE DERIVATIVE AND INTERMEDIATE THEREOF
    Publication number: 20160207884
    Abstract: The present invention relates to Saroglitazar free acid of Formula (IA) or its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable esters, stereoisomers, tautomers, analogs and derivatives thereof. The present invention also provides an amorphous form of saroglitazar free acid and processes of preparation thereof. The present invention also provides pharmaceutical composition comprising an amorphous form saroglitazar magnesium.
    Type: Application
    Filed: August 28, 2014
    Publication date: July 21, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Shri Prakash Dhar DWIVEDI, Ramesh Chandra SINGH, Vikas PATEL, Amar Rajendra DESAI
  • Quinolone derivatives
    Patent number: 9394300
    Abstract: The present invention relates to novel compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: July 19, 2016
    Assignee: Cadila Healthcare Limited
    Inventors: Ranjit C. Desai, Vrajesh Pandya, Pankaj Ramanbhai Patel
  • Purification process for lipopeptides
    Patent number: 9394340
    Abstract: The present invention provides simple, cost effective, rapid, and scalable at industrial scale and provide high purity and yield of Echinocandin-type compounds at low cost as compared to prior art. Moreover the process allows for the removal of impurities by using economical salt-adsorbent complex and provide highly purified Echinocandin type compounds which is highly improved in terms of purity and sufficient for further processing to obtain an active pharmaceutical ingredient such as, the antifungals caspogungin, anidulafungin, and micafungin.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: July 19, 2016
    Assignee: Cadila Healthcare Limited
    Inventors: Menka Gurnani, Rajkumar Maurya
  • Purification Process for PTH
    Publication number: 20160200792
    Abstract: The present invention relates to improved method for purification of a recombinant parathyroid hormone (rhPTH1-34 or teriparatide), said process for purification of parathyroid hormone comprising following essential steps: (a) Enzymatic cleavage; (b) anion exchange chromatography, followed by other suitable purification steps; wherein step (a) and (b) can be carried out in any order.
    Type: Application
    Filed: August 21, 2014
    Publication date: July 14, 2016
    Applicant: Cadila Healthcare Limited
    Inventors: Sanjeev Kumar Mendiratta, Sanjay Bandyopadhyay, Avanish Kumar Singh
  • IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES
    Publication number: 20160194280
    Abstract: The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In particular, the invention relates to an improved process for the preparation of 2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also relates to an improved process for the preparation of mesylate compound (A1).
    Type: Application
    Filed: September 5, 2014
    Publication date: July 7, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Shri Prakash Dhar DWIVEDI, Ramesh Chandra SINGH, Jagdish Maganlal PATEL, Vikas PATEL, Vishwadeepak Rama Pati TRIPATHI, Pranav Jitendra GANGWAR, Jigar Mukundbhai RAVAL
  • Polymorphic forms of ivabradine hydrochloride
    Patent number: 9382209
    Abstract: Stable crystalline Form II and stable crystalline Form III of ivabradine hydrochloride and processes for their preparation are disclosed.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: July 5, 2016
    Assignee: Cadila Healthcare Limited
    Inventors: Shriprakash Dhar Dwivedi, Ashok Prasad, Mukul Hariprasad Sharma, Piyush Rajendra Sharma, Jayprakash Ajitsingh Parihar
  • N-CYANOMETHYLAMIDES AS INHIBITORS OF JANUS KINASE
    Publication number: 20160176849
    Abstract: The present invention relates to compounds of general formula (1) that are inhibitors of Janus Kinase (JAK), a family of tyrosine kinases that are involved in inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. In particular, the compound of the invention inhibits JAK1 and/or JAK2 and/or JAK3 sub families.
    Type: Application
    Filed: August 6, 2014
    Publication date: June 23, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Ranjit DESAI, Jigar DESAI, Pankaj PATEL
  • Amorphous form of apremilast
    Patent number: 9351957
    Abstract: The present invention provides an amorphous form of apremilast and process for preparation thereof. The present invention also provides a pharmaceutical composition comprising an amorphous apremilast and one or more of pharmaceutically acceptable carriers, excipients or diluents used for the treatment of active psoriatic arthritis.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: May 31, 2016
    Assignee: Cadila Healthcare Limited
    Inventors: Brij Khera, Kumar Kamlesh Singh, Santosh Devidas Diwakar, Chetan Jayantibhai Vasava, Anil Kumar Shivprasad Tiwari
  • STABLE PHARMACEUTICAL COMPOSITIONS OF THYROID HORMONE DRUG
    Publication number: 20160143855
    Abstract: The present invention relates to pharmaceutical compositions comprising a thyroid hormone drug. The invention also relates to processes for the preparation of such compositions.
    Type: Application
    Filed: November 20, 2015
    Publication date: May 26, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Muthaiyyan Essakimuthu KANNAN, Nitesh Nalinchandra PANDYA, Chetan Kacharabhai PATEL
  • FORMULA COMPRISING A HYPOLIPIDEMIC AGENT
    Publication number: 20160136131
    Abstract: The present invention relates to the stable pharmaceutical composition of a suitable hypolipidemic agent. Preferably, the present invention discloses novel formulations of the compound of formula (I), or pharmaceutically acceptable salts of compounds of formula (I). More particularly the present invention relates to the stable pharmaceutical composition of compounds of formula (I) comprising compounds of formula (I) or its pharmaceutically acceptable salts, wherein the pH of the formulation is maintained above 7.
    Type: Application
    Filed: July 24, 2014
    Publication date: May 19, 2016
    Applicant: Cadila Healthcare Limited
    Inventors: Jitendre D. Patel, Prakash Davadra, Snehal Patel, Shafiq Sheikh
  • A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES
    Publication number: 20160107989
    Abstract: The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.
    Type: Application
    Filed: May 30, 2014
    Publication date: April 21, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Shriprakash Dhar DWIVEDI, Ramesh Chandra SINGH, Rajendra Gokalbhai CHAVDA, Jagdish Maganlal PATEL, Daya Ram PAL, Jigar Mukundhai RAVAL, Mukul Hariprasad SHARMA, Pranav Jitendra GANGWAR, Sachin Ashokrao PATIL, Vikas PATEL, Vishwadeepak Rama Patil TRIPATHI
  • Combined measles-malaria vaccine
    Patent number: 9308250
    Abstract: A combined measles-malaria vaccine containing different attenuated recombinant measles-malaria vectors comprising a heterologous nucleic acid encoding several Plasmodium falciparum antigens is described. Preferably, it relates to viral vectors that comprise nucleic acids encoding the circumsporozoite (CS) protein of P. falciparum, the merozoite surface protein 1 (MSP-1) of P. falciparum, and its derivatives (p-42; p-83-30-38) in its glycosylated and secreted forms, and apical membrane antigen1 (AMA1) of P. falciparum, in its anchored or secreted form. The viral vector stems from an attenuated measles virus, based on a strain that is used as a vaccine and is efficient in delivering the gene of interest and that binds to and infects the relevant immune cells efficiently.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: April 12, 2016
    Assignee: Cadila Healthcare Limited
    Inventors: Reinhard Glueck, Agata Fazio, Viviana Gianino, Martin A. Billeter
  • POLYMORPHIC FORMS OF LOMITAPIDE AND ITS SALTS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20160083345
    Abstract: The present invention relates to various polymorphic forms of lomitapide or its salts and processes for preparation thereof. The present invention provides Lomitapide mesylate in solid amorphous form and process for preparation thereof. The invention also provides an amorphous solid dispersion of lomitapide mesylate. Further, various crystalline forms of lomitapide mesylate like A, B and C and process for preparation thereof are provided. The invention also provides crystalline forms of lomitapide free base, in particular Form I and Form-II and their preparation. The invention further provides compositions comprising various forms of lomitapide and its salts.
    Type: Application
    Filed: September 18, 2015
    Publication date: March 24, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Sanjay Jagdish DESAI, Brij KHERA, Jagdish Maganlal PATEL, Harshita Bharatkumar SHAH, Arunkumar Shyam Narayan UPADHYAY, Sureshkumar Narbheram AGRAVAT
  • SYNERGISTIC COMPOSITIONS
    Publication number: 20160068484
    Abstract: The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I): processes for the preparation of these novel salts and use thereof.
    Type: Application
    Filed: July 4, 2014
    Publication date: March 10, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Mukul R. JAIN, Suresh GIRI, Himanshu M. KOTHARI, Kaushik BANERJEE, Rashmikant KACHHIYA
  • PHARMACEUTICAL COMPOSITIONS OF TERIFLUNOMIDE
    Publication number: 20160058730
    Abstract: The present invention relates to stable pharmaceutical compositions of teriflunomide or a pharmaceutically acceptable salt thereof. In particular, the invention relates to the stable pharmaceutical compositions of teriflunomide or a pharmaceutically acceptable salt thereof with colloidal silicon dioxide. The invention also relates to processes for the preparation of such compositions and use thereof for treatment of relapsing forms of multiple sclerosis.
    Type: Application
    Filed: August 27, 2015
    Publication date: March 3, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: HANDA AJAY KUMAR, GUPTA AMIT OMPRAKASH, SONI CHIRAG DEEPAKKUMAR
  • Compounds for the treatment of dyslipidemia and related diseases
    Patent number: 9273041
    Abstract: The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. The present invention is directed to compounds suitable for the treatment of Disease conditions such as hyperlipidemia.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: March 1, 2016
    Assignee: Cadila Healthcare Limited
    Inventors: Harikishore Pingali, Pankaj Makadia, Vrajesh Pandya, Sairam V. V. M. Kalapatapu