Abstract: Systems and methods to determine an indication of patient compliance to a prescribed treatment are disclosed, including receive temperature information from a first temperature sensor in a housing of a self-contained monitoring device and from a second temperature sensor located outside of the housing of the self-contained monitoring device, receiving an indication of a prescribed treatment, and determining an indication of patient compliance to the prescribed treatment using the received temperature information occurring over a first period.

Abstract: Systems and methods to determine an indication of patient compliance or patient condition using received physical activity or temperature information are disclosed, including detecting physical activity of the patient, determining indications of patient compliance and patient condition using the detected physical activity, and providing the determined indications of patient compliance and patient condition to a user or process.