Patents Assigned to Calbiochem
  • Differential assay of creatine phosphokinase isoenzymes
    Patent number: 3994783
    Abstract: A process for the determination of creatine phosphokinase MB-isoenzyme (CPK-MB) level in serum in which CPK is determined before and after MB-activation with 1,4-dimercapto-2,3-dihydroxy butane or 2-mercaptoethanol, preferably in an assay system using the ATP/ADP conversion. The difference in the two values found is due to the CPK-MB present. The invention is of particular utility in the diagnosis and treatment of myocardial damage.
    Type: Grant
    Filed: September 26, 1975
    Date of Patent: November 30, 1976
    Assignee: Calbiochem
    Inventors: Parinam Srinivasa Rao, James J. Lukes, Hiltrud S. Mueller