Patents Assigned to Calbiochem-Behring Corp.
  • Reagent system and method for assaying peptidase enzymes
    Patent number: 4260681
    Abstract: A reagent system for assaying a biological specimen for a peptidase enzyme comprising a peptide substrate in which the C-terminal amino acid is dehydroalanine, the enzyme lactate dehydrogenase, the reduced coenzyme nicotinamide adenine dinucleotide and a buffer material.
    Type: Grant
    Filed: December 28, 1978
    Date of Patent: April 7, 1981
    Assignee: Calbiochem-Behring Corp.
    Inventor: John K. Pollard, Jr.
  • Method for terminating a peroxidase catalyzed reaction
    Patent number: 4234680
    Abstract: Addition of a low concentration of an alkali metal metabisulfite completely stops color development in a peroxidase-labeled immunoassay wherein the peroxidase catalyzed reaction comprises oxidation of an achromatic substrate to the corresponding chromatic product in the presence of a peroxide.
    Type: Grant
    Filed: August 3, 1979
    Date of Patent: November 18, 1980
    Assignee: Calbiochem-Behring Corp.
    Inventors: Richard C. Hevey, Mark K. Malmros, Wayne W. Petko
  • Methods for the detection and determination of ligands
    Patent number: 4228237
    Abstract: A method for determining the presence of a ligand in a liquid medium which utilizes enzyme labeled avidin and biotin labeled reagent in a specific binding process wherein the ligand to be detected is contacted with an insoluble phase containing specific binding substance for the ligand. Various protocols may be used to assay the resulting enzyme activity which is related to the amount of ligand in the liquid medium.
    Type: Grant
    Filed: September 21, 1978
    Date of Patent: October 14, 1980
    Assignee: Calbiochem-Behring Corp.
    Inventors: Richard C. Hevey, Mark K. Malmros
  • 3-Hydroxy-3-methylglutaric acid monoamide and derivatives thereof
    Patent number: 4208204
    Abstract: Disclosed as novel compounds are 3-hydroxy-3-methylglutaric acid monoamide and the lower alkyl esters and salts thereof, 3-hydroxy-3-methylglutaramide mononitrile and 3-hydroxy-3-methylglutaramide. 3-Hydroxy-3-methylglutaric acid monoamide and derivatives thereof exhibit anti-germination and anti-growth utility against a wide variety of perennial and annual weed grasses. 3-Hydroxy-3-methylglutaramide mononitrile and 3-hydroxy-3-methylglutaramide have utility as intermediates in the preparation of 3-hydroxy-3-methylglutaric acid monoamide.
    Type: Grant
    Filed: October 7, 1977
    Date of Patent: June 17, 1980
    Assignee: Calbiochem-Behring Corp.
    Inventor: Andre H. Yavrouian
  • Topical treatment of skin diseases
    Patent number: 4133893
    Abstract: A topical preparation for the treatment of skin diseases such as acne vulgaris, acne rosacea, psoriasis and herpes simplex which comprises 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane and a pharmaceutically acceptable carrier or diluent.
    Type: Grant
    Filed: May 26, 1977
    Date of Patent: January 9, 1979
    Assignee: Calbiochem Behring Corp.
    Inventor: Arthur S. Spangler, deceased
  • Process of mitigating cholelithiasis
    Patent number: 4105794
    Abstract: Therapeutic composition useful for mitigating cholelithiasis in humans comprising 3-hydroxy-3-methylglutaric acid, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable non-toxic carrier.
    Type: Grant
    Filed: August 4, 1977
    Date of Patent: August 8, 1978
    Assignee: Calbiochem-Behring Corp.
    Inventors: William Drell, John K. Pollard, Jr.