Patents Assigned to Calcitec, Inc.
  • Process for affecting the setting and working time of bioresorbable calcium phosphate cements
    Patent number: 7279038
    Abstract: A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5-2.5. The wetting solution suitable for use in the process of the present invention includes water, an organic solvent, an acidic and basic solution. A setting solution for mixing with the heated powder to form the fast-setting, bioresorbable calcium phosphate cement may be water, an acidic or basic solution according to the process of the present invention.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: October 9, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Process for affecting the setting and working time of bioresorbable calcium phosphate cements
    Patent number: 7258735
    Abstract: A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5-2.5. The wetting solution suitable for use in the process of the present invention includes water, an organic solvent, an acidic and basic solution. A setting solution for mixing with the heated powder to form the fast-setting, bioresorbable calcium phosphate cement may be water, an acidic or basic solution according to the process of the present invention.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: August 21, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Kuan-Liang Lin, I-Chang Wang
  • Injectable calcium phosphate cements and the preparation and use thereof
    Patent number: 7258734
    Abstract: A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: August 21, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Injectable calcium phosphate cements and the preparation and use thereof
    Patent number: 7214265
    Abstract: A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: May 8, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
    Patent number: 7204876
    Abstract: A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers on a surface thereof; the basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm. The basic calcium phosphate whiskers are substantially free of a hydroxyapatite phase and mainly composed of TTCP phase.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: April 17, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Process for affecting the setting and working time of, bioresorbable calcium phosphate cements
    Patent number: 7201797
    Abstract: A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5–2.5. The wetting solution suitable for use in the process of the present invention includes water, an organic solvent, an acidic and basic solution. A setting solution for mixing with the heated powder to form the fast-setting, bioresorbable calcium phosphate cement may be water, an acidic or basic solution according to the process of the present invention.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: April 10, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Kuan-Liang Lin, I-Chang Wang
  • Process for affecting the setting and working time of bioresorbable calcium phosphate cements
    Patent number: 7186294
    Abstract: A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5–2.5. The wetting solution suitable for use in the process of the present invention includes water, an organic solvent, an acidic and basic solution. A setting solution for mixing with the heated powder to form the fast-setting, bioresorbable calcium phosphate cement may be water, an acidic or basic solution according to the process of the present invention.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: March 6, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Dual function prosthetic bone implant and method for preparing the same
    Patent number: 7182895
    Abstract: The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: February 27, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Chih-Hung Tsai
  • Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
    Patent number: 7182928
    Abstract: A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers on a surface thereof; the basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm. The basic calcium phosphate whiskers are substantially free of a hydroxyapatite phase and mainly composed of TTCP phase.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: February 27, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
    Patent number: 7169373
    Abstract: A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers on a surface thereof; the basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm. The basic calcium phosphate whiskers are substantially free of a hydroxyapatite phase and mainly composed of TTCP phase.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: January 30, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen, Kuan-Liang Lin, I-Chang Wang
  • Method for making a porous calcium phosphate article
    Patent number: 7163651
    Abstract: The present invention discloses a method for making a porous calcium phosphate article including i) preparing a shaped article from a paste containing a calcium phosphate cement, a pore-forming powder and a setting liquid; ii) immersing the shaped article in an immersing liquid for a period of time so that the pore-forming powder is dissolved in the immersing liquid, creating pores in said shaped article; and iii) removing the resulting porous shaped article from the immersing liquid, wherein the resulting porous shaped article has an improved compressive strength. The porous shaped calcium phosphate article of the present invention may be used as a tissue-engineered scaffold, medical implant or a reinforcing constituent of a composite.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: January 16, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Yin-Chun Tien, Chih-Hung Tsai, Chao-Chin Ning, Chung-Po Chao
  • Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
    Patent number: 7160381
    Abstract: A tetracalcium phosphate (TTC P) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers or fine crystals on a surface thereof; the basic calcium phosphate whiskers or fine crystals having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: January 9, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
    Patent number: 7160382
    Abstract: A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers on a surface thereof; the basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm. The basic calcium phosphate whiskers are substantially free of a hydroxyapatite phase and mainly composed of TTCP phase.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: January 9, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
    Patent number: 7156915
    Abstract: A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers or fine crystals on a surface thereof; the basic calcium phosphate whiskers of fine crystals having a Ca/P molar greater that 1.33, and having a length up to about 5000 nm and a width up to about 500 nm.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: January 2, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
  • Dual function prosthetic bone implant and method for preparing the same
    Patent number: 7157027
    Abstract: The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: January 2, 2007
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Chih-Hung Tsai
  • Dual function prosthetic bone implant and method for preparing the same
    Patent number: 7128856
    Abstract: The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: October 31, 2006
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Chih-Hung Tsai
  • Dual function prosthetic bone implant and method for preparing the same
    Patent number: 7122139
    Abstract: The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: October 17, 2006
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Chih-Hung Tsai
  • Dual function prosthetic bone implant and method for preparing the same
    Patent number: 7122140
    Abstract: The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: October 17, 2006
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Chih-Hung Tsai
  • Dual function prosthetic bone implant and method for preparing the same
    Patent number: 7122138
    Abstract: The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: October 17, 2006
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Chih-Hung Tsai
  • Dual function prosthetic bone implant and method for preparing the same
    Patent number: 7118695
    Abstract: The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: October 10, 2006
    Assignee: Calcitec, Inc.
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju, Chih-Hung Tsai