Patents Assigned to California
  • Publication number: 20190280725
    Abstract: A crystal-free radio includes an antenna; a receiver configured to communicate with the antenna; a local radio frequency (RF) oscillator configured to communicate with the receiver; and a clock circuit configured to communicate with the receiver and the local RF oscillator, the clock circuit having an electronic circuit oscillator. The local RF oscillator is a free-running oscillator. The clock circuit is configured to receive a calibration signal via a wireless network and calibrate the electronic circuit oscillator based on the received calibration signal, and the clock circuit is a crystal-free clock circuit.
    Type: Application
    Filed: May 8, 2017
    Publication date: September 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Kristofer S.J. PISTER, Osama Ullah KHAN, Bradley WHEELER, David C. BURNETT
  • Publication number: 20190279369
    Abstract: Object and shape detection in digital images utilizing edge detection is described. In a first edge detection approach, phase transformation is utilized in the frequency domain, such as in response to Fourier transform, followed by use of a frequency-domain phase kernel and inverse-Fourier transform. Edge detection is also provided using a phase transform in the spatial domain utilizing a convolution approach. In a second edge detection approach, phase stretching is utilized, such as in combination with phase histogramming along with thresholding and morphological operations. Numerous example images are provided illustrating benefits of the disclosed technology with different applications and under different conditions.
    Type: Application
    Filed: March 19, 2019
    Publication date: September 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Bahram Jalali, Mohammadhossein Asghari
  • Publication number: 20190279424
    Abstract: A method, apparatus, and system provide the ability to control navigation of a three-dimensional (3D) computer aided design (CAD) model in an augmented reality space. The 3D CAD model is rendered in the augmented reality space and appears as if it is present in a physical space at true scale. A virtual camera is defined as fixed to a current pose of a user's head. A virtual line segment S is constructed coincident with a ray R from a center of projection P of the virtual camera and a center pixel of the virtual camera. A check for geometric intersections between the virtual line segment S and surfaces of scene elements is conducted. Upon intersecting with a part of the model, a gaze cursor is rendered at an intersection point C closest to the center of projection P.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 12, 2019
    Applicant: California Institute of Technology
    Inventors: Matthew C. Clausen, Charles Goddard, Garrett K. Johnson, Marsette A. Vona, III, Victor X. Luo, Jeffrey S. Norris, Anthony J. Valderrama
  • Publication number: 20190274584
    Abstract: A selective-sorting system for aerosol droplets in human breath includes a mouthpiece to receive a flow of human breath, and a flow path coupled to the mouthpiece. This flow path includes one or more bends that cause the flow of human breath to change direction, which causes aerosol droplets in the flow having different mass-sizes to change direction at different rates. Moreover, the flow path is shaped so that droplets that change direction at different rates are directed to different destinations. The system also includes a collection path, which is coupled to the flow path so that aerosol droplets meeting a specific mass-size criterion are directed into the collection path. A condenser tube is located in the collection path, wherein the condenser tube includes a cooling mechanism that cools the condenser tube to facilitate condensing aerosol droplets to sides of the condenser tube for subsequent collection.
    Type: Application
    Filed: November 22, 2017
    Publication date: September 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Cristina E. Davis, Konstantin O. Zamuruyev, Michael Schivo, Nicholas J. Kenyon, Jean-Pierre Delplanque, Alexander A. Aksenov
  • Publication number: 20190274698
    Abstract: Provided herein are devices related to the removal of uroliths, including kidney, ureteral and/or bladder stones. In one embodiment, the device comprises a mesh or sponge that is removably connected to a catheter, adapted for the removal of urolith fragments of the size 2 mm or less. In one embodiment, the device includes a catheter that is either solid or hollow, the latter for the irrigation of various types of fluid (either standard irrigation fluid (e.g. saline or water) or a material (e.g. blood, fibrin glue, etc.) that would form a clot like substance within the interstices of the device thereby increasing its ability to entrap fragments within the interstices of the basket or nearby.
    Type: Application
    Filed: January 21, 2019
    Publication date: September 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Kamaijot Kaler, Daniel Meller, Roshan M. Patel, Ralph V. Clayman
  • Publication number: 20190276537
    Abstract: Segregation modulation therapeutics comprise a recombinant macromolecule comprising an effector-binding module and an anchor-binding module joined by a linker, wherein the modules are specific for an effector and an anchor, respectively of a target cell, and bound thereto, the enforces an effector-anchor complex such that the effector and anchor molecules are spatially co-localized on the target cell.
    Type: Application
    Filed: May 17, 2019
    Publication date: September 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Daniel A. Fletcher, Matthew H. Bakalar, Eva M. Schmid
  • Publication number: 20190276805
    Abstract: Methods for catalyzing C—H insertion reactions using heme enzymes are described. The present disclosure provides a method for producing a C—H insertion product comprising providing an substrate having an sp3-hybridized C—H bond, a carbene precursor such as a diazo reagent, and a heme enzyme, and admixing the components in a reaction for a time sufficient to produce the C—H insertion product. Heme enzyme variants useful for carrying out in vivo and in vitro C—H insertion reactions, as well as expression vectors and host cells expressing the heme enzymes, are also described.
    Type: Application
    Filed: January 24, 2019
    Publication date: September 12, 2019
    Applicant: California Institute of Technology
    Inventors: Ruijie Zhang, Lena Wohlschlager, Hans H. Renata, Frances H. Arnold, Kai Chen
  • Publication number: 20190274932
    Abstract: Conventional dental cements lack certain properties such as the facilitation of optimal re-mineralization. The novel bioactive glass-ionomer dental and bone cement formulations disclosed herein induces mineralization at the in vivo interface and exhibits superior handling properties (shorter setting time) and mechanical properties (improved bond strength to dentin and flexural strength). The present invention presents the first bioactive glass-ionomer dental cement with mineralization power, exhibiting improved bond strength to tooth structure, sharp setting time and superior mechanical strength. Materials of this invention can be used as bone cement, as a dental filling (restorative material), as a liner for deep cavity preparations (to avoid root canal therapies and tooth sensitivity), or as a luting cement to cement dental crowns. Moreover, it can be utilized in a flowable resin for use as a coating to prevent dental caries in their initial steps (white spots).
    Type: Application
    Filed: January 24, 2019
    Publication date: September 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Alireza MOSHAVERINIA, Mohammad Mahdi HASANI-SADRABADI, Tara L. AGHALOO
  • Publication number: 20190276787
    Abstract: The present invention relates to biomimetic membrane compositions and methods for making and using them.
    Type: Application
    Filed: January 31, 2019
    Publication date: September 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Alireza MOSHAVERINIA, Mohammad Mahdi HASANI-SADRABADI, Paul S. Weiss, Tara L. Aghaloo
  • Patent number: 10406169
    Abstract: Provided are methods for treating a neurodegenerative disease, such as multiple sclerosis, in a subject receiving a first estriol treatment regimen, comprising obtaining a measurement of the serum estriol concentration in the blood of the subject, and administering a second estriol treatment regimen to the subject if the serum estriol concentration is less than 6 ng/mL. The daily amount of estriol administered during the second estriol treatment regimen is preferably greater than the daily amount of estriol administered during the first estriol treatment regimen.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: September 10, 2019
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Patent number: 10406389
    Abstract: Fire block devices for application to a wall component. The fire-block device can be a wall component that includes a fire-resistant material strip that expands in response to sufficient heat to create a fire-resistant barrier. In some applications, the fire-block wall component is positioned to extend lengthwise along and across a gap between wallboard members. The fire-block wall component may have a U-shaped central portion and a pair of side portions extending in opposite directions from the central portion. The fire-resistant material may be positioned on the central portion of the fire-block device. The central portion may be positioned within the gap such that the fire-resistant material expands in response to sufficient heat to create a fire-resistant barrier.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: September 10, 2019
    Assignee: California Expanded Metal Products Company
    Inventors: Donald Anthony Pilz, Raymond Edward Poliquin
  • Patent number: 10406211
    Abstract: Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: September 10, 2019
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Dianne K. Newman, Ryan C. Hunter, George A O'Toole
  • Patent number: 10407374
    Abstract: The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, IL-6, IL-6-R, NADPH oxidase (Nox), and/or superoxide and/or hydrogen peroxide production by a NADPH oxidase, including for example ameliorating, treating, reversing or preventing schizophrenia, psychosis, delirium, e.g., post-operative delirium, drug-induced psychosis, psychotic features associated with frailty syndrome (FS), aging, depression, dementias; traumatic war neurosis, post traumatic stress disorder (PTSD) or post-traumatic stress syndrome (PTSS), Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), and/or Multiple Sclerosis (MS). The invention also provides methods for purifying a C60 fullerene, C3 (tris malonic acid C60) or malonic acid derivatives.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: September 10, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Laura L. Dugan, Marie Margarita Behrens, Sameh Ali
  • Patent number: 10411811
    Abstract: A system includes a transmitter with multiple transmit devices each having an OAM multiplexer that converts multiple input signals into an OAM beam. Each transmit device outputs a coaxial group of orthogonal OAM beams. The system also includes a receiver that has multiple receive devices each having an OAM demultiplexer that receives the group of OAM beams from a corresponding transmit device. The OAM demultiplexer also converts the coaxial group of mutually orthogonal OAM beams into a plurality of received signals corresponding to input signals represented by the OAM beams. The receiver also includes a MIMO processor that has an equalizer that determines a transfer function corresponding to crosstalk of each of the plurality of received signals. The MIMO processor also reduces the crosstalk of each of the plurality of received signals based on the transfer function and updates the transfer function.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: September 10, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Alan E. Willner, Yongxiong Ren, Long Li, Guodong Xie, Yinwen Cao, Zhe Wang, Cong Liu, Asher J. Willner
  • Patent number: 10406602
    Abstract: The disclosure provides methods to produce ultrathin metal nanowires, the metal nanowires produced therefrom, and the use of the metal nanowires as transparent conductors.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: September 10, 2019
    Assignee: The Regents of the University of California
    Inventors: Peidong Yang, Jianwei Sun, Yi Yu, Fan Cui
  • Patent number: 10406227
    Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 10, 2019
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Robert H. Chow, Mark S. Humayun, Harry B. Gray, Robert H. Grubbs, Dennis A. Dougherty, Mark E. Thompson, Lionel E. Cheruzel, Melanie A. Yen
  • Patent number: 10407488
    Abstract: The present application generally relates to methods to prevent or treat bleeding and/or hypocoagulation in an individual in need thereof, and compositions for use in such methods. The methods comprise administration of FVa, preferably an APC resistant FVa (such as superFVa), alone or in combination with FVIIa, preferably rhFVIIa (such as NovoSeven® or another FVIIa having enhanced activity or half-life). When administered in combination, FVa and FVIIa elicit a synergistic benefit when used to treat or prevent bleeding or hypocoagulation in subjects in need thereof, e.g.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: September 10, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: John H. Griffin, Laurent Mosnier, Annette Von Drygalski, Andrew Gale
  • Patent number: 10406225
    Abstract: Antibodies that bind to tumor associated antigen CD44 or to tumor associated antigen EphA2, are disclosed herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies, diagnostics, and screening methods.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: September 10, 2019
    Assignee: The Regents of the University of California
    Inventors: Yu Zhou, James D. Marks
  • Patent number: 10406233
    Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: September 10, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Juntao Luo, Kit Lam
  • Patent number: 10407697
    Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 10, 2019
    Assignees: The Regents of the University of California, University of Vienna
    Inventors: Jennifer A. Doudna, Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier