Abstract: A magnetic spectrometer is integrated in a semiconductor substrate and provides high sensitivity without using an external magnet field. The spectrometer includes one or more highly stable on-chip oscillator and LC resonator. A current caused to pass through the inductor generates a magnetic field and polarizes the nanoparticles placed in its proximity, thereby changing the effective inductance of the inductor, and in turn, modifying the oscillation frequency of the LC resonator. The shift in the oscillation frequency is used to characterize the nanoparticles and measure their magnetic susceptibility frequency profile. The spectrometer operates at multiple frequencies over a diverse range without using a reference sensor thereby effectively increasing its spatial multiplexing density.
Type:
Grant
Filed:
September 16, 2013
Date of Patent:
May 1, 2018
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Constantine Sideris, Seyed Ali Hajimiri
Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.
Type:
Grant
Filed:
May 22, 2015
Date of Patent:
May 1, 2018
Assignees:
CALIFORNIA INSTITUTE OF TECHNOLOGY, SANOFI
Inventors:
Aditya Rajagopal, Chieh-feng Chang, Oliver Plettenburg, Stefan Petry, Axel Scherer, Charles L. Tschirhart
Abstract: An image sensor includes an optical sensor layer including a plurality of light-sensitive cells configured to sense light to generate electrical signals, and a color filter array layer disposed on the optical sensor layer and including a plurality of color filters respectively facing the plurality of light-sensitive cells. Each of the plurality of color filters includes a nanostructure in which a first material having a first refractive index and a second material having a second refractive index higher than the first refractive index are arranged. The first material and the second material are alternatively positioned at an interval less than a central wavelength of a color of the color filter. Thus, a thin image sensor having good wavelength selectivity and suitable for obtaining high resolution images is provided.
Type:
Grant
Filed:
November 30, 2015
Date of Patent:
May 1, 2018
Assignees:
SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Seunghoon Han, Yu Horie, Andrei Faraon, Sungwoo Hwang
Abstract: Method for preparing molecular sieves and molecular sieves obtained thereby are described. The method includes preparing a reaction mixture, comprising a structure directing agent, at least one source of at least one oxide of a tetravalent element, optionally, one or more sources of one or more oxides selected from the group consisting of oxides of trivalent elements, pentavalent elements, and mixtures thereof, optionally, at least one source of an element selected from Groups 1 and 2 of the Periodic Table; and optionally, hydroxide ions or fluoride ions, and maintaining the reaction mixture under conditions sufficient to form crystals of the molecular sieve. In the method, various imidazolium cations are used as the structure directing element.
Abstract: The present invention is directed to brush block copolymer compositions comprising first and second homopolymers or random copolymers whose presence provides access to photonic bandgaps in the infrared frequency range, their use in this capacity, and methods of making the same. The specific parameters associated with these compositions are described within the specification.
Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
Type:
Grant
Filed:
February 1, 2017
Date of Patent:
May 1, 2018
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
Abstract: Technologies are generally described for systems, devices and methods relating to determining weights in a machine learning environment. In some examples, a training distribution of training data may be identified, information about a test distribution of test data, and a coordinate of the training data and the test data may be identified. Differences between the test distribution and the training distribution may be determined, for the coordinate. A weight importance parameter may be identified, for the coordinate. A processor may calculate weights based on the differences, and based on the weight importance parameter. The weights may be adapted to cause the training distribution to conform to the test distribution at a degree of conformance. The degree of conformance may be based on the weight importance parameter.
Type:
Grant
Filed:
August 5, 2014
Date of Patent:
April 24, 2018
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Yaser Said Abu-Mostafa, Carlos Roberto Gonzalez
Abstract: Electrochemical systems with electronically and ionically conductive layers have electronic, mechanical and chemical properties useful for a variety of applications including electrochemical storage and conversion. Electronically and ionically conductive layers may be introduced between an electrode and the separator. Embodiments provide structural, physical and electrostatic attributes useful for managing and controlling dendrite formation and for improving the cycle life and rate capability of electrochemical cells including silicon anode based batteries, air cathode based batteries, redox flow batteries, solid electrolyte based systems, fuel cells, flow batteries and semisolid batteries and may include multilayer, porous geometries supporting excellent ion transport properties, providing a barrier to prevent dendrite initiated mechanical failure, shorting or thermal runaway, or providing improved electrode conductivity and improved electric field uniformity.
Abstract: Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control. One embodiment includes a node controller including a distributed power control application; a plurality of node operating parameters describing the operating parameter of a node and a set of at least one node selected from the group consisting of an ancestor node and at least one child node; wherein send node operating parameters to nodes in the set of at least one node; receive operating parameters from the nodes in the set of at least one node; calculate a plurality of updated node operating parameters using an iterative process to determine the updated node operating parameters using the node operating parameters that describe the operating parameters of the node and the set of at least one node, where the iterative process involves evaluation of a closed form solution; and adjust node operating parameters.
Abstract: Both rewriting and error correction are technologies usable for non-volatile memories, such as flash memories. A coding scheme is disclosed herein that combines rewriting and error correction for the write-once memory model. In some embodiments, code construction is based on polar codes, and supports any number of rewrites and corrects a substantial number of errors. The code may be analyzed for a binary symmetric channel. The results can be extended to multi-level cells and more general noise models.
Type:
Grant
Filed:
July 5, 2013
Date of Patent:
April 17, 2018
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Anxiao Jiang, Yue Li, Eyal En Gad, Michael Langberg, Jehoshua Bruck
Abstract: Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface attachment features that are spaced apart on the surface such that when the analytes are labeled adjacent analytes are optically resolvable from each other. One way to express this concept is that binding elements should be spaced apart such that the Guassian point spread functions of adjacent labels do not overlap. Another way of expressing this concept is that the surface binding elements should be spaced apart by a distance equal to at least the diffraction limit for an optical label attached to the bound analytes.
Type:
Grant
Filed:
November 27, 2013
Date of Patent:
April 17, 2018
Assignees:
STANFORD UNIVERSITY, UNIVERSITY OF CHICAGO, CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Jerrod Schwartz, Stephen R. Quake, Milan Mrksich
Abstract: A flow control valve for use in oil well bore holes. The flow control valve includes a plurality of flow paths connected in parallel. The flow control valve operates by successively opening different flow paths, starting with a flow path that requires a reduced force to operate its inlet valve. The flow rate through the flow control valve is controlled by opening and closing different ones of the plurality of flow paths individually or in combination. A flow path that allows fluid to flow at substantially the full flow rate of the valve is provided as one of the parallel paths. A simple mechanical design using poppet valves and at least one cam is described.
Type:
Grant
Filed:
February 6, 2014
Date of Patent:
April 17, 2018
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Xiaoqi Bao, Mircea Badescu, Stewart Sherrit, Jeffery L. Hall, Yoseph Bar-Cohen
Abstract: An imaging apparatus and an image sensor including the same are provided. The imaging apparatus includes first, second, and third optical devices. At least one of the first, second, and third optical devices is a thin-lens including nanostructures.
Type:
Grant
Filed:
April 21, 2016
Date of Patent:
April 17, 2018
Assignees:
SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Seunghoon Han, Amir Arbabi, Andrei Faraon, Sungwoo Hwang, Jangwoo You, Byounglyong Choi
Abstract: A method for coupling an alkane with an alkene using a hydrogen transfer catalyst and an alkene dimerization catalyst to form one or more higher molecular weight hydrocarbons.
Type:
Grant
Filed:
May 16, 2017
Date of Patent:
April 17, 2018
Assignee:
California Institute of Technology
Inventors:
David Leitch, Jay A. Labinger, John E. Bercaw, Yan Choi Lam
Abstract: According to some embodiments herein, expression systems and methods for reversible gene expression are provided. In some embodiments, adeno-associated viral vectors encoding a gene product of interest and comprising a plurality of recombinase target sites are provided. In some embodiments, a source of recombinase is provided. In some embodiments, the gene product of interest is expressed, and the recombinase then induces recombination events between the recombinase target sites, thus reducing or eliminating expression of the gene product of interest.
Type:
Grant
Filed:
October 30, 2013
Date of Patent:
April 17, 2018
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Alejandro Benjamin Balazs, David Baltimore
Abstract: An on-chip optical filter having Fabri-Perot resonators and a spectrometer may include a first sub-wavelength grating (SWG) reflecting layer and a second SWG reflecting layer facing each other. A plurality of Fabri-Perot resonators are formed by the first SWG reflecting layer and the second SWG reflecting layer facing each other. Each of the Fabri-Perot resonators may transmit light corresponding to a resonance wavelength of the Fabri-Perot resonator. The resonance wavelengths of the Fabri-Perot resonators may be determined according to duty cycles of grating patterns.
Type:
Grant
Filed:
August 29, 2016
Date of Patent:
April 10, 2018
Assignees:
SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Seunghoon Han, Yu Horie, Andrei Faraon, Amir Arbabi
Abstract: Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. Each radioluminescent light source includes an interior chamber coated with phosphor material, such as zinc sulfide, and containing a radioisotope material, such as gaseous tritium. The volume, shape, phosphor material, and radioisotope material are selected for emission of light at a particular wavelength and delivering a particular irradiance on the retina (when implanted in an eyeball). The wavelength is in the range of 400 to 600 nm and the irradiance is substantially 109 to 1011 photons per second per cm2.
Abstract: Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.
Type:
Grant
Filed:
June 30, 2016
Date of Patent:
April 3, 2018
Assignees:
CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEURORECOVERY TECHNOLOGIES, INC.
Inventors:
Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Yangsheng Chen