Abstract: This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of Alzheimer's Disease in humans. The method comprises administering an effective amount of a triarylmethyl amine compound having the general formula: wherein the R1 group may comprise acyclic amines and aliphatic amines. The R2 group may comprise one of three aryl varieties: aryl, substituted aryl, or heterocycle. Triarylamine compounds inhibit apolipoprotein E expression in mammalian cells. In one aspect of the invention the mammalian cells may be human cells, and more specifically may be human brain cells.

Abstract: This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of Alzheimer's Disease in humans. The method comprises administering an effective amount of a triarylmethyl amine compound having the general formula: wherein the R1 group may comprise acyclic amines and aliphatic amines. The R2 group may comprise one of three aryl varieties: aryl, substituted aryl, or heterocycle. Triarylamine compounds inhibit apolipoprotein E expression in mammalian cells. In one aspect of the invention the mammalian cells may be human cells, and more specifically may be human brain cells.

Abstract: A method and pharmaceutical composition for inhibiting infections of pathogenic microorganisms by inhibiting the production of ADP-glucose, particularly by inhibiting the activity of ADP-glucose pyrophosphorylase or glycogen synthase.

Abstract: Mach's principle and local Lorentz-invariance together yield the prediction of transient rest mass fluctuations in accelerated objects. These restmass fluctuations, in both principle and practice, can be quite large and, in principle at least, negative. They suggest that exotic space time transport devices may be feasible, the least exotic being "impulse engines", devices that can produce accelerations without ejecting any material exhaust. Such "impulse engines" rely on inducing transient mass fluctuations in conventional electrical circuit components and combining them with a mechanically coupled pulsed thrust to produce propulsive forces without the ejection of any propellant. The invention comprises a method of producing propellant-less thrust by using force transducers (piezoelectric devices or their magnetic equivalents) attached to resonant mechanical structures.

Abstract: New sensing and diagnostic methods are implemented with multimode fiber Bragg gratings (MMFBG) and methods for sensor addressing and multiplexing are described. Real time structural strain and vibration monitoring using optical time domain reflectometry (OTDR) is discussed. The first all-mode, wave optics calculations of the reflectivity of Bragg gratings in highly multimode optical fibers are presented, including the effects of individual mode power changes due to microbending transducer loss upstream from the grating. Two categories of multimode fiber gratings are possible, independent mode and mode coupling, and the fabrication differences between these types of gratings are described. The reflectivity properties of independent mode multimode fiber gratings are examined and compared to single mode fiber gratings.

Abstract: A 10 to 18 mm. diameter vial, 50 to 65 mm. in height, of specialized construction requires a grommet or integral flange on both ends to retain the vial in vertical position while counting liquid radioactive material therein on a conveyor system.