Patents Assigned to California Stem Cell, Inc.
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Publication number: 20130344598Abstract: Aspects of implementations wherein reductions in contamination in transplantation cell population are disclosed herein, including incubating a suspended population of live cells in a culture medium with a substrate having surface that promotes cell to cell adhesion. During the process, the incubating is in absence of substantial mechanical disturbance of the culture medium and cells are in the culture medium for a predetermined period of time. A resulting population of cells which is relatively reduced or eliminated in contaminants is taught. Said population of cells may be collectable by centrifugation and is separable from said contaminants by centrifugation.Type: ApplicationFiled: January 24, 2012Publication date: December 26, 2013Applicant: California Stem Cell, Inc.Inventor: Gabriel Nistor
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Patent number: 8569061Abstract: The invention provides media formulations. A complete media formulation of the invention includes, for example, the following components: albumin, an iron carrier, glutamine, a glycosidase or hydrolase, fibroblast growth factor (FGF), a salt or mineral, and essential amino acids at an osmolarity of about 220-330 mOsm/Liter.Type: GrantFiled: June 1, 2011Date of Patent: October 29, 2013Assignee: California Stem Cell, Inc.Inventor: Gabriel Nistor
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Patent number: 8465975Abstract: Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% viable cells, as well as method of making and using the same, including deriving late stage MNP cells from pluripotent embryonic stem cells, producing high-purity populations of late stage MNP cells, producing populations of viable MNP cells, transporting viable MNP cells, and transplanting MNP cells.Type: GrantFiled: December 13, 2011Date of Patent: June 18, 2013Assignee: California Stem Cell, Inc.Inventor: Aleksandra Jovanovic Poole
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Patent number: 8465974Abstract: Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% viable cells, as well as method of making and using the same, including deriving late stage MNP cells from pluripotent embryonic stem cells, producing high-purity populations of late stage MNP cells, producing populations of viable MNP cells, transporting viable MNP cells, and transplanting MNP cells.Type: GrantFiled: September 23, 2011Date of Patent: June 18, 2013Assignee: California Stem Cell, Inc.Inventor: Aleksandra J. Poole
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Patent number: 8450110Abstract: The invention provides neuronal progenitor cells, populations and cultures of cells, cell compositions and methods of producing neuronal progenitor cells. Neuronal progenitor cells can be prepared from embryonic stem cells, such as human embryonic stem cells.Type: GrantFiled: March 20, 2012Date of Patent: May 28, 2013Assignee: California Stem Cell, Inc.Inventor: Aleksandra Jovanovic Poole
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Patent number: 8211698Abstract: The invention provides neuronal progenitor cells, populations and cultures of cells, cell compositions and methods of producing neuronal progenitor cells. Neuronal progenitor cells can be prepared from embryonic stem cells, such as human embryonic stem cells.Type: GrantFiled: August 4, 2008Date of Patent: July 3, 2012Assignee: California Stem Cells, Inc.Inventor: Aleksandra Jovanovic Poole
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Publication number: 20120107934Abstract: Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% viable cells, as well as method of making and using the same, including deriving late stage MNP cells from pluripotent embryonic stem cells, producing high-purity populations of late stage MNP cells, producing populations of viable MNP cells, transporting viable MNP cells, and transplanting MNP cells.Type: ApplicationFiled: December 13, 2011Publication date: May 3, 2012Applicant: CALIFORNIA STEM CELL, INC.Inventor: Aleksandra Poole
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Patent number: 8153427Abstract: The invention provides methods for producing a culture of cardiomyocytes and cultures of cardiomyocytes. Exemplary methods of producing and cultures of cardiomyocytes include a population of cells including cells having spontaneous and periodic electrical activity, and/or including nodal, sino-atrial or pacemaker cells; immature cardiomyocytes (cardiomyoblasts); mature contractile cardiomyocytes; or a mixed population of two or more of such cells.Type: GrantFiled: March 17, 2008Date of Patent: April 10, 2012Assignee: California Stem Cell, Inc.Inventor: Gabriel Nistor
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Patent number: 8137971Abstract: Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% viable cells, as well as method of making and using the same, including deriving late stage MNP cells from pluripotent embryonic stem cells, producing high-purity populations of late stage MNP cells, producing populations of viable MNP cells, transporting viable MNP cells, and transplanting MNP cells.Type: GrantFiled: March 24, 2008Date of Patent: March 20, 2012Assignee: California Stem Cell, Inc.Inventor: Aleksandra J. Poole
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Publication number: 20120014931Abstract: Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% viable cells, as well as method of making and using the same, including deriving late stage MNP cells from pluripotent embryonic stem cells, producing high-purity populations of late stage MNP cells, producing populations of viable MNP cells, transporting viable MNP cells, and transplanting MNP cells.Type: ApplicationFiled: September 23, 2011Publication date: January 19, 2012Applicant: California Stem Cell, Inc.Inventor: Aleksandra J. Poole
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Patent number: 7977096Abstract: The invention provides media formulations. A complete media formulation of the invention includes, for example, the following components: albumin, an iron carrier, glutamine, a glycosidase or hydrolase, fibroblast growth factor (FGF), a salt or mineral, and essential amino acids, at an osmolarity of about 220-330 mOsm/Liter.Type: GrantFiled: January 3, 2008Date of Patent: July 12, 2011Assignee: California Stem Cell, Inc.Inventor: Gabriel Nistor
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Publication number: 20090175834Abstract: The invention provides neuronal progenitor cells, populations and cultures of cells, cell compositions and methods of producing neuronal progenitor cells. Neuronal progenitor cells can be prepared from embryonic stem cells, such as human embryonic stem cells.Type: ApplicationFiled: August 4, 2008Publication date: July 9, 2009Applicant: California Stem Cell, Inc.Inventor: ALEKSANDRA JOVANOVIC POOLE
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Publication number: 20090155831Abstract: The invention provides methods for producing a culture of cardiomyocytes and cultures of cardiomyocytes. Exemplary methods of producing and cultures of cardiomyocytes include a population of cells including cells having spontaneous and periodic electrical activity, and/or including nodal, sino-atrial or pacemaker cells; immature cardiomyocytes (cardiomyoblasts); mature contractile cardiomyocytes; or a mixed population of two or more of such cells.Type: ApplicationFiled: March 17, 2008Publication date: June 18, 2009Applicant: California Stem Cell, Inc.Inventor: GABRIEL NISTOR
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Publication number: 20090035860Abstract: The invention provides media formulations. A complete media formulation of the invention includes, for example, the following components: albumin, an iron carrier, glutamine, a glycosidase or hydrolase, fibroblast growth factor (FGF), a salt or mineral, and essential amino acids, at an osmolarity of about 220-330 mOsm/Liter.Type: ApplicationFiled: January 3, 2008Publication date: February 5, 2009Applicant: CALIFORNIA STEM CELL, INC.Inventor: GABRIEL NISTOR
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Publication number: 20080305086Abstract: Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% viable cells, as well as method of making and using the same, including deriving late stage MNP cells from pluripotent embryonic stem cells, producing high-purity populations of late stage MNP cells, producing populations of viable MNP cells, transporting viable MNP cells, and transplanting MNP cells.Type: ApplicationFiled: March 24, 2008Publication date: December 11, 2008Applicant: California Stem Cell, Inc.Inventor: ALEKSANDRA J. POOLE