Abstract: Systems and methods relating to a smart elastic fabric tape are disclosed. For example, a method may include interrogating a sensing mesh using an electrical impedance tomography (EIT) device, wherein the sensing mesh is affixed onto skin nearby a musculoskeletal (MSK) region of interest, wherein the sensing mesh comprises a nanocomposite thin film disposed on elastic fabric tape, and wherein the sensing mesh forms a geometrical pattern on the skin; generating, in real-time, EIT conductivity maps from interrogating the sensing mesh; and generating, in real time, strain distribution and strain directionality data of the MSK region of interest based on the EIT conductivity maps.

Abstract: An electronic device including a substrate a group III-V layer on or above the substrate, wherein the III-V layer has an in-plane lattice constant that is greater than that of gallium nitride or wherein the III-V layer is at least partially relaxed; and an active region including a coherently strained group III-V channel layer on or above the III-V layer; wherein electron mobility in the channel layer is increased by the strain. Structures with an in-plane lattice constant that is smaller than that of gallium nitride are used for increasing the hole mobility by strain.

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

Abstract: The present invention provides compounds and pharmaceutical compositions of peptidomimetic ligands. The peptidomimetic ligands can be conjugated with phosphonate drugs. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.

Abstract: Methods are provided for emulating disease in a microfluidic system with a releasable interfacial film component that allows communication between non-gel aqueous solutions to emulate natural physiological conditions. The systems and methods emulate cellular communication in a disease state in a more accurate aqueous environment and provide data on the interaction between the cells that can be used to develop a treatment for a subject in need. The systems and methods also can be used to assess the effect of a particular treatment, such as a drug therapy, radiation therapy, or a combination thereof, for example. The systems and methods can show how a particular therapy is affected by any of several known factors including, but not limited to, the sex of the subject, the age of the subject, hereditary factors or other genetic predispositions, as well as perhaps other physiological states of the subject, or a combination thereof.

Abstract: This invention relates to methods and systems for reducing the concentration of SOx and/or NOx in gas streams.

Abstract: Pointing interfaces that can be used to assemble/disassemble instruments/payloads from a spacecraft/host are disclosed. The disclosed interfaces provide structural, communications, power, and fluid connections (for thermal control). Such interfaces also provide active and passive vibration isolation capability for precision pointing. They can further act as an interface to the launch vehicle for secondary delivery of the instrument/payload to the spacecraft.

Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications.

Abstract: The present application relates to probiotic compositions, e.g., comprising at least one bacterial strain selected from: Streptococcus thermophilus, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, KE99, and Lactobacillus bulgaricus, optionally wherein the at least one bacterial strain is either alive or sonicated.

Abstract: The present disclosure provides methods of alleviating a symptom or delaying disease progression of a condition associated with a thiamine deficiency, a thiamine-dependent enzyme, or an associated cofactor and/or treating a condition associated with a thiamine deficiency, a thiamine-dependent enzyme, or an associated cofactor. The present methods result in alleviating a symptom or delaying disease progression of the condition associated with the thiamine deficiency, the thiamine-dependent enzyme, or the associated cofactor, treatment of the condition associated with the thiamine deficiency, the thiamine-dependent enzyme, or the associated cofactor, and/or alteration of a phenotypic characteristic of the condition associated with the thiamine deficiency, the thiamine-dependent enzyme, or the associated cofactor.

Abstract: A boundary learning optimization tool for training neural networks with accurate models of parameterized flexure using a minimal number of numerically generated performance solutions generated from different design instantiations of those topologies. Performance boundaries are output by the neural network in optimization steps, with geometric parameters varied from smallest allowable feature sizes to largest geometrically compatible feature sizes for given constituent materials. The plotted performance boundaries define the design spaces of flexure systems toward allowing designers to visually identify which geometric versions of their synthesized topologies best achieve desired combinations of performance capabilities.

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

Abstract: Provided herein are compositions and methods of making high density nucleic acid polymers.

Abstract: A nanowire electrode array has a plurality of vertical nanowires extending from a substrate, each of the nanowires including a core of unitary first dielectric material that also covers the substrate and is unitary with the substrate. Each core has a sharp sub-100 nm diameter tip and a wider base, electrode leads on sidewalls to the tip of the nanowire, and second dielectric covering the electrode leads. The tips in the array can penetrate individual cells in cell culture, such as a mini-brain culture. The substrate can include a window for simultaneous optical imaging and electrophysiological recording.

Abstract: Described herein are embodiments relating to manipulation of populations and sex ratio in populations through DNA sequence modifications.

Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.

Abstract: An apparatus, system and methods that allows simultaneous acquisition of tunneling currents and Raman spectra for molecular sensing, detection, identification or sequencing. The apparatus has a substrate with a surface channel or transverse bore for orienting a target between electrodes of a single molecule break junction. A Raman spectrometer, with excitation source and detector, is configured to simultaneously interrogate the target at the junction. A data acquisition unit receives spectral data from the Raman spectrometer detector and electrical data from the electrodes individually or simultaneously. The acquired data is recorded and analyzed used to identify features of the target and the identification may be assisted by machine learning algorithms.

Abstract: Methods of treating resectable head and neck cancer based on analyses of blood and tumor samples collected over the course of a clinical trial and during follow-up after the clinical trial. Omic or multi-plex molecular tools were used to analyze the tissues and identify objective molecular markers and pathogenic mechanisms associated with favorable or unfavorable outcomes. These analyses form the basis for a treatment strategy that improves outcomes by tailoring the treatment to the molecular features of individual patients' blood samples and tumors. This method for personalized treatment distinguishes between subjects who respond to neoadjuvant anti-PD-1/L1 therapy and patients who do not respond to such neoadjuvant therapy, so that treatment is tailored to the subject's responder profile. This approach avoids exposing patients to unnecessary toxicity, and avoids delaying surgical resection when no advantage will be gained by delaying surgery to allow for neoadjuvant therapy.

Abstract: The present disclosure relates to the field of biotechnology, and, more specifically, to systems and methods for identifying novel pore-forming toxins (PFTs) based on protein structures and sequences.