Abstract: A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).

Abstract: Provided herein are recombinant virus systems comprising two or more coordinatedly regulated viral vectors. Methods for treating a cell proliferative disorder using these systems are also provided. The compositions and methods provided herein provide more efficient and coordinated delivery of larger transgenes and/or larger quantities of a tansgene than previous methods by avoiding receptor interference and/or superinfection resistance, thereby enabling progressive replication of both vectors and efficient gene delivery by each vector.

Abstract: An optical modulator and method of fabricating an optical modulator. The optical modulator includes a first optical waveguide with an input port configured to receive an unmodulated optical signal and an output port; an magneto-optical layer located adjacent to the first optical waveguide, wherein optical attributes of the magneto-optical layer vary in relation to a magnetic field: and a conductive layer located in close proximity to a portion of the magneto-optical layer located adjacent to the first optical waveguide, wherein current injected to the conductive layer generates a magnetic field oriented perpendicular to a direction of propagation of light within the first optical waveguide.

Abstract: Described herein, inter alia, are peptide containing polymers, and methods of making and using the same.

Abstract: A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.

Abstract: Described herein is a hierarchical learning-based method, called HierPINN-EM, to solve the Korhonen equations for multi segment interconnects for fast EM failure analysis. HierPINN-EM split the physics laws into two levels and solve the PDE equations step by step. The lower level employs supervised learning to train a DNN model which takes parameterized neurons as inputs and serves as a universal parameterized EM stress solver for single segment wires. The upper level employs physics-informed loss function to train a separate DNN model at the boundaries of all wire segments to enforce the stress and atom flux continuities at internal junctions in interconnects.

Abstract: This invention provides a structure-based design method for making antisense oligonucleotides (ASOs) and ASOs made by this method. ASOs are an emerging class of drugs that are especially suitable for fighting a wide range of diseases. They are single-stranded synthetic oligonucleotides that specifically bind target RNAs and elicit desired biological and therapeutic effects. Conventional ASO design strategies do not adequately address this problem. The instant invention includes structure-based ASO designs that target RNAs critical in a variety of diseases.

Abstract: A system for direct air capture (DAC) of carbon dioxide uses a liquid CO2-absorbent solvent that enables the hybridization of a cooling tower with CO2 DAC systems. A liquid solvent such as monoethanolamine (MEA) is added to cooling water to absorb CO2 from ambient air, the cooling water is used for its original purpose, and CO2 is recovered from the cooling water in a novel process. Initially, this combination of CO2 absorbent and cooling water would appear to be undesirable, since liquid CO2 solvents such as MEA are hygroscopic, and cooling towers reject heat via evaporation. However, an absorbent concentration range was identified where CO2 could be still absorbed and water evaporated, and a novel process for absorbent solvent regeneration was created.

Abstract: The invention provides, for the first time, cells that express truncated or modified Fc Receptor proteins (e.g. CD16t, CD32t, or CD64t) to evade antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The cells may be pluripotent cells, including hypoimmune pluripotent cells (HIP) or ABO blood type O Rhesus Factor negative HIP cells (HIPO?), that express a truncated or modified Fc Receptor. The invention encompasses cells derived from the pluripotent cells as well as primary cells. The cells may also be differentiated cells, including chimeric antigen receptor (CAR) cells, T cells, natural killer (NK) cells, endothelial cells, dopaminergic neurons, neuroglial cells, pancreatic islet cells, pancreatic beta cells, thyroid cells, fibroblasts, hepatocytes, cardiomyocytes, or retinal pigment endothelium cells.

Abstract: We report human cerebellar organoids which recapitulate the major milestones of cerebellar development including generating bona fide Purkinje cells, as well as methods of making and using these human cerebellar organoids such as uses in drug target identification and drug screening. In various embodiments, we report a human organoid model (human cerebellar organoids [hCerOs]) capable of developing the complex cellular diversity of the fetal cerebellum, including a human-specific rhombic lip progenitor population that have never been generated in vitro prior to our study. 2-month-old hCerOs form distinct cytoarchitectural features, including laminar organized layering, and create functional connections between inhibitory and excitatory neurons that display coordinated network activity. Long-term culture of hCerOs allows healthy survival and maturation of Purkinje cells that display molecular and electrophysiological hallmarks of their in vivo counterparts, addressing a long-standing challenge in the field.

Abstract: Systems, computer-readable medium, methods and apparatus, and/or devices to causally quantify the potentially heterogeneous direct effect of a marketing program on focal individuals (e.g., egos) and the indirect effect on those connected to the focal ones (e.g., alters). A primary data structure (focal individual or ego) may be connected to multiple secondary data structures (alters) by a primary-to-secondary linkage net. Moreover, different secondary data structures may be connected together by a secondary-to-secondary linkage net, and some secondary data structures maybe connected to multiple primary data structures. Thus, in a complicated arrangement of connections, an input change directed at a single primary data structure may have both direct effects thereon, and complex indirect effects on secondary data structures. The systems, computer-readable medium, methods and apparatus, and/or devices provide mechanisms to evaluate these effects.

Abstract: Proton beams can deliver a highly targeted radiation dose to a narrow volume defined by their Bragg peaks. However, Bragg peak range uncertainties persist during dose delivery. Fortunately, pulsed proton beams generate protoacoustic emissions proportional to absorbed proton energy, thereby encoding dosimetry information in a detectable acoustic wave. The present embodiments provide methods and apparatuses to derive and model protoacoustic imaging with an ultrasound transducer, and examine the frequency characteristics of protoacoustic emissions, which are crucial parameters in imaging resolution.

Abstract: A deep learning-based digital staining method and system are disclosed that provides a label-free approach to create a virtually-stained microscopic images from quantitative phase images (QPI) of label-free samples. The methods bypass the standard histochemical staining process, saving time and cost. This method is based on deep learning, and uses a convolutional neural network trained using a generative adversarial network model to transform QPI images of an unlabeled sample into an image that is equivalent to the brightfield image of the chemically stained-version of the same sample. This label-free digital staining method eliminates cumbersome and costly histochemical staining procedures, and would significantly simplify tissue preparation in pathology and histology fields.

Abstract: The present invention is directed to the fabrication and use of phase-change material (PCM) membranes in microvalves for microfluidic systems. The microvalve may be fabricated by using a tissue-sectioning instrument to slice a thin membrane of PCM off of a block of PCM. The membrane may then be sandwiched between a plurality of microfluidic flow sections to act as a microvalve. At room temperature, the membrane may exist in a solid state to act as a zero-leakage seal and microvalve. Applying heat to the membrane may bring the membrane to a melting point, causing it to reach a liquid state. The microvalve in the liquid state may experience a surface tension effect by a material of the microfluidic flow sections, causing it to displace from a flow path and allow a fluid to pass from one microfluidic flow section to another.

Abstract: A method of generating an output trajectory of an ego vehicle includes recording trajectory data of the ego vehicle and pedestrian agents from a scene of a training environment of the ego vehicle. The method includes identifying at least one pedestrian agent from the pedestrian agents within the scene of the training environment of the ego vehicle causing a prediction-discrepancy by the ego vehicle greater than the pedestrian agents within the scene. The method includes updating parameters of a motion prediction model of the ego vehicle based on a magnitude of the prediction-discrepancy caused by the at least one pedestrian agent on the ego vehicle to form a trained, control-aware prediction objective model. The method includes selecting a vehicle control action of the ego vehicle in response to a predicted motion from the trained, control-aware prediction objective model regarding detected pedestrian agents within a traffic environment of the ego vehicle.

Abstract: A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications.

Abstract: The invention provides LFA3 polypeptide molecules, e.g., variant LFA3 fusion polypeptide molecules. The invention includes uses, and associated methods of using the LFA3 polypeptide molecules.

Abstract: An ultrasound measurement device includes: a processing device and multiple ultrasound sensors that capture tomographic information of a physiological structure. The ultrasound sensors include a first ultrasound sensor including a first transducer having a first frequency response with a first resonant frequency, and a second ultrasound sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response.

Abstract: Building blocks for implementing Vector-by-Matrix Multiplication (VMM) are implemented with analog circuitry including non-volatile memory devices (flash transistors) and using in-memory computation. In one example, improved performance and more accurate VMM is achieved in arrays including multi-gate flash transistors when computation uses a control gate or the combination of control gate and word line (instead of using the word line alone). In another example, very fast weight programming of the arrays is achieved using a novel programming protocol. In yet another example, higher density and faster array programming is achieved when the gate(s) responsible for erasing devices, or the source line, are re-routed across different rows, e.g., in a zigzag form. In yet another embodiment a neural network is provided with nonlinear synaptic weights implemented with nonvolatile memory devices.

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.