Patents Assigned to Calimmune Inc.
  • DUAL VECTOR FOR INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS
    Publication number: 20120201794
    Abstract: The present invention provides an expression vector for preventing or inhibiting HIV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HIV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.
    Type: Application
    Filed: May 26, 2010
    Publication date: August 9, 2012
    Applicant: Calimmune Inc.
    Inventors: Irvin Chen, Dong Sung An, Michelle L. Millington, Maureen P. Boyd, Geoffrey P. Symonds, Louis Randall Breton