Patents Assigned to Caliper Technologies Corp.
-
Patent number: 7426442Abstract: Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that is a series of measurements for a sample at a scanning location over time can be displayed on a display device in a series of bands. Additionally, the series of bands for multiple samples can be aligned on the display device.Type: GrantFiled: July 27, 2004Date of Patent: September 16, 2008Assignee: Caliper Technologies, Corp.Inventor: Steven J. Gallagher
-
Publication number: 20080006533Abstract: The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular, the devices and methods of the invention utilize microchannels of specific cross-sectional configuration and of specific arrangement as well as application of AC current orthogonal to the direction of fluid flow, in order to prevent/ameliorate formation of precipitate blockages in microfluidic devices.Type: ApplicationFiled: June 18, 2007Publication date: January 10, 2008Applicant: Caliper Technologies Corp.Inventor: Andrea Chow
-
Publication number: 20080003690Abstract: The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular, the devices and methods of the invention utilize microchannels of specific cross-sectional configuration and of specific arrangement as well as application of AC current orthogonal to the direction of fluid flow, in order to prevent/ameliorate formation of precipitate blockages in microfluidic devices.Type: ApplicationFiled: June 18, 2007Publication date: January 3, 2008Applicant: Caliper Technologies Corp.Inventor: Andrea Chow
-
Publication number: 20070261479Abstract: The present invention relates to novel methods and systems for determining the interaction of molecules using the phenomenon of Taylor-Aris dispersion present in fluid flow in conduits. The method involves relating a change in dispersion of molecules to their level of interaction. The present invention also relates to an assay method using Taylor-Aris dispersion in a microfluidic system in order to examine molecular interactions in a variety of chemical and biochemical systems.Type: ApplicationFiled: May 18, 2007Publication date: November 15, 2007Applicant: Caliper Technologies, Corp.Inventors: Michael Spaid, Jeffrey Wolk
-
Patent number: 7276330Abstract: Time dependent iterative reactions are carried out in microscale fluidic channels by configuring the channels such that reagents from different sources are delivered to a central reaction zone at different times during the analysis, allowing for the performance of a variety of time dependent, and/or iterative reactions in simplified microfluidic channels. Exemplary analyses include the determination of dose responses for biological and biochemical systems.Type: GrantFiled: April 17, 2003Date of Patent: October 2, 2007Assignee: Caliper Technologies Corp.Inventors: Calvin Y. H. Chow, J. Wallace Parce
-
Patent number: 7247274Abstract: The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular the devices and methods of the invention utilize microchannels of specific cross-sectional configuration and of specific arrangement as well as application of AC current orthogonal to the direction of fluid flow, in order to preventing/ameliorating formation of precipitate blockages in microfluidic devices.Type: GrantFiled: November 12, 2002Date of Patent: July 24, 2007Assignee: Caliper Technologies Corp.Inventor: Andrea W. Chow
-
Publication number: 20050189224Abstract: The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields. Light from periodically spaced regions along a channel in the microfluidic system are received by a photodetector. The intensity of light received by the photodetector is modulated by the movement of species bands through the channel under electrophoretic forces. By Fourier analysis, the velocity of each species band is determined and the identification of the species is made by its electrophoretic mobility in the channel.Type: ApplicationFiled: June 25, 2003Publication date: September 1, 2005Applicant: Caliper Technologies Corp.Inventor: J. Parce
-
Publication number: 20050074898Abstract: This invention provides reagent array chips having, e.g., reagents spotted at a high density onto self-assembled monolayers (SAMs) for consistent and high recovery. The invention teaches, e.g., methods to make and use reagent array chips to screen for protease substrates. Identified substrates can, e.g., then be used to screen for modulators of the protease activity and to establish quantitative assays for the protease.Type: ApplicationFiled: December 18, 2003Publication date: April 7, 2005Applicant: Caliper Technologies Corp.Inventors: Sammy Datwani, Sherri Biondi, Ravi Vijayendran, Tex Horning, Shodana Song
-
Publication number: 20050011761Abstract: Methods of concentrating materials within microfluidic channel networks by moving materials into regions in which overall velocities of the material are reduced, resulting in stacking of the material within those reduced velocity regions. These methods, devices and systems employ static fluid interfaces to generate the differential velocities, as well as counter-current flow methods, to concentrate materials within microscale channels.Type: ApplicationFiled: December 5, 2003Publication date: January 20, 2005Applicant: Caliper Technologies Corp.Inventors: Ring-Ling Chien, Benjamin Wang, Persefoni Kechagia
-
Publication number: 20050003554Abstract: Samples of materials used in industrial processes are analyzed to determine the concentration of certain materials of interest. The quantitative analysis of samples for these materials is provided without the need for manual methods such as titration. Indicators such as fluorescent dyes for which the intensity of fluorescence is indicative of the concentration of a material of interest are used. The dyes are made to fluoresce by means of a light source, and a photomultiplier or other detector capable of measuring light intensity detects the resulting fluorescence. The intensity of fluorescence in the sample is compared to the intensities of fluorescence produced by samples with known concentrations of the material of interest to determine the concentration of the material of interest of the sample.Type: ApplicationFiled: May 10, 2004Publication date: January 6, 2005Applicant: Caliper Technologies Corp.Inventor: Michael Brasseur
-
Publication number: 20040241733Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Type: ApplicationFiled: April 8, 2004Publication date: December 2, 2004Applicants: Caliper Technologies Corp., Caliper Life Sciences, Inc.Inventors: J. Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
-
Publication number: 20040238401Abstract: A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.Type: ApplicationFiled: June 2, 2003Publication date: December 2, 2004Applicant: Caliper Technologies Corp.Inventors: Michael Greenstein, Colin B. Kennedy, Huan L. Phan, Stephan Bianchi, Jonathan R. Harris, Daren W. Hebold, Robert A. Howard, Andrew L. Zee
-
Publication number: 20040188254Abstract: Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated (and can be concentrated) by altering the applied pressure and electric fields in the various channel segments of the channel networks.Type: ApplicationFiled: December 22, 2003Publication date: September 30, 2004Applicant: Caliper Technologies Corp.Inventor: Michael Spaid
-
Publication number: 20040144421Abstract: Methods devices and systems that employ non-mechanical valve modules for controllably directing fluid and other material movement through integrated microscale channel networks. These non-mechanical valve modules apply forces that counter the driving forces existing through a given channel segment, via fluidly connected channel segments, so as to selectively arrest flow of material within the given channel segment.Type: ApplicationFiled: November 5, 2003Publication date: July 29, 2004Applicant: Caliper Technologies Corp.Inventors: J. Wallace Parce, Andrea W. Chow
-
Publication number: 20040141884Abstract: Microfluidic devices and systems that include keying, registration or indication elements that communicate a functionality of the microfluidic device to the instrumentation which is used in conjunction with these devices. Indicator elements include structural indicators, electrical indicators, optical indicators and chemical indicators. Different indicator elements are indicative of different functionalities, e.g., applications, new vs. used, and the like.Type: ApplicationFiled: November 5, 2003Publication date: July 22, 2004Applicants: Caliper Technologies Corp., Agilent Technologies Inc.Inventors: Garrett Unno, Colin B. Kennedy, Patrick Kaltenbach, Manfred Berndt
-
Publication number: 20040123649Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.Type: ApplicationFiled: December 5, 2003Publication date: July 1, 2004Applicant: Caliper Technologies Corp.Inventors: Michael Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill
-
Patent number: 6756019Abstract: The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports. Rings are optionally disposed between the cover layer and the body structure and circumferentially around pairs of aligned apertures and ports. The devices also optionally include conductive coatings and membranes. The invention additionally provides methods of controlling the delivery of a composition of material into a microfluidic device.Type: GrantFiled: April 6, 2000Date of Patent: June 29, 2004Assignee: Caliper Technologies Corp.Inventors: Robert S. Dubrow, Colin B. Kennedy, Robert Nagle, David Chazan, Ernest C. W. Lee, Khushroo Gandhi, Calvin Y. H. Chow
-
Publication number: 20040096960Abstract: Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members.Type: ApplicationFiled: June 25, 2003Publication date: May 20, 2004Applicant: Caliper Technologies Corp.Inventors: Tammy Burd Mehta, Anne R. Kopf-Sill, J. Wallace Parce, Andrea W. Chow, Luc J. Bousse, Michael R. Knapp, Theo T. Nikiforov, Steve Gallagher
-
Publication number: 20040089548Abstract: Multiphasic microfluidic apparatus for performing product fluid manipulation and separation in a single continuous unit are provided. Related methods, kits, and compositions are also provided.Type: ApplicationFiled: November 5, 2003Publication date: May 13, 2004Applicant: Caliper Technologies Corp.Inventors: Tammy Burd Mehta, Anne R. Kopf-Sill
-
Patent number: 6733645Abstract: Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and detect the individual analytes. Signal areas are summed for each individual analyte to quantitate the total analyte amount. Separate measurements of the total analyte sample are also used to determine total analyte concentration.Type: GrantFiled: April 12, 2001Date of Patent: May 11, 2004Assignee: Caliper Technologies Corp.Inventor: Calvin Y. H. Chow