Patents Assigned to Calipher Technologies Corp.
  • Methods of manufacturing microfabricated substrates
    Patent number: 6425972
    Abstract: The present invention is directed to improved methods and apparatuses for manufacturing microfabricated devices, and particularly, microfluidic devices. In general the methods and apparatuses of the invention provide improved methods of bonding substrates together by applying a vacuum to the space between the substrates during the bonding process.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: July 30, 2002
    Assignee: Calipher Technologies Corp.
    Inventor: Richard J. McReynolds
  • Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
    Patent number: 6326083
    Abstract: Hydrophilic protein adsorption resistant coatings for microfluidic devices are provided. Additionally, microfluidic devices and methods of manufacturing microfluidic devices that include the coatings are provided.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: December 4, 2001
    Assignee: Calipher Technologies Corp.
    Inventors: Hua Yang, Steven A. Sundberg
  • Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
    Patent number: 6004515
    Abstract: The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: December 21, 1999
    Assignee: Calipher Technologies Corp.
    Inventors: John Wallace Parce, Anne R. Kopf-Sill