Patents Assigned to Cambrex Charles City, Inc.
  • Patent number: 10370382
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), wherein R1 is as described in the description, by demethylation of a corresponding O-methyl derivative.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: August 6, 2019
    Assignee: Cambrex Charles City, Inc.
    Inventors: Pär Holmberg, Michael Robert Tracey, Zhiming Eric Dong
  • Publication number: 20180354961
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), wherein R1 is as described in the description, by demethylation of a corresponding O-methyl derivative.
    Type: Application
    Filed: July 26, 2016
    Publication date: December 13, 2018
    Applicant: Cambrex Charles City, Inc.
    Inventors: Pär Holmberg, Michael Robert Tracey, Zhiming Eric Dong
  • Patent number: 9981978
    Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2 and R3 are as described in the description, by conversion of a corresponding allylic alcohol.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: May 29, 2018
    Assignee: Cambrex Charles City, Inc.
    Inventors: Michael Tracey, Pär Holmberg, Belén Lindberg Martín Matute, Antonio Bermejo Gómez, Jan-Erling Bäckvall
  • Patent number: 9981979
    Abstract: There is provided a novel process for the preparation of a hydrocodone salt. In particular, there is provided a novel process for the preparation of a free-flowing slurry of a hydrocodone salt, for example, a free-flowing slurry of hydrocodone bitartrate hemipentahydrate.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: May 29, 2018
    Assignee: Cambrex Charles City, Inc.
    Inventors: Michael Robert Tracey, Zhiming Eric Dong
  • Publication number: 20170327511
    Abstract: There is provided a novel process for the preparation of a hydrocodone salt. In particular, there is provided a novel process for the preparation of a free-flowing slurry of a hydrocodone salt, for example, a free-flowing slurry of hydrocodone bitartrate hemipentahydrate.
    Type: Application
    Filed: November 2, 2015
    Publication date: November 16, 2017
    Applicant: Cambrex Charles City, Inc.
    Inventors: Michael Robert Tracey, Zhiming Eric Dong
  • Patent number: 8779191
    Abstract: The invention provides methods and compositions for preparing lisdexamfetamine and salts thereof. More particularly, the invention provides, for example, methods of preparing lisdexamfetamine from D-amphetamine.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: July 15, 2014
    Assignee: Cambrex Charles City, Inc.
    Inventors: Michael J. Bauer, Gary Richard Callen, Judi Christine Humphrey, Todd Jeffrey Johnson, Matthew Wendell Schiesher
  • Patent number: 8614346
    Abstract: The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention provides methods of preparing an amphetamine conjugate from a chloramphetamine intermediate.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: December 24, 2013
    Assignee: Cambrex Charles City, Inc.
    Inventors: Paul Alan Jass, Todd Jeffrey Johnson, Jason Scott Douglas, Matthew Wendell Schiesher
  • Patent number: 8039621
    Abstract: Type I anhydrous aripiprazole is prepared by dissolving aripiprazole (or an acid salt thereof) in an alcoholic solvent, optionally containing water, at elevated temperature, adding seed crystals of Type 1 anhydrous aripiprazole to the solution, cooling the mixture, and isolating crystals aripiprazole and drying the isolated crystals to obtain low moisture Type 1 anhydrous aripiprazole.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: October 18, 2011
    Assignee: Cambrex Charles City, Inc.
    Inventor: Brian T. Becicka
  • Publication number: 20100317857
    Abstract: Type I anhydrous aripiprazole is prepared by dissolving aripiprazole (or an acid salt thereof) in an alcoholic solvent, optionally containing water, at elevated temperature, adding seed crystals of Type 1 anhydrous aripiprazole to the solution, cooling the mixture, and isolating crystals aripiprazole and drying the isolated crystals to obtain low moisture Type 1 anhydrous aripiprazole.
    Type: Application
    Filed: October 24, 2007
    Publication date: December 16, 2010
    Applicant: CAMBREX CHARLES CITY, INC.
    Inventor: Brian T. Becicka
  • Patent number: 7705184
    Abstract: A method in which a crude chlorinated product of a phenylpropanolamine, preferably prepared by reacting thionyl chloride with the phenylpropanolamine, is purified by contacting an aqueous solution of the crude product with carbon. The carbon-treated solution of the crude chlorinated product of a phenylpropanolamine is catalytically hydrogenated to the corresponding amphetamine derivative.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: April 27, 2010
    Assignee: Cambrex Charles City, Inc.
    Inventors: Greg Buenger, Jason Douglas, Paul Jass, Erik Michalson, Matthew Schiesher
  • Patent number: 7345191
    Abstract: A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z? are defined herein.
    Type: Grant
    Filed: February 26, 2005
    Date of Patent: March 18, 2008
    Assignee: Cambrex Charles City, Inc.
    Inventors: Paul Alan Jass, Jason Scott Douglas
  • Patent number: 7294736
    Abstract: A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z? are defined herein.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: November 13, 2007
    Assignee: Cambrex Charles City, Inc.
    Inventors: Paul Alan Jass, Jason Scott Douglas
  • Patent number: 7247744
    Abstract: A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z? are defined herein.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: July 24, 2007
    Assignee: Cambrex Charles City, Inc.
    Inventor: Paul Alan Jass
  • Patent number: 6828336
    Abstract: A nicotine product having a nicotine release rate of not less than 70% over a 10 minute period as well as a process to produce such product. Such product is produced by a process comprising the steps of (a) preparing an aqueous solution of an organic polyol; (b) mixing said aqueous solution of the organic polyol with a cation exchange resin selected from the group consisting of (i)—a methacrylic, weakly acidic type of resin containing carboxylic functional groups (ii)—polystyrene, strongly acidic type of resin containing sulfonic functional groups and (iii)—polystyrene, intermediate acidic type of resin containing phosphonic functional groups thereby forming a cation exchange resin mixture having some of its ion exchange sites partially blocked with said polyol; (c) admixing with said mixture of step (b) an aqueous solution of nicotine to form a nicotine-coated cation exchange resin admixture; and (d) removing water from said admixture.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: December 7, 2004
    Assignee: Cambrex Charles City, Inc.
    Inventor: John A. Walling
  • Patent number: 6586449
    Abstract: A nicotine product having a nicotine release rate of not less than 70% over a 10 minute period as well as a process to produce such product Such product is produced by a process comprising the steps of (a) preparing an aqueous solution of an organic polyol; (b) mixing said aqueous solution of the organic polyol with a cation exchange resin selected from the group consisting of (i)—a methacrylic, weakly acidic type of resin containing carboxylic functional groups (ii)—polystyrene, strongly acidic type of resin containing sulfonic functional groups and (iii)—polystyrene, intermediate acidic type of resin containing phosphonic functional groups thereby forming a cation exchange resin mixture having some of its ion exchange sites partially blocked with said polyol; (c) admixing with said mixture of step (b) an aqueous solution of nicotine to form a nicotine-coated cation exchange resin admixture; and (d) removing water from said admixture.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: July 1, 2003
    Assignee: Cambrex Charles City, Inc.
    Inventor: John Allen Walling