Patents Assigned to Cambrex Charles City, Inc.
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Patent number: 11136331Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.Type: GrantFiled: October 12, 2018Date of Patent: October 5, 2021Assignee: CAMBREX CHARLES CITY, INC.Inventors: Par Holmberg, Lars Eklund, David Adams, Michael Letourneau, Margus Eek, Alo Soone
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Patent number: 10370382Abstract: There is provided a novel process for the preparation of a compound of formula (I), wherein R1 is as described in the description, by demethylation of a corresponding O-methyl derivative.Type: GrantFiled: July 26, 2016Date of Patent: August 6, 2019Assignee: Cambrex Charles City, Inc.Inventors: Pär Holmberg, Michael Robert Tracey, Zhiming Eric Dong
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Publication number: 20180354961Abstract: There is provided a novel process for the preparation of a compound of formula (I), wherein R1 is as described in the description, by demethylation of a corresponding O-methyl derivative.Type: ApplicationFiled: July 26, 2016Publication date: December 13, 2018Applicant: Cambrex Charles City, Inc.Inventors: Pär Holmberg, Michael Robert Tracey, Zhiming Eric Dong
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Patent number: 9981979Abstract: There is provided a novel process for the preparation of a hydrocodone salt. In particular, there is provided a novel process for the preparation of a free-flowing slurry of a hydrocodone salt, for example, a free-flowing slurry of hydrocodone bitartrate hemipentahydrate.Type: GrantFiled: November 2, 2015Date of Patent: May 29, 2018Assignee: Cambrex Charles City, Inc.Inventors: Michael Robert Tracey, Zhiming Eric Dong
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Patent number: 9981978Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2 and R3 are as described in the description, by conversion of a corresponding allylic alcohol.Type: GrantFiled: July 23, 2014Date of Patent: May 29, 2018Assignee: Cambrex Charles City, Inc.Inventors: Michael Tracey, Pär Holmberg, Belén Lindberg Martín Matute, Antonio Bermejo Gómez, Jan-Erling Bäckvall
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Publication number: 20170327511Abstract: There is provided a novel process for the preparation of a hydrocodone salt. In particular, there is provided a novel process for the preparation of a free-flowing slurry of a hydrocodone salt, for example, a free-flowing slurry of hydrocodone bitartrate hemipentahydrate.Type: ApplicationFiled: November 2, 2015Publication date: November 16, 2017Applicant: Cambrex Charles City, Inc.Inventors: Michael Robert Tracey, Zhiming Eric Dong
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Patent number: 8779191Abstract: The invention provides methods and compositions for preparing lisdexamfetamine and salts thereof. More particularly, the invention provides, for example, methods of preparing lisdexamfetamine from D-amphetamine.Type: GrantFiled: December 20, 2010Date of Patent: July 15, 2014Assignee: Cambrex Charles City, Inc.Inventors: Michael J. Bauer, Gary Richard Callen, Judi Christine Humphrey, Todd Jeffrey Johnson, Matthew Wendell Schiesher
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Patent number: 8614346Abstract: The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention provides methods of preparing an amphetamine conjugate from a chloramphetamine intermediate.Type: GrantFiled: June 18, 2010Date of Patent: December 24, 2013Assignee: Cambrex Charles City, Inc.Inventors: Paul Alan Jass, Todd Jeffrey Johnson, Jason Scott Douglas, Matthew Wendell Schiesher
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Patent number: 8039621Abstract: Type I anhydrous aripiprazole is prepared by dissolving aripiprazole (or an acid salt thereof) in an alcoholic solvent, optionally containing water, at elevated temperature, adding seed crystals of Type 1 anhydrous aripiprazole to the solution, cooling the mixture, and isolating crystals aripiprazole and drying the isolated crystals to obtain low moisture Type 1 anhydrous aripiprazole.Type: GrantFiled: October 24, 2007Date of Patent: October 18, 2011Assignee: Cambrex Charles City, Inc.Inventor: Brian T. Becicka
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Publication number: 20100317857Abstract: Type I anhydrous aripiprazole is prepared by dissolving aripiprazole (or an acid salt thereof) in an alcoholic solvent, optionally containing water, at elevated temperature, adding seed crystals of Type 1 anhydrous aripiprazole to the solution, cooling the mixture, and isolating crystals aripiprazole and drying the isolated crystals to obtain low moisture Type 1 anhydrous aripiprazole.Type: ApplicationFiled: October 24, 2007Publication date: December 16, 2010Applicant: CAMBREX CHARLES CITY, INC.Inventor: Brian T. Becicka
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Patent number: 7705184Abstract: A method in which a crude chlorinated product of a phenylpropanolamine, preferably prepared by reacting thionyl chloride with the phenylpropanolamine, is purified by contacting an aqueous solution of the crude product with carbon. The carbon-treated solution of the crude chlorinated product of a phenylpropanolamine is catalytically hydrogenated to the corresponding amphetamine derivative.Type: GrantFiled: May 15, 2009Date of Patent: April 27, 2010Assignee: Cambrex Charles City, Inc.Inventors: Greg Buenger, Jason Douglas, Paul Jass, Erik Michalson, Matthew Schiesher
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Patent number: 7345191Abstract: A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z? are defined herein.Type: GrantFiled: February 26, 2005Date of Patent: March 18, 2008Assignee: Cambrex Charles City, Inc.Inventors: Paul Alan Jass, Jason Scott Douglas
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Patent number: 7294736Abstract: A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z? are defined herein.Type: GrantFiled: April 9, 2004Date of Patent: November 13, 2007Assignee: Cambrex Charles City, Inc.Inventors: Paul Alan Jass, Jason Scott Douglas
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Patent number: 7247744Abstract: A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z? are defined herein.Type: GrantFiled: July 25, 2006Date of Patent: July 24, 2007Assignee: Cambrex Charles City, Inc.Inventor: Paul Alan Jass
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Patent number: 6828336Abstract: A nicotine product having a nicotine release rate of not less than 70% over a 10 minute period as well as a process to produce such product. Such product is produced by a process comprising the steps of (a) preparing an aqueous solution of an organic polyol; (b) mixing said aqueous solution of the organic polyol with a cation exchange resin selected from the group consisting of (i)—a methacrylic, weakly acidic type of resin containing carboxylic functional groups (ii)—polystyrene, strongly acidic type of resin containing sulfonic functional groups and (iii)—polystyrene, intermediate acidic type of resin containing phosphonic functional groups thereby forming a cation exchange resin mixture having some of its ion exchange sites partially blocked with said polyol; (c) admixing with said mixture of step (b) an aqueous solution of nicotine to form a nicotine-coated cation exchange resin admixture; and (d) removing water from said admixture.Type: GrantFiled: May 5, 2003Date of Patent: December 7, 2004Assignee: Cambrex Charles City, Inc.Inventor: John A. Walling
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Patent number: 6586449Abstract: A nicotine product having a nicotine release rate of not less than 70% over a 10 minute period as well as a process to produce such product Such product is produced by a process comprising the steps of (a) preparing an aqueous solution of an organic polyol; (b) mixing said aqueous solution of the organic polyol with a cation exchange resin selected from the group consisting of (i)—a methacrylic, weakly acidic type of resin containing carboxylic functional groups (ii)—polystyrene, strongly acidic type of resin containing sulfonic functional groups and (iii)—polystyrene, intermediate acidic type of resin containing phosphonic functional groups thereby forming a cation exchange resin mixture having some of its ion exchange sites partially blocked with said polyol; (c) admixing with said mixture of step (b) an aqueous solution of nicotine to form a nicotine-coated cation exchange resin admixture; and (d) removing water from said admixture.Type: GrantFiled: May 28, 2002Date of Patent: July 1, 2003Assignee: Cambrex Charles City, Inc.Inventor: John Allen Walling