Patents Assigned to Cambrex Karlskoga
  • Processes for the preparation of compounds, such as 3-arylbutanals, useful in the synthesis of medetomidine
    Patent number: 10053420
    Abstract: There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: August 21, 2018
    Assignee: Cambrex Karlskoga AB
    Inventors: Lars Eklund, Margus Eek, Ramesh Ekambaram, Ants Maasalu
  • PROCESSES FOR THE PREPARATION OF COMPOUNDS, SUCH AS 3-ARYLBUTANALS, USEFUL IN THE SYNTHESIS OF MEDETOMIDINE
    Publication number: 20180009744
    Abstract: There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.
    Type: Application
    Filed: January 29, 2016
    Publication date: January 11, 2018
    Applicant: Cambrex Karlskoga AB
    Inventors: Lars Eklund, Margus Eek, Ramesh Ekambaram, Ants Maasalu
  • Process for preparing lacosamide and related compounds
    Patent number: 9771317
    Abstract: There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: September 26, 2017
    Assignees: Cambrex Karlskoga AB, Cambrex Profarmaco Milano
    Inventors: Stefano Radaelli, Giuseppe Zurlo, Lars Eklund, Margus Eek, Ants Maasalu, Malle Schmidt
  • Processes for producing benzophenone derivatives
    Patent number: 9085519
    Abstract: There is provided a process for the preparation of a compound of formula I, wherein X, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b, R3c, R3d and R3e are as described in the description. Such compounds may, for example, be useful medicament (or intermediates for medicaments).
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: July 21, 2015
    Assignee: Cambrex Karlskoga AB
    Inventors: Lars Eklund, Jonas Nilsson
  • Processes for preparing 4-substituted imidazoles
    Patent number: 8962862
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 24, 2015
    Assignee: Cambrex Karlskoga AB
    Inventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
  • PROCESS FOR PREPARING HYDROXYLAMINES AND MEDICAMENTS
    Publication number: 20140206761
    Abstract: There is provided a process for the preparation of a compound of formula II, wherein R1, R2, R3 and R4 are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.
    Type: Application
    Filed: March 24, 2014
    Publication date: July 24, 2014
    Applicant: Cambrex Karlskoga AB
    Inventors: Lars O. HANSSON, Anders BERGH, Lars EKLUND
  • Process for preparing benzofurans
    Patent number: 8779201
    Abstract: There is provided a process for the preparation of a compound of formula (I), wherein R1, R2, R3, R4, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: July 15, 2014
    Assignee: Cambrex Karlskoga AB
    Inventor: Lars Eklund
  • NEW PROCESSES FOR PREPARING 4-SUBSTITUTED IMIDAZOLES
    Publication number: 20140187789
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.
    Type: Application
    Filed: July 20, 2012
    Publication date: July 3, 2014
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
  • PROCESS FOR THE PREPARATION OF LACOSAMIDE
    Publication number: 20130317109
    Abstract: There is provided a process for the preparation of Lacosamide (which is a useful medicament) of formula I, which comprises an enantioselective enzymatic acylation.
    Type: Application
    Filed: November 25, 2011
    Publication date: November 28, 2013
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Cecilia Kvarnström Branneby, Margus Eek
  • Process for preparing benzofurans
    Patent number: 8519165
    Abstract: There is provided a process for the preparation of a compound of formula (I), wherein R1, R2, R3, R4, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone. Intermediate steps of the process comprise formulae according to (II) and (III).
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: August 27, 2013
    Assignee: Cambrex Karlskoga AB
    Inventor: Lars Eklund
  • NEW PROCESSES FOR PRODUCING BENZOPHENONE DERIVATIVES
    Publication number: 20130035514
    Abstract: There is provided a process for the preparation of a compound of formula I, wherein X, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b, R3c, R3d and R3e are as described in the description. Such compounds may, for example, be useful medicament (or intermediates for medicaments).
    Type: Application
    Filed: January 19, 2011
    Publication date: February 7, 2013
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Lars Eklund, Jonas Nilsson
  • NEW PROCESS FOR PREPARING HYDROXYLAMINES AND MEDICAMENTS
    Publication number: 20120122971
    Abstract: There is provided a process for the preparation of a compound of formula II, wherein R1, R2, R3 and R4 are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.
    Type: Application
    Filed: April 6, 2010
    Publication date: May 17, 2012
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Lars O. Hansson, Anders Bergh, Lars Eklund
  • MICROWAVE APPARATUS
    Publication number: 20120108818
    Abstract: The present invention relates to a microwave apparatus, a method or use of the apparatus and a method of carrying out chemical reactions on a continuous basis with the apparatus, wherein the apparatus is particularly suitable for microwave-assisted organic synthesis.
    Type: Application
    Filed: January 26, 2010
    Publication date: May 3, 2012
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Birger Hagberg, Lars Eklund
  • NEW PROCESS FOR PREPARING DIKETONES AND MEDICAMENTS
    Publication number: 20120046356
    Abstract: There is provided a process for the preparation of a compound of formula (III), wherein X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone. There is also provided a process for the preparation of a compound of formula (I).
    Type: Application
    Filed: October 2, 2009
    Publication date: February 23, 2012
    Applicant: CAMBREX KARLSKOGA AB
    Inventor: Lars Eklund
  • PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED ALKALOIDS
    Publication number: 20120041022
    Abstract: There is provided a process for the preparation of a single enantiomer of anhydroecgonine (of formula I): or a salt thereof, in which R1 is as defined in the description. Such single enantiomers may, for example, be useful intermediates in the synthesis of pharmaceuticals, in which the enantioselectivity is important.
    Type: Application
    Filed: January 29, 2010
    Publication date: February 16, 2012
    Applicant: CAMBREX KARLSKOGA
    Inventors: Lars O. Hansson, Anders Bergh
  • PROCESS FOR PREPARING BENZOFURANS
    Publication number: 20100292319
    Abstract: There is provided a process for the preparation of a compound of formula (I), wherein R1, R2, R3, R4, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone. Intermediate steps of the process comprise formulae according to (II) and (III).
    Type: Application
    Filed: October 2, 2008
    Publication date: November 18, 2010
    Applicant: CAMBREX KARLSKOGA AB
    Inventor: Lars Eklund
  • Thermostable Omega-Transaminases
    Patent number: 7319027
    Abstract: Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound to a non-terminal, chirally substituted, carbon atom.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: January 15, 2008
    Assignee: Cambrex Karlskoga AB
    Inventors: Sachin Pannuri, Sanjay Venkatesh Kamat, Abraham Rogelio Martin-Garcia
  • Thermostable omega-transaminases
    Patent number: 7267969
    Abstract: Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound to a non-terminal, chirally substituted, carbon atom.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: September 11, 2007
    Assignee: Cambrex Karlskoga
    Inventors: Sachin Pannuri, Sanjay Venkatesh Kamat, Abraham Rogelio Martin Garcia