Abstract: Therapeutic compositions containing a compound of the formula: ##STR1## wherein: R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, hydroxy, alkoxy f 1 to 4 carbon atoms, acyloxy of 1 to 4 carbon atoms, halo, or nitro, or R.sub.2 and R.sub.3 together form --OCH.sub.2 O--; or the corresponding acylated derivatives wherein there are one or more acyl groups in the hydantoin moiety and each acyl group contains from 1 to 20 carbon atoms, and the use of said compounds to control virus infections, in particular those caused by entero and foot and mouth disease viruses of the Picorna group.

Abstract: A process for preparing ampicillin trihydrate is disclosed which comprises acylating silylated 6-aminopenicillanic acid with D(-)-.alpha.-phenylglycylchloride hydrochloride directly in the silylation reaction mixture in the presence of urea as an acid acceptor, hydrolyzing the reaction product and precipitating ampicillin-trihydrate from the resulting aqueous solution. The amounts of reactants, in particular of solvents and water, are adjusted to provide good yields of a product of high purity.

Abstract: A continuous process of contacting crude oils, particularly triglyceride oils, with an acid for the purpose of removing phosphatides and trace metals is disclosed. The acid is introduced into a stream of heated oil immediately ahead of mixing means, such as a static-mixer, capable of achieving an acid droplet size smaller than 10 microns in diameter. The interfacial surface provided by these microscopic droplets allows the acid-oil contacting process to occur essentially instantaneously, requiring less acid and less acid-oil residence-time. The process is useful in treating crude oils prior to alkali-refining or prior to a bleaching treatment in preparation for steam-refining.

Abstract: Triglyceride oils are bleached rapidly and efficiently in a continuous system wherein a stream of the oil is preheated to bleaching temperature and is introduced into a mixing zone in such manner as to provide a swirling motion, bleaching adsorbent containing moisture is added to the surface of the swirling hot oil and water vapor or steam derived from the moisture in the adsorbent forms a protective atmosphere above the surface of the oil to protect it from oxidation. The oil-adsorbent mixture is pumped continuously from the mixer to a bleaching zone consisting of one or more static mixers, which may be unobstructed pipe sections, under flow conditions providing an average residence time of approximately one minute. The flow regime in the bleaching zone may be laminar or turbulent. Optionally, the oil-adsorbent mixture may flow continuously from the mixing zone to a vacuum dryer where it is deaerated and dried to optimum moisture content for bleaching prior to being pumped to the bleaching zone.

Abstract: A process for preparing a high-melting form of CDCA having a melting point of at least about 160.degree. C. is disclosed which comprises the steps of:(a) suspending at least one form of CDCA having a melting point of below 160.degree. C. in a non-aromatic liquid hydrocarbon, preferably cyclohexane, to form a suspension having a boiling point of at least 65.degree. C.;(b) heating the suspension to a sufficiently high temperature of between about 65.degree. and about 140.degree. C., preferably between about 75.degree. and about 100.degree. C., during a sufficiently long period of time for converting substantially all of the CDCA into the high-melting form;(c) recovering the high-melting form of CDCA from the suspension.Low-melting amorphous and/or crystalline forms of CDCA, as well as CDCA-solvent inclusion complexes can be treated in the above-described process. The high-melting CDCA is obtained in form of a substantially granular powder, which is suitable to be formulated into therapeutical compositions.

Abstract: A method of isolating chenodeoxycholic acid from hog bile is provided, which comprises the steps of treating the hog bile under saponifying conditions separating the bile acids from the water-soluble constituents of the saponified bile; esterifying the bile acids to obtain a mixture of bile acid esters; isolating from the mixture of bile acid esters the hyodeoxycholic acid ester as its adduct with a compound selected from the group consisting of benzene and toluene; treating the remaining bile acid esters under acetylating conditions; isolating the hyocholic acid ester triacetate; isolating the chenodeoxycholic acid ester diacetate; treating the chenodeoxycholic acid ester diacetate under saponifying conditions; isolating the chenodeoxycholic acid thus obtained; and, optionally purifying the chenodeoxycholic acid.The method described yields chenodeoxycholic acid of exceedingly high purity, which may be used in the treatment of gallstones by their dissolution in vivo.

Abstract: Novel acetal and ketal derivatives of ascorbic acid having utility in controlling the formation of undesirable nitrosamines in cooked, nitrite cured meat products are disclosed. Meat treating compositions containing these compounds, methods of treating meats with same and meat products containing same are also disclosed.

Abstract: A process for preparing low chromium content gelatine from a chrome stock containing trivalent chromium which comprises treating a trivalent chromium-containing stock with a solution of a compound which forms coordination complexes with trivalent chromium present in said stock, conditioning the thus treated stock to partially depolymerize the collagen network of said stock, oxidizing a substantial portion of the residual trivalent chromium in said stock to the hexavalent state, washing said stock containing hexavalent chromium to partially remove said hexavalent chromium, extracting gelatine from the remaining stock, and subjecting the extracted gelatine to ion exchange treatment to remove further hexavalent chromium.

Abstract: Novel acetal and ketal derivatives of ascorbic acid having utility in controlling the formation of undesirable nitrosamines in cooked, nitrite cured meat products are disclosed. Meat treating compositions containing these compounds, methods of treating meats with same and meat products containing same are also disclosed.

Abstract: Immunoglobulins for new-born piglets to provide them with antibodies effective against disease are administered as a dried particulate serum obtained from animal blood and having a reduced sodium chloride content. Such a serum is palatable to piglets and can be orally administered along with feed-stuffs.

Abstract: Nitroxide derivatives of 1,2-dihydro- and 1,2,3,4-tetrahydro-6-alkoxyquinolines are used for reducing or eliminating the formation of undesirable nitrosamines which are generated when nitrite cured meat, such as bacon, is cooked at the temperatures usually attained during frying, grilling or broiling.

Abstract: The formation of nitrosamines in cooked, cured meat products is reduced or eliminated by using certain 1, 2, 3, 4-tetrahydro-6-alkoxyquinoline compounds in the curing mixtures or to treat the cured meat.

Abstract: The formation of nitrosamines in cooked, cured meat products is reduced or eliminated by using certain aromatic secondary amines, such as p-alkoxy-N-alkylaminobenzenes, in the curing mixtures or to treat the cured meat.

Abstract: A method of treating a virus infection caused by an enterovirus of the Pina group which comprises administering to a mammal susceptible to or infected with said virus an effective amount of a compound of the formula: ##STR1## wherein: R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, hydroxy, alkoxy of 1 to 4 carbon atoms, acyloxy of 1 to 4 carbon atoms, halo, or nitro, or R.sub.2 and R.sub.3 together form -OCH.sub.2 O-; or the corresponding acylated derivatives wherein there are one or more acyl groups in the hydantoin moiety and each acyl group contains from 1 to 20 carbon atoms.

Abstract: A method of treating foot and mouth virus infections in cattle comprising ministering to an animal susceptible to or infected with said virus an effective amount of a compound of the formula: ##STR1## wherein: R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, hydroxy, alkoxy of 1 to 4 carbon atoms, acyloxy of 1 to 4 carbon atoms, halo, or nitro, or R.sub.2 and R.sub.3 together form -OCH.sub.2 O-; or the corresponding acylated derivatives wherein there are one or more acyl groups in the hydantoin moiety and each acyl group contains from 1 to 20 carbon atoms.

Abstract: Highly purified deoxyribonuclease is obtained by a simple process which comprises adsorption of deoxyribonuclease from a crude or partially purified solution of the enzyme on a column of concanavalin A-agarose, followed by elution of the adsorbed deoxyribonuclease with a carbohydrate solution and recovery of the deoxyribonuclease in solid form from such solution.

Abstract: Amine derivatives of 1,2,3,4-tetrahydro-1,4-alkanonaphthalenes, and the use of such compounds to control viral infections, particularly influenza viruses, in warm-blooded animals are disclosed. Pharmaceutical compositions containing an effective amount of the novel compounds and a pharmaceutically acceptable carrier are also disclosed.

Abstract: The formation of nitrosamines in cooked, cured meat products is reduced or eliminated by using certain aromatic primary amines, such as p-alkoxyaminobenzenes, in the curing mixtures or to treat the cured meat.

Abstract: A rotary inclined tubular drier for puffing or expanding borax and a process for the production of puffed or expanded borax beads of desired physical characteristics. A rotatable tube is mounted on bearing wheels and surrounded by a fixed, close-fitting, insulated tube having electrical heating elements running lengthwise attached to its inside wall. The rotatable tube is fed continuously with granular borax feedstock by a vibratory feeder from its higher end and the puffed borax is discharged into a discharge chute from the lower end of the tube. A counter current of dry air is maintained by a suction hood at the high end of the tube, and borax is prevented from adhering to the interior of the tube by an adjustable, spring-loaded, internal scraper. The temperature of the drier is controlled by means of a pyrometer incorporated into a scraper support rod on the interior of the tube.

Abstract: Therapeutic compositions containing a compound of the formula: ##STR1## wherein: R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, hydroxy, alkoxy f 1 to 4 carbon atoms, acyloxy of 1 to 4 carbon atoms, halo, or nitro, or R.sub.2 and R.sub.3 together form --OCH.sub.2 O--; or the corresponding acylated derivatives wherein there are one or more acyl groups in the hydantoin moiety and each acyl group contains from 1 to 20 carbon atoms, and the use of said compounds to control virus infections, in particular those caused by viruses of the Picorna group.