Abstract: This disclosure relates to a cellular-based therapies for modulating the level of regulatory T cells (Treg) and/or the level of pro-inflammatory T cells (Th17/Th1). To provide these therapeutic effects, a combination comprising at least one a cellular pro-tolerogenic preparation and at least one a cellular pro-inflammatory preparation are administered sequentially.
Type:
Grant
Filed:
July 10, 2015
Date of Patent:
February 18, 2020
Assignee:
CANADIAN BLLOOD SERVICES
Inventors:
Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku