Patents Assigned to Cancer Prevention and Cure, Ltd.
  • Patent number: 11474104
    Abstract: The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: October 18, 2022
    Assignee: CANCER PREVENTION AND CURE, LTD.
    Inventors: Sung H. Baek, Robert T. Streeper, Elzbieta Izbicka
  • Publication number: 20190072554
    Abstract: The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. Measurements of these biomarkers are inputted into a classification system such as a support vector machine or AdaBoost to assist in determining the likelihood that an individual has a lung disease. Kits comprising agents for detecting the biomarkers and combination of biomarkers, as well as systems that assist in diagnosing lung diseases are also provided.
    Type: Application
    Filed: April 24, 2018
    Publication date: March 7, 2019
    Applicant: Cancer Prevention and Cure, Ltd.
    Inventors: Joel Michalek, Elzbieta Izbicka, Robert T. Streeper, Chris Louden
  • Patent number: 9952220
    Abstract: The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. Measurements of these biomarkers are inputted into a classification system such as a support vector machine or AdaBoost to assist in determining the likelihood that an individual has a lung disease. Kits comprising agents for detecting the biomarkers and combination of biomarkers, as well as systems that assist in diagnosing lung diseases are also provided.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: April 24, 2018
    Assignee: Cancer Prevention and Cure, Ltd.
    Inventors: Joel Michalek, Elzbieta Izbicka, Robert T Streeper, Chris Louden
  • Patent number: 9933429
    Abstract: The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: April 3, 2018
    Assignee: Cancer Prevention and Cure, LTD.
    Inventors: Sung H Baek, Robert T. Streeper, Elzbieta Izbicka
  • Publication number: 20140024553
    Abstract: The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-smail cell lung cancer or reactive airway disease. Measurements of these biomarkers are inputted into a classification system such as a support vector machine or AdaBoost to assist in determining the likelihood that an individual has a lung disease. Kits comprising agents for detecting the biomarkers and combination of biomarkers, as well as systems that assist in diagnosing lung diseases are also provided.
    Type: Application
    Filed: April 30, 2012
    Publication date: January 23, 2014
    Applicant: Cancer Prevention and Cure, Ltd.
    Inventors: Joel Michalek, Elzbieta Izbicka, Robert T. Streeper, Chris Louden
  • Patent number: 8541183
    Abstract: The invention provides biomarkers and combinations of biomarkers that are useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: September 24, 2013
    Assignee: Cancer Prevention and Cure, Ltd.
    Inventors: Robert T. Streeper, Elzbieta Izbicka, Sung H. Baek
  • Publication number: 20120302455
    Abstract: The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subjects response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
    Type: Application
    Filed: March 12, 2010
    Publication date: November 29, 2012
    Applicant: CANCER PREVENTION AND CURE., LTD
    Inventors: Robert T. Streeper, Elzbieta Izbicka, Sung H. Baek
  • Patent number: 7888051
    Abstract: A method of identifying altered biomarker expression levels in a human serum specimen to diagnose asthma or non-small celled lung cancers in humans. The existence of asthma or non-small celled lung cancers in a patient can be determined by subjecting a blood sample from the patient to a simple blood test to determine the expression levels of certain specific biomarkers. The expression levels of the specific biomarkers are compared to ranges of expression levels for the same biomarkers which are indicative of individuals known to have asthma, non-small cell lung cancers, or neither. Comparing the expression levels will determine the existence or non-existence of asthma or non-small cell lung cancer.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: February 15, 2011
    Assignee: Cancer Prevention and Cure, Ltd.
    Inventors: Robert T. Streeper, Elzbieta Izbicka, Sung H. Baek
  • Publication number: 20100009386
    Abstract: The invention provides biomarkers and combinations of biomarkers that are useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
    Type: Application
    Filed: March 12, 2009
    Publication date: January 14, 2010
    Applicant: CANCER PREVENTION AND CURE, LTD.
    Inventors: Robert T. STREEPER, Elzbieta IZBICKA, Sung H. BAEK
  • Publication number: 20090068685
    Abstract: A method of identifying altered biomarker expression levels in a human serum specimen to diagnose asthma or non-small celled lung cancers in humans. The existence of asthma or non-small celled lung cancers in a patient can be determined by subjecting a blood sample from the patient to a simple blood test to determine the expression levels of certain specific biomarkers. The expression levels of the specific biomarkers are compared to ranges of expression levels for the same biomarkers which are indicative of individuals known to have asthma, non-small cell lung cancers, or neither. Comparing the expression levels will determine the existence or non-existence of asthma or non-small cell lung cancer.
    Type: Application
    Filed: September 11, 2008
    Publication date: March 12, 2009
    Applicant: CANCER PREVENTION AND CURE, LTD.
    Inventors: Robert T. Streeper, Elzbieta Izbicka, Sung H. Baek
  • Publication number: 20090069189
    Abstract: A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known to have non-small cell lung cancers and asthma, as diagnosed by a physician. Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identities of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
    Type: Application
    Filed: September 11, 2008
    Publication date: March 12, 2009
    Applicant: Cancer Prevention and Cure, Ltd.
    Inventors: Robert T. Streeper, Elzbieta Izbicka, Sung H. Baek