Abstract: A method for treatment of tumors to which antibody A5B7 binds is disclosed. A5B7 is a monoclonal antibody which binds to carcinoembryonic antigen. The method comprises administering to a host in need of such treatment an effective amount of a system which comprises a conjugate comprising: antibody A5B7 or a humanized version of A5B7 linked to an enzyme selected from the group consisting of carboxypeptidase G2 (CPG2), nitroreductase, a human enzyme, a non-human enzyme rendered non-immunogenic in man and a humanized catalytic antibody; and a prodrug convertible under the influence of the conjugate into a cytotoxic drug.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
November 4, 1997
Assignee:
Cancer Research Campaign Tech. Ltd. & Zeneca Ltd.
Inventors:
Kenneth D. Bagshawe, Gordon T. Rogers, Surinder K. Sharma
Abstract: A treatment for tumors to which antibody A5B7 binds is disclosed. A5B7 is a monoclonal antibody which binds to carcinoembryonic antigen. The treatment comprises administering to a host in need of such treatment an effective amount of a system which comprises: a conjugate comprising antibody A5B7 or a humanized version of A5B7 linked to an enzyme selected from the group consisting of carboxypeptidase G2 (CPG2), nitroreductase, a human enzyme, a non-human enzyme rendered non-immunogenic in man and a humanized catalytic antibody; and a prodrug convertible under the influence of the conjugate into a cytotoxic drug.
Type:
Grant
Filed:
September 28, 1994
Date of Patent:
May 27, 1997
Assignees:
Cancer Research Campaign Tech. Ltd., Zeneca Ltd.
Inventors:
Kenneth D. Bagshawe, Gordon T. Rogers, Surinder K. Sharma