Abstract: A nucleic acid construct is provided for delivery into living cells in vivo for inducing an immune response in a patient to an antigen; the construct directing the expression of a fusion protein, said fusion protein comprising said antigen and an adjuvant sequence derived from a plant viral coat protein. Methods for making such constructs, and methods of using such constructs for the treatment of infectious disease, cancer and B cell malignancy, are provided.
Abstract: A method for increasing the systemic exposure of cells selected from tumor cells and normal cells to an orally administered pharmaceutically active compound, wherein a bioenhancer comprising an inhibitor of BCRP is orally administered concomitantly with said orally administered pharmaceutically active compound, and in which method the inhibitor is administered simultaneously with the pharmaceutical compound.
Type:
Grant
Filed:
November 19, 2001
Date of Patent:
April 18, 2006
Assignee:
Cancer Research Ventures Limited
Inventors:
Johannes Henricus Matthias Schellens, Alfred Hermanus Schinkel
Abstract: The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing compounds, of formula (I), wherein
wherein x is —NH—NH—CH2R1 and R1 denotes C8 to C20 alkyl.
Type:
Grant
Filed:
October 18, 1999
Date of Patent:
September 4, 2001
Assignee:
Cancer Research Ventures Limited
Inventors:
Eberhard Amtmann, Norbert Frank, Gerhard Sauer, Gerhard Schilling