Abstract: The present invention is related to a method to be performed with one tissue type, wherein a specific combination of hydrogel features has been pre-selected for the said one tissue type to be tested. The present invention is also related to a kit of parts to perform said method.

Abstract: The present invention is related to a biofunctional three-dimensional hydrogel suitable for the expansion of freshly isolated or frozen intestinal cells and the formation of intestinal organoids therefrom, that avoids the use of a naturally-derived matrix such as Matrigel and provides intestinal organoids suitable for clinical applications and generated in a commercially feasible manner. The present invention is also related to a kit of parts comprising said hydrogel in combination with a suitable culture medium, and to a method of making organoids and expanding cells from freshly isolated or frozen intestinal cells with said kit of parts.

Abstract: A catheter apparatus includes a hollow needle having a first end and a sharpened tip at a second end. A catheter having a blunt end is telescopically received in the needle. A catheter hub is attached to the catheter and spaced from the blunt end. The catheter hub is disposed adjacent the needle hub in an elastomeric housing. A method of inserting a catheter in a patient's vein includes a step of providing a catheter apparatus in which the elastomeric housing biases the hubs, needle, and catheter in a rest position in which the catheter protrudes from the tip of the needle. The method also includes the steps of squeezing the housing to displace the catheter hub relative to the needle hub, causing the tip of the needle to protrude beyond the blunt end of the catheter, inserting the needle and catheter in the patients's vein, and releasing the housing to allow the catheter assembly to return to the rest position.

Abstract: A salve includes a water-miscible, hydrophilic cream vehicle, 1-22% by weight a-DFMO, and no absorption enhancer. The salve is preferably contained in an ointment tube permanently sealed at one end to preclude exposure to light and air. The salve is applied as a preventative in an appropriate amount twice daily to skin exposed to actinic radiation. An initial application of a salve including 10% by weight A-DFMO is preferred to minimize the risk of skin irritation without compromising the therapeutic value of the salve. The salve shows no systemic uptake, thereby eliminating systemic toxicities that result from other techniques for administering the drug.

Abstract: Methods, compositions and a kit for deactivating spills or leaks of HIV infected blood or anticancer drugs by applying to the leak or spill an aqueous solution containing calcium hypochlorite or sodium hypochlorite as the active ingredient. In order to thicken the aqueous solution and thus keep it from spreading beyond its intended area of application, the solution of calcium hypochlorite contains methylcellulose. In addition to chemically deactivating the active anticancer drug, the solution of the invention also effectively decolorizes it, thus preventing permanent stains on any surface or fabric with which the anticancer drug comes into contact.