Abstract: This disclosure relates to new compositions and methods for making cannabinoid formulations. In one embodiment, this disclosure provides water soluble compositions comprising a first purified cannabinoid and Vitamin E TPGS. In one embodiment, the disclosure herein comprises a method of making powders comprising heatings material to a first temperature and a second temperature.

Abstract: This disclosure relates generally to cannabinoid derivatives, pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives.

Abstract: The current application relates to cannabinoid derivatives of formula (I) and pharmaceutical compositions comprising the same. The cannabinoid derivative can be used for the treatment of diseases associated with cannabinoid receptor such as pain, ADHD/ADD, alcohol use disorder, anxiety disorder, and dementias.

Abstract: Disclosed are methods for synthesizing cannabielsoin (CBE) and or analogs thereof. In particular, the present disclosure provides methods for synthesizing CBE or analogs thereof comprising steps of providing a cannabinoid composition that comprises cannabidiol (CBD) or analogs thereof; combining the cannabinoid composition with an agent comprising a ketone functional group; and contacting the cannabinoid composition with an oxidizing agent or exposing the cannabinoid composition to electromagnetic radiation.

Abstract: A heater assembly for a vaporizer including a heat exchanger with an interior surface having at least one ridge and groove, and a heater positioned in the bore. An air management system for a vaporizer including a valve that allows air to be drawn through a valve inlet and pumped through a valve outlet with a pump or drawn through the valve outlet and inlet with external suction. A system and method for generating a workflow sequence for a vaporizer. The system and method including receiving task selections arranged in a task order, and generating a workflow sequence that is configured to instruct the vaporizer to sequentially perform the tasks associated with the task selections in the task order. A vaporizer that is configured to receive task selections arranged in a task order and sequentially perform the tasks associated with the task selections in the task order.

Abstract: The synthesis of a range of pentylbezene-1,3-diol compounds of formula I is disclosed. These compounds bind to cannabinoid 1 and 2 receptors (CB1 and CB2), and are thus presumed to be useful in modulating the activity of such receptors. Accordingly, the use of such synthetic cannabinoids in the treatment of various disorders mediated by CB1 and CB2 is contemplated.

Abstract: This disclosure relates to cannabinoid derivatives having the structure of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor in subject in need thereof, wherein the cannabinoid receptor is one or more of CB1, CB2, 5HT1A, 5HT2A, GPR18, GPR55, GPR119, TRPV1, TRPV2, PPAR? or a ?-opioid receptor.

Abstract: Disclosed herein is a method for continuously preparing crystalline cannabinoid particles. The method includes preparing a cannabinoid-rich solution that comprises a first cannabinoid and inducing the cannabinoid-rich solution to a supersaturated state in which the first cannabinoid has a supersaturated concentration that is greater than a corresponding saturation concentration of the first cannabinoid. The method includes flowing the cannabinoid-rich solution into a continuous stirred-tank reactor (CSTR) in a continuous manner, mixing the cannabinoid-rich solution under turbulent mixing conditions to form a plurality of crystalline cannabinoid particles and a cannabinoid-depleted solution within the CSTR, and discharging the plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution from the CSTR in a continuous manner to provide a flow rate through the CSTR.

Abstract: Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides high purity CBG, CBGA, and analogs thereof.

Abstract: A cone staging apparatus for production of smoking articles includes (a) a frame, and (b) a cone pallet releasably supported by the frame. The cone pallet includes a plurality of cavities. Each cavity has an open upper end for receiving a cone therein. The apparatus further includes (c) a cone magazine adjacent the frame for holding a supply of cones. The cone magazine includes at least one escapement alignable over the open upper end of a respective cavity of the cone pallet to facilitate transferring a single cone from the supply of cones to the respective cavity.

Abstract: An apparatus with a projection defining first and second openings and a channel between the openings. An interior surface adjacent the channel tapers inwardly from the first opening to the second opening, and a shearing edge is positioned adjacent the second opening. A method of using the apparatus to separate protuberances of a plant from an elongate portion of the plant by pulling the elongate portion through the channel. Another apparatus with first and second counter-rotating rollers. Each roller having alternating projecting portions and valleys and oriented so that projecting portions of one roller are aligned with valleys of the other roller as the rollers rotate. A method of using the rollers to deform an elongate portion of a plant between the projecting portions of one roller and the valleys of the other roller.

Abstract: Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides highly purity CBG, CBGA, and analogs thereof.

Abstract: This disclosure relates to new compositions and methods for making cannabinoid formulations. In one embodiment, this disclosure provides water soluble compositions comprising a first purified cannabinoid and Vitamin E TPGS. In one embodiment, the disclosure herein comprises a method of making powders comprising heatings material to a first temperature and a second temperature.

Abstract: A charging structure for a vaporizer. The charging structure includes a housing, a first electrical contact coupled to and extending outward from a first end of the housing, a spacer coupled to the first electrical contact, and a second electrical contact coupled to and extending outward from the spacer. The first electrical contact includes an exposed outer surface that extends in a continuous loop. The second electrical contact includes an exposed side surface that extends in a continuous loop and an end surface coupled to the side surface. Both the side surface and the end surface are electrically conductive. A vaporizer including the charging structure.

Abstract: Disclosed herein is a method of converting a THC-rich cannabinoid mixture that comprises at least about 20% THC into a CBN-rich cannabinoid mixture that comprises at least about 2.0% CBN. The method comprises contacting the cannabinoid mixture with a benzoquinone reagent under reaction conditions comprising: (i) a reaction temperature that is within a target reaction-temperature range; and (ii) a reaction time that is within a target reaction-time range, such that at least a portion of the of the THC in the THC-rich cannabinoid mixture is converted into CBN.

Abstract: This disclosure relates to new plants and methods for increasing and decreasing synthesis of cannabinoids. The plants disclosed herein comprise unnatural ratios and concentrations of cannabinoids in plants of genus Cannabis. The methods disclosed herein comprise manipulating the biosynthetic pathway of cannabinoids to produce plants of genus Cannabis with unnatural ratios and concentrations of cannabinoids.

Abstract: A method of compacting a smokeable product in a cone for production of smoking articles is disclosed. The method includes aligning a respective cone held in a cone pallet with a pin. The cone contains a volume of the smokeable product and has an open upper end. The method further includes advancing the pin into the volume of the smokeable product through the open upper end of the cone; and withdrawing the pin from the volume of the smokeable product. The volume of the smokeable product has an empty column formed therein when the pin is withdrawn. The method further includes vibrating the cone pallet to induce collapse of the smokeable product into the column.

Abstract: Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides highly purity CBG, CBGA, and analogs thereof.

Abstract: The invention relates to a method for producing an extract from cannabis plant matter, containing tetrahydrocannabinol, cannabidiol and optionally the carboxylic acids thereof. According to said method, the dried plant matter is ground and subjected to a CO2 extraction and the primary extract obtained is separated. The invention method permits ?8 or ?9 tetrahydrocannabinol to be selectively obtained both from industrial hemp and from drug-producing hemp, optionally after dissolving the primary extract in ethanol, separating undesirable waxes and removing the solvent under reduced pressure.