Abstract: A liquid storage and release chip provided according to the present application includes a structural layer and an elastic cover sheet. An end surface of one side of the structural layer is provided with a liquid storage cell and a liquid quantitation cell, the liquid storage cell and the liquid quantitation cell are separated by a common partition wall, and the partition wall is provided with a valve opening passing through end surfaces of two sides of the structural layer. The elastic cover sheet is attached to the structural layer and covers the liquid storage cell, the liquid quantitation cell and the valve opening in a sealed manner, and the valve opening allows a spool to be inserted in the valve opening in a sealed manner to push up a portion, covering the valve opening, of the elastic cover sheet.

Abstract: In one aspect, disclosed herein are devices, systems, and methods for assessing human health states based on non-shadow imaging of sclera, or whites, of one or both eyes. In one aspect, the device is an on-body device. In one aspect, the system comprises a positioning aperture, an illuminating apparatus, an imaging apparatus, and/or a processing apparatus. In one aspect, the process only takes a short period of time to take images of the sclera without any operation of splicing multiple images. In one aspect, the device or system improves the quality of images by avoiding the formation of reflection of the illuminating apparatus on the images of the sclera. In a further aspect, the system can utilize the sclera images to obtain information of eye diseases and to predict the physiological and pathological changes in the health status of subject or diagnostic results, which can provide helpful information for medical diagnosis.

Abstract: In one aspect, disclosed herein are devices, systems, and methods for assessing human health states based on non-shadow imaging of sclera, or whites, of one or both eyes. In one aspect, the device is an on-body device. In one aspect, the system comprises a positioning aperture, an illuminating apparatus, an imaging apparatus, and/or a processing apparatus. In one aspect, the process only takes a short period of time to take images of the sclera without any operation of splicing multiple images. In one aspect, the device or system improves the quality of images by avoiding the formation of reflection of the illuminating apparatus on the images of the sclera. In a further aspect, the system can utilize the sclera images to obtain information of eye diseases and to predict the physiological and pathological changes in the health status of subject or diagnostic results, which can provide helpful information for medical diagnosis.

Abstract: In one aspect, provided herein are set of primers and use of the same for the detection of SNPs associated with diabetes. In certain embodiments, the primers used to detect SNP sites associated with diabetes comprise Primer Set 1 to Primer Set 47. The experiments show: the genotyping results of the SNP sites associated with diabetes can be accurately detected by the primers disclosed herein, and the risk of individuals can be comprehensively evaluated and the result is more accurate than the single site analysis. In addition, SNPs disclosed herein are verified as associated with type 2 diabetes and its complications, which are especially suitable for the prevention and individualized treatment for type 2 diabetes in East Asian, for example, in China.