Patents Assigned to Capsugel Belgium NV
  • Dosage form articles
    Patent number: 9980905
    Abstract: A dosage form article suitable for oral administration may include more than one compartment, each formed by a plurality of distinct segments of the dosage form article. The dosage form article may also include a signaling means and a drug, wherein the signaling means and the drug are each stored in different compartments physically separated from one another. Both the drug and the signaling means may be wholly incorporated within the dosage form article, the respective compartments being arranged to fully enclose the drug and signaling means only when at least two of the plurality of distinct segments are connected.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: May 29, 2018
    Assignee: Capsugel Belgium NV
    Inventors: Hilde Buydts, Stefaan Jaak Vanquickenborne
  • Acid resistant banding solution for acid resistant two piece hard capsules
    Patent number: 9980918
    Abstract: The present disclosure relates to acid resistant banding solutions for two piece hard capsules endowed with acid resistant properties, and methods of making and using acid resistant banding solutions. The present disclosure also relates, in part, to methods for banding such acid resistant capsules which provides an acid resistant seal between the capsule parts and achieves increased acid resistance in vitro.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: May 29, 2018
    Assignee: Capsugel Belgium NV
    Inventors: Xiongwei He, Dominique Nicolas Cade
  • Bulk enteric capsule shells
    Patent number: 9925148
    Abstract: The present disclosure relates to aqueous compositions for use in the manufacture of capsule shells endowed with bulk enteric properties. The present disclosure also relates, in part, to aqueous dispersions suitable for the implementation of said manufacturing process, and to enteric capsule shells and hard capsules obtained therewith.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: March 27, 2018
    Assignee: Capsugel Belgium NV
    Inventors: Hassan Benameur, Dominique Nicolas Cade, Sophie Schreiber
  • CURCUMIN SOLID LIPID PARTICLES AND METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20180036248
    Abstract: Solid lipid particles comprising a lipid hydrophobic matrix and from about 5 wt. % to about 30 wt. % of curcumin, and methods of making and treatment thereof.
    Type: Application
    Filed: October 18, 2017
    Publication date: February 8, 2018
    Applicant: Capsugel Belgium NV
    Inventors: Christopher Diorio, John Lokhnauth
  • SEPARABLE CAPSULE
    Publication number: 20170360716
    Abstract: The present disclosure relates to a separable hard capsule for containing a medication. The capsule may be opened by finger force and used, for example, by pediatric and geriatric patients.
    Type: Application
    Filed: September 5, 2017
    Publication date: December 21, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Hilde Buydts, Stefaan Jaak Vanquickenborne
  • LIPID MULTIPARTICULATE FORMULATIONS
    Publication number: 20170354599
    Abstract: Disclosed are various embodiments of lipid multiparticulate compositions comprising at least one active agent, a low flow point excipient, and a high flow point excipient.
    Type: Application
    Filed: November 24, 2015
    Publication date: December 14, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Christopher Diorio, John Lokhnauth, Chang Lee
  • COLLOIDAL DISPERSION COMPRISING HPMCAS
    Publication number: 20170281780
    Abstract: The present disclosure relates to compositions of an aqueous colloidal dispersion of hydroxypropyl methyl cellulose acetate succinate (HPMCAS), and methods for making such colloidal dispersions.
    Type: Application
    Filed: August 19, 2015
    Publication date: October 5, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Jonathan Leonard Cape, Warren Kenyon Miller, Dwayne Thomas Friesen, Hassan Benameur, Maryline Clauzel, David Thomas Vodak
  • Separable capsule
    Patent number: 9775813
    Abstract: The present disclosure relates to a separable hard capsule for containing a medication. The capsule may be opened by finger force and used, for example, by pediatric and geriatric patients.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: October 3, 2017
    Assignee: Capsugel Belgium NV
    Inventors: Hilde Buydts, Stefaan Jaak Vanquickenborne
  • STABLE DOSAGE FORM ARTICLES FOR ORAL ADMINISTRATION
    Publication number: 20170239187
    Abstract: Novel delivery systems for highly hygroscopic active materials is disclosed. The delivery system comprising a hard capsule filled with a liquid composition consisting of a hygroscopic active material dispersed in a non-aqueous carrier. The carrier comprising, or consisting of, one or more lipophilic lipid substances and one or more rheology modifiers.
    Type: Application
    Filed: February 21, 2017
    Publication date: August 24, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Celine Casi, Jan Emiel Godelieve Vertommen
  • ACID RESISTANT CAPSULES
    Publication number: 20170231918
    Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 17, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Dominique Nicolas Cade, Xiongwei David He
  • CAPSULE FORMULATION
    Publication number: 20170216146
    Abstract: Technical Problem A problem of the present invention is, in one aspect, to provide a capsule formulation including an active ingredient and the like that may deteriorate upon contacting an acid, wherein the capsule formulation makes it possible not to deteriorate the active ingredient and the like by a gastric acid which enters into a capsule film. Technical Solution A capsule formulation comprising an active ingredient and oil, wherein said capsule of said formulation is an enteric capsule comprising a water soluble film forming polymer and gellan gum; said oil is an oil acceptable for pharmaceuticals or foods; and said active ingredient is encapsulated in said capsule together with said oil, and the production method thereof, are provided.
    Type: Application
    Filed: July 31, 2014
    Publication date: August 3, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Keith Hutchison, Takahisa Takubo
  • Acid resistant capsules
    Patent number: 9700517
    Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: July 11, 2017
    Assignee: Capsugel Belgium NV
    Inventors: Dominique Nicolas Cade, Xiongwei David He
  • Hydroxypropyl methyl cellulose hard capsules and process of manufacture
    Patent number: 9655860
    Abstract: A composition for manufacture of hard hydroxypropyl methyl cellulose capsules comprising a film forming material of hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), and a hydroxypropoxy content of 4.0-7.5% and as a 2% weight solution, a viscosity of 3.5-6.0 cPs at 20° C., dipping compositions, process for manufacture of hard hydroxypropyl methyl cellulose capsules according to a dip coating process and hard capsule shells.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: May 23, 2017
    Assignee: Capsugel Belgium NV
    Inventors: Dominique Nicolas Cade, David He Xiongwei
  • APPARATUS AND METHOD FOR ACQUIRING A TWO-DIMENSIONAL IMAGE OF THE SURFACE OF A THREE-DIMENSIONAL OBJECT
    Publication number: 20170131221
    Abstract: An apparatus for acquiring a two-dimensional image of an external surface of a three-dimensional object is described. The apparatus includes a conveyor for supporting and displacing the object, a camera for capturing images of portions of the object surface, and a friction member for rotating the object. The camera is configured to capture images corresponding to successive exposed portions of the object surface, and to sequentially capture the images as respective single frames. The apparatus further includes an electronic control unit adapted to read out a sub-frame from the single frame, store the sub-frame, and assemble successive sub-frames into an assembled frame corresponding to a two-dimensional image of a surface area of the object.
    Type: Application
    Filed: January 23, 2017
    Publication date: May 11, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Mark Robson Humphries, Paul Antony Merritt, Stefaan Jaak Vanquickenborne
  • ORALLY DISINTEGRATING TABLET CONTAINING SOLID LIPID PARTICLES AND METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20170112762
    Abstract: The instant disclosure provides embodiments of orally disintegrating tablet compositions that have rapid disintegrability in the oral cavity and comprise solid lipid particles enclosing at least one active ingredient to mask any unpleasant tastes associated with the active ingredient. Also provided is the process of preparing such orally disintegrating tablet pharmaceutical compositions.
    Type: Application
    Filed: May 14, 2015
    Publication date: April 27, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Aurélien Sivert, Cyrille Andrès, Hassan Benameur
  • STABLE DOSAGE FORM ARTICLES FOR ORAL ADMINISTRATION
    Publication number: 20170095426
    Abstract: A novel gelatin comprising dosage form article for oral administration and for containing therein a fill composition, the fill composition comprising one or more active materials capable of reacting with gelatin, and optionally one or more excipient materials, wherein the dosage form is made of a gelatin material and one or more plasticizers, the gelatin material having a mean molecular weight of less than about 130,000 g/mol and a low microgel content, wherein the fraction of microgel is of less than about 10% of the total number of gelatin chains of said gelatin material.
    Type: Application
    Filed: May 14, 2015
    Publication date: April 6, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Jan Emiel Godelieve Vertommen, Céline Casi, Annabel Igonin, Claire Geneviève Odile Tardy
  • HYDROXYPROPYL METHYL CELLULOSE HARD CAPSULES AND PROCESS OF MANUFACTURE
    Publication number: 20170087092
    Abstract: A composition for manufacture of hard hydroxypropyl methyl cellulose capsules comprising a film forming material of hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), and a hydroxypropoxy content of 4.0-7.5% and as a 2% weight solution, a viscosity of 3.5-6.0 cPs at 20° C., dipping compositions, process for manufacture of hard hydroxypropyl methyl cellulose capsules according to a dip coating process and hard capsule shells.
    Type: Application
    Filed: December 14, 2016
    Publication date: March 30, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Dominique Nicolas Cade, David He Xiongwei
  • Method for banding hard capsules using hydroxypropylmethyl cellulose (HPMC) as a base
    Patent number: 9579290
    Abstract: The present invention provides a banding composition for hard capsules using hydroxypropylmethyl cellulose (HPMC) as a base comprising (1) low viscosity HPMC; (2) a component selected from the group consisting of methanol, ethanol, isopropanol, 1-propanol, acetone and/or ethyl acetate; (3) a surfactant; and (4) water; and a method for banding hard capsules using hydroxypropylmethyl cellulose as a base by using the banding composition described.
    Type: Grant
    Filed: August 6, 2006
    Date of Patent: February 28, 2017
    Assignee: Capsugel Belgium NV
    Inventors: Xiongwei He, Dominique Cade
  • Apparatus and method for acquiring a two-dimensional image of the surface of a three-dimensional object
    Patent number: 9575011
    Abstract: An apparatus for acquiring a two-dimensional image of an external surface of a three-dimensional object is described. The apparatus includes a conveyor for supporting and displacing the object, a camera for capturing images of portions of the object surface, and a friction member for rotating the object. The camera is configured to capture images corresponding to successive exposed portions of the object surface, and to sequentially capture the images as respective single frames. The apparatus further includes an electronic control unit adapted to read out a sub-frame from the single frame, store the sub-frame, and assemble successive sub-frames into an assembled frame corresponding to a two-dimensional image of an unpeeled surface area of the object.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: February 21, 2017
    Assignee: Capsugel Belgium NV
    Inventors: Mark Robson Humphries, Paul Antony Merritt, Stefaan Jaak Vanquickenborne
  • ACID RESISTANT BANDING SOLUTION FOR ACID RESISTANT TWO PIECE HARD CAPSULES
    Publication number: 20170035699
    Abstract: The present disclosure relates to acid resistant banding solutions for two piece hard capsules endowed with acid resistant properties, and methods of making and using acid resistant banding solutions. The present disclosure also relates, in part, to methods for banding such acid resistant capsules which provides an acid resistant seal between the capsule parts and achieves increased acid resistance in vitro.
    Type: Application
    Filed: October 24, 2016
    Publication date: February 9, 2017
    Applicant: Capsugel Belgium NV
    Inventors: Xiongwei He, Dominique Nicolas Cade