Patents Assigned to Capsugel Belgium
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Patent number: 9575011Abstract: An apparatus for acquiring a two-dimensional image of an external surface of a three-dimensional object is described. The apparatus includes a conveyor for supporting and displacing the object, a camera for capturing images of portions of the object surface, and a friction member for rotating the object. The camera is configured to capture images corresponding to successive exposed portions of the object surface, and to sequentially capture the images as respective single frames. The apparatus further includes an electronic control unit adapted to read out a sub-frame from the single frame, store the sub-frame, and assemble successive sub-frames into an assembled frame corresponding to a two-dimensional image of an unpeeled surface area of the object.Type: GrantFiled: July 8, 2016Date of Patent: February 21, 2017Assignee: Capsugel Belgium NVInventors: Mark Robson Humphries, Paul Antony Merritt, Stefaan Jaak Vanquickenborne
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Publication number: 20170035699Abstract: The present disclosure relates to acid resistant banding solutions for two piece hard capsules endowed with acid resistant properties, and methods of making and using acid resistant banding solutions. The present disclosure also relates, in part, to methods for banding such acid resistant capsules which provides an acid resistant seal between the capsule parts and achieves increased acid resistance in vitro.Type: ApplicationFiled: October 24, 2016Publication date: February 9, 2017Applicant: Capsugel Belgium NVInventors: Xiongwei He, Dominique Nicolas Cade
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Patent number: 9561189Abstract: A dosage form article suitable for oral administration, comprising more than one compartments each delimited by a plurality of distinct segments selected from the group consisting of body parts, cap parts and combinations thereof. The dosage form article comprises: at least one first body part and at least one first cap part each comprising inner and outer surfaces, wherein the first body and cap parts are telescopically engageable; and at least one second body part, comprising inner and outer surfaces, being telescopically engageable with the at least one first body or cap parts or both. The at least one of the second body parts is arranged within the at least one first body part or cap part or both such that a distinct first compartment is formed between the outer surface of the second body part and the inner surface of the first body part or cap part or both.Type: GrantFiled: October 23, 2014Date of Patent: February 7, 2017Assignee: Capsugel Belgium NVInventors: Hilde Buydts, Stefaan Vanquickenborne
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Publication number: 20160320313Abstract: An apparatus for acquiring a two-dimensional image of an external surface of a three-dimensional object is described. The apparatus includes a conveyor for supporting and displacing the object, a camera for capturing images of portions of the object surface, and a friction member for rotating the object. The camera is configured to capture images corresponding to successive exposed portions of the object surface, and to sequentially capture the images as respective single frames. The apparatus further includes an electronic control unit adapted to read out a sub-frame from the single frame, store the sub-frame, and assemble successive sub-frames into an assembled frame corresponding to a two-dimensional image of an unpeeled surface area of the object.Type: ApplicationFiled: July 8, 2016Publication date: November 3, 2016Applicant: Capsugel Belgium NVInventors: Mark Robson Humphries, Paul Antony Merritt, Stefaan Jaak Vanquickenborne
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Publication number: 20160296475Abstract: The present disclosure relates to liquid filled hard capsules comprising hydroxypropyl methyl cellulose, pullulan, or mixtures thereof comprising a liquid fill of an effective amount of beta-hydroxy-beta-methylbutyric acid (HMB free acid) in liquid form and at least on excipient selected from quaternary ammonium salts, amino acids, amino acid derivatives, monosaccharides, disaccharides, and mixtures thereof.Type: ApplicationFiled: December 11, 2014Publication date: October 13, 2016Applicant: Capsugel Belgium NVInventor: Tyler Oswald White
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Publication number: 20160287522Abstract: A dosage form article suitable for oral administration, comprising more than one compartments each delimited by a plurality of distinct segments selected from the group consisting of body parts, cap parts and combinations thereof. The dosage form article comprises: at least one first body part and at least one first cap part each comprising inner and outer surfaces, wherein the first body and cap parts are telescopically engageable; and at least one second body part, comprising inner and outer surfaces, being telescopically engageable with the at least one first body or cap parts or both. The at least one of the second body parts is arranged within the at least one first body part or cap part or both such that a distinct first compartment is formed between the outer surface of the second body part and the inner surface of the first body part or cap part or both.Type: ApplicationFiled: October 23, 2014Publication date: October 6, 2016Applicant: Capsugel Belgium NVInventors: Hilde Buydts, Stefaan Vanquickenborne
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Patent number: 9456990Abstract: The invention provides a multi-compartmented container suitable for the delivery of pharmaceuticals, medicines, vitamins, and the like.Type: GrantFiled: January 22, 2015Date of Patent: October 4, 2016Assignee: Capsugel Belgium NVInventors: Clinton Wesley McInnes, Anna Marie Underwood, Phillip Andrew Vickery
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Publication number: 20160256384Abstract: A dosage form article suitable for oral administration may include more than one compartment, each formed by a plurality of distinct segments of the dosage form article. The dosage form article may also include a signaling means and a drug, wherein the signaling means and the drug are each stored in different compartments physically separated from one another. Both the drug and the signaling means may be wholly incorporated within the dosage form article, the respective compartments being arranged to fully enclose the drug and signaling means only when at least two of the plurality of distinct segments are connected.Type: ApplicationFiled: December 3, 2014Publication date: September 8, 2016Applicant: Capsugel Belgium NVInventors: Hilde Buydts, Stefaan Jaak Vanquickenborne
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Publication number: 20160256399Abstract: The present disclosure relates to delivery systems and methods for increasing the bioavailability and increasing the absorption rate by monolithic enteric capsule administration to humans of active ingredients compared to the bioavailability of active ingredients enterically coated for modified release or gastric protection, particularly acid sensitive active ingredients such as esomeprazole, omeprazole, and other proton pump inhibitors, systems for delivering active pharmaceutical ingredients to humans or animals via monolithic enteric capsules, and improved methods of treating gastrointestinal disorders with such methods and delivery systems.Type: ApplicationFiled: October 24, 2014Publication date: September 8, 2016Applicant: Capsugel Belgium NVInventors: Chang Q. Lee, Hassan Benameur
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Patent number: 9414027Abstract: An apparatus for acquiring a two-dimensional image of an external surface of a three-dimensional object is described. The apparatus includes a conveyor for supporting and displacing the object, a camera for capturing images of portions of the object surface, and a friction member for rotating the object. The camera is configured to capture images corresponding to successive exposed portions of the object surface, and to sequentially capture the images as respective single frames. The apparatus further includes electronic control unit adapted to read out a sub-frame from the single frame, store said sub-frame, and assemble successive sub-frames into an assembled frame corresponding to a two-dimensional image of an unpeeled surface area of the object.Type: GrantFiled: October 5, 2011Date of Patent: August 9, 2016Assignee: Capsugel Belgium NVInventors: Mark Robson Humphries, Paul Antony Merritt, Stefaan Jaak Vanquickenborne
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Patent number: 9333177Abstract: The present invention relates to a novel liquid delivery carrier comprising a specific grade of glyceryl caprylate and PEG-40 hydrogenated castor oil in particular amounts. This carrier can be loaded with slightly or poorly water soluble substances and filled into hard gelatin capsule shells for final administration to a subject. Also disclosed are filling compositions comprising such delivery carrier and hard gelatin capsules filled with the carrier and the composition of the invention. The delivery carrier of the invention proved to be compatible with both the hard gelatin capsule shells and the substances loaded into it.Type: GrantFiled: October 26, 2010Date of Patent: May 10, 2016Assignee: Capsugel Belgium NVInventors: David Delmarre, Marie-Sophie Lina Martina, Jan Emiel Godelieve Vertommen
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Publication number: 20160022593Abstract: The present disclosure relates to a separable hard capsule for containing a medication. The capsule may be opened by finger force and used, for example, by pediatric and geriatric patients.Type: ApplicationFiled: February 13, 2014Publication date: January 28, 2016Applicant: CAPSUGEL BELGIUM NVInventors: Hilde Buydts, Stefaan Jaak Vanquickenborne
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Publication number: 20160015651Abstract: A problem of the present disclosure is, in one embodiment, to create a hard capsule formulation that includes a pharmaceutical agent or the like whose components deteriorate upon contact with an acid, in which the pharmaceutical agent or the like does not deteriorate due to gastric acid penetrating into the outer shell of the hard capsule. A hard capsule formulation comprising a hard capsule with acid resistance, in which the hard capsule is not treated with enteric coating, and the hard capsule formulation comprises an agent to inhibit invasion of gastric fluid and a pharmaceutical agent in the hard capsule.Type: ApplicationFiled: March 3, 2014Publication date: January 21, 2016Applicant: Capsugel Belgium NVInventor: Takahisa Takubo
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Publication number: 20160015647Abstract: The present disclosure relates to a new, stable, oil based liquid suspension filled hard capsule dosage form for bismuth salts such as bismuth subsalicylate, a process for its manufacture, methods to deliver bismuth salts to humans or animals via stable hard capsules, and improved methods of treating gastrointestinal disorders with such dosage forms.Type: ApplicationFiled: March 3, 2014Publication date: January 21, 2016Applicant: CAPSUGEL BELGIUM NVInventors: Eric Ehrnsperger, Christopher Diorio, Joseph J. Gross, John Lokhnauth
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Publication number: 20160000714Abstract: Solid lipid particles comprising a lipid hydrophobic matrix and from about 5 wt. % to about 30 wt. % of curcumin, and methods of making and treatment thereof.Type: ApplicationFiled: March 4, 2014Publication date: January 7, 2016Applicant: Capsugel Belgium NVInventors: Christopher Diorio, John Lokhnauth
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Patent number: 9211659Abstract: A method and apparatus for forming hard shell capsule components, wherein the capsule components are formed from a material which undergoes gelation upon heating, such as HPMC. A heat station is provided to heat a plurality of molds prior to dipping into a solution of the thermogeling material. The drying conditions following dipping are carefully controlled to control the rate of drying.Type: GrantFiled: December 4, 2013Date of Patent: December 15, 2015Assignee: Capsugel Belgium NVInventors: Jan Juilen Irma De Bock, Jan Donaat Sinnaeve, Stefaan Jaak Vanquickenborne
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Publication number: 20150342892Abstract: The present disclosure relates to a novel aqueous coating composition comprising a polymer, at least one glidant, and at least one emulsifier, and at least one plasticizer, for soft capsule shells or softgel capsules, providing an enteric release profile, and to a method of enteric coating of soft capsule shells or containers; and to the resulting enteric coated soft capsule shells or softgel capsules with the aqueous coating composition.Type: ApplicationFiled: March 3, 2014Publication date: December 3, 2015Applicant: Capsugel Belgium NVInventors: Jan Vertommen, Marie Sophie Martina
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Patent number: 9198868Abstract: The present disclosure relates to aqueous compositions for use in the manufacture of capsule shells endowed with bulk enteric properties. The present disclosure also relates, in part, to aqueous dispersions suitable for the implementation of said manufacturing process, and to enteric capsule shells and hard capsules obtained therewith.Type: GrantFiled: October 24, 2011Date of Patent: December 1, 2015Assignee: Capsugel Belgium NVInventors: Hassan Benameur, Dominique Nicolas Cade, Sophie Schreiber
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Patent number: 9138920Abstract: A method and apparatus for forming hard shell capsule components, wherein the capsule components are formed from a material which undergoes gelation upon heating, such as HPMC. A heat station is provided to heat a plurality of molds prior to dipping into a solution of the thermogeling material. The drying conditions following dipping are carefully controlled to control the rate of drying.Type: GrantFiled: October 17, 2007Date of Patent: September 22, 2015Assignee: Capsugel Belgium NVInventors: Jan Juilen Irma De Bock, Jan Donaat Sinnaeve, Stefaan Jaak Vanquickenborne
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Publication number: 20150140084Abstract: The present disclosure relates to acid resistant banding solutions for two piece hard capsules, and methods of making the same. The present disclosure also relates, in part, to a method for banding such capsules which provides an acid resistant seal between the capsule parts and achieves an increased acid resistance in vitro. The instant disclosure further relates to a capsule sealing solution formula that comprises shellac ink or shellac ink vehicle component.Type: ApplicationFiled: May 20, 2013Publication date: May 21, 2015Applicant: Capsugel Belgium NVInventor: Takahisa Takubo