Abstract: A method for the manufacture of core-membrane capsules, which manufacturing method includes: (i) a step of providing two immiscible solutions, namely: a first solution containing at least one first reactive molecule including at least two azlactone groups, and a second solution containing at least one second reactive molecule including at least two amine groups, and (ii) an interfacial polymerization step during which the immiscible solutions are mixed so that the reactive molecules react together by an interfacial polymerization reaction, on the surface of the droplets, to form the membrane including a polyamide polymer.

Abstract: A granule comprising: sodium butyrate particles, a fatty material matrix comprising fatty acids encapsulating the sodium butyrate particles, the granule preserving its morphology following gastric and enteric digestion simulation in vitro tests, the granule featuring a gastric resistance conferring protection on the sodium butyrate particles in the stomach, and featuring a sustained release of the sodium butyrate particles in the intestinal tract.