Abstract: A method for creating alarm signals based on time-series signal behavior determined from real-time discrete data obtained from a medical device. In one embodiment the method includes identifying patterns in preceding time-series measurement threshold breaches in clinical readings obtained from said medical device when associated with a particular patient, and initiating an alarm signal to a front-line clinician based on the preceding quantity of threshold breaches.

Abstract: Disclosed are devices and methods for detecting activation of an electronic device, including a biomedical and biometric device. The electronic device can operate in a low-power mode until it is determined that the electronic device is in close proximity to or in contact with a body, and activated. The electronic device can include a first sensor including a first capacitance sensor, a second sensor, and a controller coupled to the first sensor and the second sensor. The controller can receive a first signal from the first sensor and determine that the electronic device is in close proximity to or in contact with a body based on the first signal, and receive a second signal from the second sensor and determine that the electronic device is activated based on one or both of the first signal and the second signal. The electronic device can transition from the low-power mode to an active mode in response to determining that the electronic device is activated.

Abstract: A membrane-forming composition, soft and hard capsules prepared based on the composition and the preparation methods are described. The membrane-forming composition includes pullulan polysaccharide, gellan gum, amino acid moisturizing agent, anti-hygroscopic agent and so on. It is suitable for the fabrication of hard or soft capsules. The membrane-forming composition can gelate without alkali metal ions. It has a high moisture retention rate which makes it not easy to take up moisture and turn soft in high humid environment, and it will not turn yellow during long time storage. Furthermore, the membrane-forming composition is made up of pure natural materials.

Abstract: The packaging system according to the invention comprises a container (1), which includes a neck (2) defining an axis (X-X), and a stopper (10) for closing the neck, which includes a skirt (12) adapted to be fastened removably around the neck.

Abstract: Techniques provided herein are directed toward accurately determining when an item is removed from a blister pack by utilizing capacitive sensors. The capacitive sensors may be positioned on each blister of the blister and may detect the presence of the skin of the finger and/or the whether the blister has been deformed, which can occur when an item is removed from the blister. Some embodiments may determine whether skin was detected at the time of extraction to determine whether extraction was intentional.

Abstract: Systems and methods select accelerometer data to store on computer-readable media. Systems may comprise an accelerometer, a processor, and a computer-readable medium storing instructions executed by the processor. Accelerometer data from a critical time period are stored on a computer readable medium if an activity ratio for the critical time period exceeds an activity threshold. The numerator of the activity ratio comprises a count of data windows in the critical time period that satisfy one or more count criteria and the denominator comprises the total number of data windows in the critical time period.

Abstract: Systems, methods, and devices of the various embodiments provide a pulse oximeter capable of taking blood oxygen readings based on readings from an accelerometer. The various embodiments may provide an electronic patch including a pulse oximeter and accelerometer connected to a processor, wherein the processor is configured with processor executable instructions to control the operation of the pulse oximeter based at least in part on data received from the accelerometer. In various embodiments the electronic patch may further include a coin cell battery, or other low power source, that may power the pulse oximeter.

Abstract: Generally described, aspects of the disclosed subject matter are directed to a cork wiring device for closure of a stopper of a bottle of champagne or other effervescent drink. The cork wiring device generally includes an assembly made of metal wire and provided with two parts, namely on the one hand a cage having three legs, and on the other hand a band joined to a free end of each of said legs. The cork wiring device may also include a plate associated with the cage to constitute an interface, the three legs meeting at their end opposite to their free end, forming a loop, and the plate may include three exclusively lateral grooves, each of said lateral grooves being associated with one of said legs and intended to receive a portion of the associated leg located between the free end and the loop.

Abstract: A membrane-forming composition, soft and hard capsules prepared based on the composition and the preparation methods are described. The membrane-forming composition includes pullulan polysaccharide, gellan gum, amino acid moisturizing agent, anti-hygroscopic agent and so on. It is suitable for the fabrication of hard or soft capsules. The membrane-forming composition can gelate without alkali metal ions. It has a high moisture retention rate which makes it not easy to take up moisture and turn soft in high humid environment, and it will not turn yellow during long time storage. Furthermore, the membrane-forming composition is made up of pure natural materials.

Abstract: A robotic capsule filling machine system is disclosed. In particular, the system may include a robotic capsule filling machine that is controlled by a computing device, such as a tablet. An application executing on the computing device may be utilized by a user to create a capsule formulation to be dispensed in capsules to be filled by the robotic capsule filling machine. Various inputs into the application may include, but are not limited to, a capsule size, a purity, a density, and a batch size. Based on the inputs, the system may translate the inputs to determine the desired capsule formulation. If the capsule formulation is valid, the system may cause the robotic capsule filling machine to extract an amount of the capsule formulation from one or more reservoirs. The robotic capsule filling machine may then proceed to dispense the extracted amount of capsule formulation into a plurality of capsules.

Abstract: An object is to provide a method of manufacturing a soft capsule that is enteric and excellent in formulation properties. An enteric soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxyl pectin having a degree of amidation of 5 to 25%, and (b) encapsulating capsule fills using the enteric capsule shell liquid prepared in the step (a) by stamping. Preferably, the jelly strength of the gelatin is 160 to 300 Bloom, the degree of esterification of the low methoxy pectin is 20 to 40%, and the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin.

Abstract: Provided are a plant-derived soft capsule shell having a high shell sheet strength, a good adhesive property, and excellent shell performance, and a soft capsule. The soft capsule shell comprises: (A) iota carrageenan; and (B) a starch dispersion obtained by ultrasonically treating a starch paste solution.

Abstract: An object is to provide a method of manufacturing a seamless soft capsule that is enteric and excellent in formulation properties. An enteric seamless soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of esterification of 0 to 40% and a degree of amidation of 0 to 25%, the enteric capsule shell liquid having a viscosity at 50° C. of 60 to 127 mPa·s; and (b) encapsulating capsule fills with the enteric capsule shell liquid prepared in the step (a) by dripping. Preferably, the jelly strength of the gelatin is 180 to 330 Bloom, an aqueous solution of the low methoxy pectin at a concentration of 2 mass % has a viscosity at 35° C. of 8 to 15 mPa·s, and the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of gelatin.

Abstract: Provided are a plant-derived soft capsule shell having high shell sheet strength, good adhesive property, and good shell performance, and a soft capsule. A soft capsule shell comprising: (A) iota carrageenan; and (B) waxy corn starch having undergone a heat-moisture treatment in the presence of a salt, the soft capsule shell having a content mass ratio [(A)/(B)] of the component (A) to the component (B) of 0.4 to 3, the soft capsule shell having a content mass ratio [carrageenan/starch] of carrageenan including the component (A) to starch including the component (B) of 0.29 to 1.

Abstract: The present invention provides an acid resistant capsule shell composition comprising a water-soluble enteric polymer, a water-soluble film forming polymer, a coagulant, and a gelling aid. The water-soluble enteric polymer comprises hydrophobic functional groups and hydrophilic functional groups. The present invention further provides a process for preparing an acid resistant capsule shell comprising: dissolving said acid resistant capsule shell composition in deionized water to form a capsule shell solution; heating and then cooling the capsule shell solution to form a capsule shell stock solution; dipping a pin into the capsule shell stock solution and then removing the pin to form a film-coated pin; and drying the film-coated pin to form the acid resistant capsule shell. The acid resistant capsule shell has acidic resistance and the process for preparing the acid resistant capsule shell involves no organic solvent; hence, the problem of organic solvent residues can be prevented.

Abstract: The invention relates to a method and a system for collecting medical data produced by medical devices (1) situated, for example, in intensive care units and for disseminating said information to the health professionals using computer equipment (5). The process and the system include the following software modules: (I) one service module (DS) (21), (II) a data storage module (DDS) (25), (III) control modules (DAC) (26) accessible from any point of said computer communications network and controlling the distribution of said data D, (IV) a device interface module (DDI) (23), configured as a function of the specifications of said transmitter devices (1), (V) a communications interface module (DCI) (22), (VI) a configuration interface module (DCP) (28), (VII) a data portal module (DDP).

Abstract: Provided are a plant-derived soft capsule shell having a high shell sheet strength, a good adhesive property, and excellent shell performance, and a soft capsule. The soft capsule shell comprises: (A) iota carrageenan; and (B) a starch dispersion obtained by ultrasonically treating a starch paste solution.

Abstract: Composite cap intended to be snapped on the glass ring of a bottle and then to serve as a stopper that can screwed and unscrewed as required, the glass ring being provided with at least one annular bead. It comprises a shell with a skirt provided with an internal annular bead; a first insert, disposed inside said shell, provided with an internal screw thread, characterized in that it also comprises a second insert having at least two roughly cylindrical portions; the first portion being provided on its external wall with a screw thread complementary to that of said first insert, the second portion being provided with axial immobilization means intended to cooperate with said annular bead and axial stop means, cooperating with said internal annular bead, so that the inserts secured together by screwing are trapped inside said shell.

Abstract: A method of manufacturing a capsule 12 for holding a substance 14 includes providing a capsule body 2 having a closed end 5 and an opposed open end 6; providing a diaphragm 4 having a closed end 7 and an opposed open end 8; partially filling the body 2 with substance 14; providing a gas-tight chamber; providing a nitrogen gas environment within the chamber; applying a partial vacuum to the chamber; supporting an outer side 43 of the body 2; supporting an inner side 102 of the diaphragm 4; while supporting the body 2 and the diaphragm 4, inserting the closed end 7 of the diaphragm 4 into the open end 6 of the body 2 until regions of the body 2 and the diaphragm 4 overlap one another, thereby closing off the open end 6 of the body 2 and forming a chamber 104 within which the substance 14 is held; and heat welding the overlapping regions of the capsule body 2 and the diaphragm 4 to one another to hermetically seal the chamber 104.