Abstract: The present invention relates to sphingolipids, a method for the production of sphingoid bases, especially sphingosine, and novel derivatives thereof. The sphingoid bases are herein produced by making use of a vinylogous amide-type protecting group. The resulting vinylogous amide compounds enable an easy and effective production of sphingoid bases, especially sphingosine.

Abstract: The present invention relates to a topical composition comprising one or more compounds of formula (I), wherein X is hydrogen or a glycosyl moiety, the carbon-carbon bond noted is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted is a double or a single bond, and R3 is —OH when the carbon-carbon bond noted is a single bond, R4 is hydrogen when the carbon-carbon bond noted is a double or a single bond, and R4 is hydrogen or —OH when the carbon-carbon bond noted is a double bond, said composition is characterized in that at least one of the one or more compounds of formula (I) has a lactosyl moiety or a glucosyl moiety in the position X.

Abstract: The present invention relates to several novel 1-O-glycosylated sphingoid bases and to a production method thereof, as well as to uses of the 1-O-glycosylated sphingoid bases. Sphingoid bases carrying a vinylogous amide-type protecting group are used herein for the production of 1-O-glycosylated sphingoid bases. These vinylogous amide compounds enable an easy and effective production of 1-O-glycosylated sphingoid bases.