Abstract: The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to ameliorate mitochondrial toxicity caused by administration of a chemical, food, or drug.
Type:
Grant
Filed:
June 5, 2012
Date of Patent:
August 21, 2018
Assignee:
Cardero Therapeutics, Inc.
Inventors:
Francisco Villarreal, Alan Maisel, George Schreiner, Guillermo M. Ceballos Reyes, Pam Taub
Abstract: The present invention relates to compounds and compositions and their applications as pharmaceuticals for treating, preventing, or reversing injury to skeletal or cardiac muscles, for treating or preventing diseases relating to the structure and function of skeletal or cardiac muscle, and for inducing regeneration or restructuring of skeletal or cardiac muscle as a means of treating diseases relating to abnormalities in skeletal or cardiac muscle structure and function in a human or animal subject. Further aspects relate to the same or similar applications for bone and bone diseases.
Type:
Application
Filed:
February 20, 2018
Publication date:
July 12, 2018
Applicant:
Cardero Therapeutics, Inc.
Inventors:
George F. SCHREINER, Guillermo CEBALLOS, Sundeep DUGAR
Abstract: The present invention relates to compounds and compositions and their application as pharmaceuticals for treating, preventing, or reversing injury to skeletal or cardiac muscles, for treating or preventing diseases relating to the structure and function of skeletal or cardiac muscle, and for inducing regeneration or restructuring of skeletal or cardiac muscle as a means of treating diseases relating to abnormalities in skeletal or cardiac muscle structure and function in a human or animal subject.
Type:
Grant
Filed:
March 22, 2013
Date of Patent:
February 27, 2018
Assignee:
CARDERO THERAPEUTICS, INC.
Inventors:
George F. Schreiner, Guillermo Ceballos, Sundeep Dugar
Abstract: The present invention relates to compounds, compositions, and methods for treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more epicatechin derivatives in an amount effective to stimulate mitochondrial function in cells. The compounds, compositions, and methods described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.
Type:
Grant
Filed:
August 6, 2012
Date of Patent:
November 17, 2015
Assignee:
CARDERO THERAPEUTICS, INC.
Inventors:
Cyrus K. Becker, George F. Schreiner, Sundeep Dugar, Dinesh Mahajan
Abstract: The present invention relates to compounds, compositions, and methods for treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more epicatechin derivatives in an amount effective to stimulate mitochondrial function in cells. The compounds, compositions, and methods described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.
Type:
Application
Filed:
August 6, 2012
Publication date:
September 11, 2014
Applicant:
Cardero Therapeutics, Inc.
Inventors:
Cyrus K. Becker, George F. Schreiner, Sundeep Dugar, Dinesh Mahajan