Abstract: The disclosure relates to a pressurized Metered Dose Inhaler-compatible tablet, i.e. one that is able to be dispersed or disintegrates within a liquid phase propellant, which is used in a pressurized Metered Dose Inhaler formulation containing at least one active pharmaceutical ingredient and one or more excipients.
Abstract: The invention relates to a method for the manufacture of a pressurized Metered Dose Inhaler (pMDI) and components for use in said method, in particular, a pMDI compatible tablet (i.e. one that is able to be dispersed or disintegrates within a liquid phase, such as a propellant, used in a pMDI formulation) which contains at least one active pharmaceutical ingredient (API) and, optionally, one or more excipients.
Abstract: An aerosol composition comprising a propellant and a first particulate material comprising particle having a median aerodynamic diameter within the range 0.05 to 11 &mgr;m, such as a medicament suitable for pulmonary inhalation, and a second particulate material comprising particles having a median volume diameter within the range 15 to 200 &mgr;m. The presence of the second particulate material provides good suspension properties, particularly where the propellant is a hydrofluoro alkane.
Type:
Grant
Filed:
January 30, 2001
Date of Patent:
May 18, 2004
Assignees:
University College Cardiff Consultants Limited, Cardiff Scintigraphics Limited
Inventors:
Paul Alfred Dickinson, Simon John Warren