Abstract: The present invention includes an apparatus and a method for testing exhaled breath condensate for at least one biometric marker, including a substrate for collecting exhaled breath condensate, the substrate capable of being brought to a temperature below a dew point of vapor in exhaled breath, a collector for retaining the substrate and for receiving a biometric marker reagent. The invention may further include receiving exhaled breath in a collector, the collector comprising a substrate, the substrate being at a temperature below a dew point of vapor in exhaled breath, collecting the exhaled breath condensate on the substrate, and bringing a biometric marker reagent in contact with the substrate.

Abstract: The present invention advantageously provides a system for automatically delivering oxygen to a patient, including a sensor to measure an amount of oxygen in a bloodstream of a patient, a pneumatics subsystem and a control subsystem. The pneumatics subsystem includes an oxygen inlet, an air inlet, a gas mixture outlet, and a gas delivery mechanism to blend the oxygen and air to form a gas mixture having a delivered oxygen concentration, and to deliver the gas mixture to the patient. The control subsystem includes an input device to receive a desired concentration of oxygen in the bloodstream of the patient, a sensor interface to receive measurement data and status information associated with the measurement data from the sensor, a pneumatics subsystem interface to send commands to, and receive data from, the pneumatics subsystem, and a processor to control the delivered oxygen concentration based on the desired oxygen concentration, the measurement data and the status information.

Abstract: The present invention advantageously provides a method of automatically delivering oxygen to a patient. A desired concentration of oxygen in a bloodstream of a patient is received from a user. Data, including a measurement of the amount of oxygen in the bloodstream of the patient, as well as status information associated with the measurement, is received from a sensor. The measured data are determined to be valid or invalid based on the measurement value and the status information, and, based on this determination, a delivered fraction of inspired oxygen is delivered to the patient. If the measured data are determined to be valid, then the delivered fraction of inspired oxygen is based on the desired oxygen concentration and the measured data. On the other hand, if the measured data are determined to be invalid, then the delivered fraction of inspired oxygen is set to a predetermined value.

Abstract: A gas flow regulating device including a housing assembly, an inlet tube assembly, and a biasing device. The housing assembly has a main housing, a valve seat body, and a distal plate forming an outlet orifice. The inlet tube assembly includes a proximal inlet end, a tube forming a lumen, and a flange, and is slidably disposed within the main housing, biased to an open state by the biasing device. The flange separates middle and constant pressure chambers within the housing assembly. The inlet tube assembly is transitionable to a closed state in response to pressure in the constant pressure chamber to generate a relatively constant flow rate of air exiting the device via the outlet orifice.

Abstract: A device and method is disclosed for delivering NO to a patient. The device utilizes a single controller that controls two separate flow controllers to deliver an oxygen-containing gas and a NO-containing gas to the patient to provide NO-containing gas at a flow profile that is proportional or quasi-proportional to a flow profile of the oxygen-containing gas throughout patient inspiration. The controller further comprises logic for setting a nitric oxide delivery profile comprising at least two different concentrations of nitric oxide containing gas and for automatically switching between the at least two different concentrations of nitric oxide containing gas on a timed basis.

Abstract: The present invention is directed to the administration of aerosolized particles to specific area of the lungs, and in particular to the targeted delivery of aerosolized pharmaceutical formulations to a specific area of the lungs. More specifically, the present invention relates to devices and methods for depositing aerosolized particles to a specific area of the lungs by regulating aerosolizing parameters of the device. The present invention also relates to devices, systems and methods for disease management, where the aerosolizing parameters are adjusted based on monitoring at least one health parameter.

Abstract: The present invention relates to compositions and methods for treatment of blood and blood products using gaseous nitric oxide. The treatment involves the contacting blood or a blood product with gaseous nitric oxide.