Abstract: The present invention is related to a pharmaceutical composition comprising cells committed to the generation of heart tissue and at least one pharmaceutically acceptable excipient produced according to internationally recognized standards for pharmaceutical product manufacture, a process for the manufacture of such a pharmaceutical composition and a kit for the administration of said pharmaceutical composition which comprises a container containing said pharmaceutical composition.
Type:
Grant
Filed:
May 20, 2010
Date of Patent:
September 20, 2016
Assignee:
CARDIO3 BIOSCIENCES S.A.
Inventors:
Vinciane Gaussin, Roland Gordon-Beresford, Christian Homsy
Abstract: The invention relates to an injection catheter for delivering a therapeutic agent into a substrate, comprising one or more lumens and a curved delivery element, said lumen serving as a guide for said curved delivery element outside of the substrate; said curved delivery element comprising openings on its distal tip, said distal tip comprising a distal zone and a proximal zone, said injection catheter being characterized in that the specific surface in said distal zone of said distal tip of said curved delivery element is higher than the specific surface in said proximal zone of said distal tip of said curved delivery element. The invention also relates to a process for delivering a therapeutic agent into a substrate.
Type:
Grant
Filed:
April 29, 2010
Date of Patent:
May 24, 2016
Assignee:
Cardio3 Biosciences
Inventors:
Jean-Pierre Latere Dwan'isa, Christian Homsy, Jozef Bartunek, Roland Gordon-Beresford
Abstract: The present invention is related to a pharmaceutical composition comprising cells committed to the generation of heart tissue and at least one pharmaceutically acceptable excipient produced according to internationally recognized standards for pharmaceutical product manufacture, a process for the manufacture of such a pharmaceutical composition and a kit for the administration of said pharmaceutical composition which comprises a container containing said pharmaceutical composition.
Type:
Application
Filed:
May 20, 2010
Publication date:
May 24, 2012
Applicant:
CARDIO3 BIOSCIENCES S.A.
Inventors:
Vinciane Gaussin, Roland Gordon-Beresford, Christian Homsy
Abstract: This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation.
Type:
Application
Filed:
May 20, 2010
Publication date:
April 26, 2012
Applicants:
CARDIO3 BIOSCIENCES SA, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors:
Andre Terzic, Atta Behfar, Roland Gordon-Beresford, Vinciane Gaussin, Christian Homsy
Abstract: The invention relates to an injection catheter for delivering a therapeutic agent into a substrate, comprising one or more lumens and a curved delivery element, said lumen serving as a guide for said curved delivery element outside of the substrate; said curved delivery element comprising openings on its distal tip, said distal tip comprising a distal zone and a proximal zone, said injection catheter being characterized in that the specific surface in said distal zone of said distal tip of said curved delivery element is higher than the specific surface in said proximal zone of said distal tip of said curved delivery element. The invention also relates to a process for delivering a therapeutic agent into a substrate.
Type:
Application
Filed:
April 29, 2010
Publication date:
March 29, 2012
Applicant:
CARDIO3 BIOSCIENCES
Inventors:
Jean-Pierre Latere Dwan'isa, Christian Homsy, Jozef Bartunek, Roland Gordon-Beresford