Abstract: A method for providing an in-vivo assessment of relative movement of an implant that is positioned in a living being is provided wherein a first assembly and a second assembly are positioned within the living being. The first assembly includes a passive electrical resonant circuit that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and, in response to the electromagnetic coupling, generates an output signal characterized by a frequency that is dependent upon a distance between the first assembly and the second assembly at the time of the electromagnetic coupling.

Abstract: A system and method for treating congestive heart failure in a patient, including: implanting at least one pressure sensor in a desired location within the patient; providing an ex-vivo interrogation system and monitoring system that can be configured to optionally affect at least one of: selectively energizing the at one pressure sensor, receiving a return or output signal from the at one pressure sensor, processing the return signal, and displaying processed data derived from the at least one pressure sensor to a physician. The system and method also includes deriving diagnostic and treatment information from the processed data and sending diagnostic and treatment information to the patient.

Abstract: A ventricular shunt systems and methods of preventing hydrocephalus are described herein. In one aspect, the ventricular shunt system has at least one pressure sensor that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and is variable in response to the pressure in a patient's ventricle.

Abstract: Provided herein are methods and systems for the treatment of cardiovascular conditions, including pulmonary hypertension (PH), in subjects that are being treated with a treatment regimen that includes a phosphodiesterase-5 (PDE-5) inhibitor.

Abstract: A method for monitoring data in a clinical environment comprises receiving information indicative of a number of ambulatory sensing systems in a measurement environment comprising a plurality of ambulatory sensing systems. The method also comprises establishing a communication scheme associated with the measurement environment based on the number of ambulatory sensing systems in the measurement environment. The method further comprises providing, to each ambulatory sensing system, information indicative of the established communication scheme. The method also comprises configuring, in a central data module associated with the measurement environment, parameters for communicating with each respective ambulatory sensing system in accordance with the established control scheme.

Abstract: Provided herein are devices, systems, and methods for assessing, treating, and for developing new treatments for pulmonary arterial hypertension (PAH) using pulmonary artery pressure (PAP) values and/or cardiac output (CO) estimates.

Abstract: The present disclosure is directed to a system having a database operable to receive at least one physiological parameter data from at least one of an electronic medical record (EMR) portal configured for receiving EMR data from an electronic medical record; a healthcare provider (HCP) portal configured for receiving HCP data; a patient portal configured for receiving patient data; and a medical device portal configured for receiving medical device data; for calculating secondary parameters from scoring algorithms, trend algorithms, parameter algorithms and treatment algorithms; then displaying the data and secondary parameters in a graphical format in order to for detect, diagnose and treat chronic disease in patients.

Abstract: This application relates to an apparatus and system for sensing strain on a portion of an implant positioned in a living being. In one aspect, the apparatus has at least one sensor assembly that can be mountable thereon a portion of the implant and that has a passive electrical resonant circuit that can be configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy. Each sensor assembly, in response to the electromagnetic coupling, can be configured to generate an output signal characterized by a frequency that is dependent upon urged movement of a portion of the passive electrical resonant circuit and is indicative of strain applied thereon a portion of the respective sensor assembly.

Abstract: A wireless sensor having a primary passive electrical resonant circuit that has an intrinsic electrical property that is variable in response to a characteristic of a patient and a secondary passive electrical resonant circuit. In one aspect, the primary passive resonant circuit can be positioned into a tuned position in response to the actuation of the secondary passive electrical resonant circuit. In a further aspect, in the tuned position, the primary passive electrical resonant circuit, in response to an energizing signal produced by an ex-vivo source of RF energy, is configured to generate a sensor signal characterized by a resonant frequency that is indicative of the characteristic.

Abstract: Aspects and embodiments of the present invention provide a system for obtaining, processing and managing data from an implanted sensor. In some embodiments, a patient or other persons can use a flexible antenna to obtain data from the implanted sensor. The flexible antenna includes at least one transmit loop and at least one receive loop. The transmit loop is adapted to propagate energizing signals to the implanted sensor. The receive loop is adapted to detect a response signal from the implanted sensor. The transmit loop includes a capacitor formed by a discontinuous area. The capacitor is adapted to allow the loop to be tuned. The flexible antenna can communicate with a patient device that collects the data from the implanted sensor, creates a data file and transmits the data file to a remote server over a network. A physician or other authorized person may access the remote server using an access device.

Abstract: Provided herein are methods for assessing, treating, and for developing new treatments for COPD. Methods can involve obtaining one or more PA hemodynamic readings from a subject with COPD, processing the PA hemodynamic readings to obtain one or more PA hemodynamic parameters, and using the one or more PA hemodynamic parameters to assess, treat, and/or develop new treatments for COPD. The methods can optionally be used to evaluate the progress of (COPD) in a subject, or to predict an outcome in a subject having COPD.

Abstract: Disclosed are hypertension systems and related methods that include a blood pressure sensor located or implanted under the skin of a patient, and electronics, which may have the size and shape of a wrist watch, for example, that monitors the blood pressure of the patient by communicating with the implanted sensor.

Abstract: An implant assembly is implanted in vivo within a vascular system in the implant assembly has a diameter greater than a vessel and compliance characteristics such that, upon release, the implant assembly forms an interference fit is between the anchor structure and the vessel wall, thereby preventing further distal movement.

Abstract: A delivery system for fixation of an implant assembly having an intracorporeal device at a deployment site using an anchoring structure. This invention provides an implant assembly having an anchor for fixation within a vessel. The anchoring structure adapted to be delivered via a catheter.

Abstract: This application relates to an apparatus and system for sensing strain on a portion of an implant positioned in a living being. In one aspect, the apparatus has at least one sensor assembly that can be mountable thereon a portion of the implant and that has a passive electrical resonant circuit that can be configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy. Each sensor assembly, in response to the electromagnetic coupling, can be configured to generate an output signal characterized by a frequency that is dependent upon urged movement of a portion of the passive electrical resonant circuit and is indicative of strain applied thereon a portion of the respective sensor assembly.

Abstract: Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

Abstract: The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

Abstract: Aspects and embodiments of the present invention provide a system for obtaining, processing and managing data from an implanted sensor. In some embodiments, a patient or other persons can use a flexible antenna to obtain data from the implanted sensor. The flexible antenna includes at least one transmit loop and at least one receive loop. The transmit loop is adapted to propagate energizing signals to the implanted sensor. The receive loop is adapted to detect a response signal from the implanted sensor. The transmit loop includes a capacitor formed by a discontinuous area. The capacitor is adapted to allow the loop to be tuned. The flexible antenna can communicate with a patient device that collects the data from the implanted sensor, creates a data file and transmits the data file to a remote server over a network. A physician or other authorized person may access the remote server using an access device.

Abstract: A communication system for communicating with an implanted wireless sensor is provided. A transmit antenna element can propagate an energizing signal onto a communication medium and a receive antenna element can recover a responsive implanted sensor response signal. The antenna box includes a power amplifier for amplifying the energizing signal and timing regeneration circuitry for detecting an end to signals and outputting control signals for selecting mode operation. The antenna box can receive the energizing signal from the antenna cable in a transmit mode and provide the implanted sensor response signal to the antenna cable in a receive mode. The antenna box can communicate with an electronic box and/or conversion box that provide and receive signals and provide power via the antenna cable.

Abstract: An implant assembly is implanted in vivo within a vascular system in which a vessel divides at a furcation into two sub-vessels, each sub-vessel having a diameter smaller than the diameter of said vessel. An implant assembly is released into a vessel such as a pulmonary arterial vessel of a patient. The implant assembly has a diameter smaller than or substantially equal to the inner diameter of the vessel and larger than the inner diameter of each of the sub-vessels. The implant assembly is configured so that it moves downstream within the vessel along with the flow of blood. When the implant assembly reaches a furcation where the vessel divides, the implant assembly is too large and not sufficiently compliant to fit through either of the smaller branch vessels. The implant assembly thus lodges at the furcation, prevented from moving downstream by being too large and stiff to fit into the branch vessels, and prevented from moving upstream by the flow of blood through the arteries.