Abstract: Devices, systems and methods are provided for treating aneurysms, particularly cerebral aneurysms. Such treatment is achieved minimally invasively without the need for conventional filling materials and methods. Such treatments may be used for aneurysms located near blood vessel side-branches and bifurcations.

Abstract: A stent graft assembly for use in placing a stent graft in a vessel of a patient comprising a balloon delivery catheter having a distal extremity and having an inflatable balloon on the distal extremity. A stent graft disposed over the inflatable balloon. The stent graft comprises a stent and a graft in the form of a polymeric sleeve extending over at least a portion of the graft. The graft has first and second ends. First and second expandable security rings are disposed over the first and second ends of the graft and serve to secure the first and second ends of the graft to the stent to prevent inadvertent displacement of the graft with respect to the stent during deployment of the stent graft into the vessel of the patient.

Abstract: A stent graft for implantation in a vessel in a human body comprising inner and outer concentric coaxial tubular sleeves formed of a flexible material compatible for use in the human body and each having first and second ends. A plurality of separate expandable metallic rings disposed axially within and between the inner and outer sleeves. Bands of a flexible material compatible with the flexible material utilized for the inner and outer sleeves disposed between the rings and within and between the inner and outer sleeves.

Abstract: A composite expandable device for delivery into a vessel carrying blood comprising an expandable support frame having first and second end portions. An impervious polymer sleeve having inner and outer surfaces extending over the support frame. A coating is disposed on at least one of the inner and outer surfaces of the polymer sleeve for enhancing endothelial cell growth on the device and polymer sleeve.

Abstract: A composite expandable device for delivery into a vessel carrying blood comprising an expandable support frame having first and second end portions. An impervious polymer sleeve having inner and outer surfaces extending over the support frame. A coating is disposed on at least one of the inner and outer surfaces of the polymer sleeve for enhancing endothelial cell growth on the device and polymer sleeve.

Abstract: A multi-step method for surface modification of a medical device having at least one surface exposed to tissue and/or blood. The steps comprise a low temperature plasma treatment of the said surface to provide a plasma deposited layer having functional groups. A chemical treatment of the plasma deposited layer using multifunctional linkers establishes covalent bonds with the plasma deposited layer. A bioactive/biocompatible agent react with the multifunctional linkers so that molecules thereof are covalently bound to said surface.

Abstract: An expandable stent having a radiopaque marker therein comprising a cylindrical member having a wall defining a central bore extending along a longitudinal axis and having inner and outer surfaces and a length. The wall has a pattern formed therein with openings extending therethrough into the bore. At least one radiopaque marker is carried by the wall and is disposed in an opening in the wall. The radiopaque marker is comprised of a framework formed in the wall and is disposed in an opening in the wall and lies within the confines of the wall. The framework is isolated from the pattern so that it does not interfere with the expansion of the expandable stent. The framework has an eyelet therein. An insert formed of a radiopaque material is disposed in the eyelet and retained in the framework and lies within the confines of and is flush with the inner and outer surfaces of the wall.

Abstract: A stent comprising a cylindrical member formed of metal and having a wall defining a bore extending therethrough along a longitudinal axis and having an inner surface and an outer surface. The wall has a pattern formed therein with openings extending therethrough into the bore. A coating containing silver is adherent to the outer surface of said wall for treatment of undesired conditions in the vessel.

Abstract: An expandable stent for deployment into a vessel having a lumen therein comprising a cylindrical member having a length and having proximal and distal extremities and being formed of a metal having a wall defining a central bore having a longitudinal axis extending from the proximal extremity to the distal extremity. The cylindrical member has an inside diameter and an outside diameter. The cylindrical member is formed of at least one cylindrical segment. The at least one cylindrical segment has a pattern formed therein which when the stent is expanded is capable of forming a truss formed of serially connected three-sided triangularly-shaped truss members. The pattern includes a first sinusoid extending circumferentially through 360.degree. about the longitudinal axis.