Patents Assigned to Cardiovascular Diagnostics, Inc.
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Publication number: 20070111271Abstract: A method, kit, system and reagent for measuring low molecular weight heparin in a whole blood sample is provided which involves the use of a Factor Xa activator, such as Russell's Viper Venom, as the coagulation assay initiator.Type: ApplicationFiled: January 29, 2007Publication date: May 17, 2007Applicant: CARDIOVASCULAR DIAGNOSTICS, INC.Inventor: Patrick Mize
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Publication number: 20040115753Abstract: A method, kit, system and reagent for measuring low molecular weight heparin in a whole blood sample is provided which involves the use of a Factor Xa activator, such as Russell's Viper Venom, as the coagulation assay initiator.Type: ApplicationFiled: November 26, 2003Publication date: June 17, 2004Applicant: CARDIOVASCULAR DIAGNOSTICS INC.Inventor: Patrick D. Mize
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Patent number: 6680177Abstract: A method, kit, system and reagent for measuring low molecular weight heparin in a whole blood sample is provided which involves the use of a Factor Xa activator, such as Russell's Viper Venom, as the coagulation assay initiator.Type: GrantFiled: December 7, 2001Date of Patent: January 20, 2004Assignee: Cardiovascular Diagnostics, Inc.Inventor: Patrick D. Mize
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Publication number: 20030124638Abstract: A method, kit, system and reagent for measuring low molecular weight heparin in a whole blood sample is provided which involves the use of a Factor Xa activator, such as Russell's Viper Venom, as the coagulation assay initiator.Type: ApplicationFiled: December 7, 2001Publication date: July 3, 2003Applicant: CARDIOVASCULAR DIAGNOSTICS, INC.Inventor: Patrick D. Mize
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Publication number: 20020119486Abstract: An element and method for easily performing liquid assays are disclosed. The element uses capillary action to draw a predetermined volume of a liquid sample into a reaction chamber charged with reagent, where reaction between the liquid sample and the reagent is monitored.Type: ApplicationFiled: March 6, 2002Publication date: August 29, 2002Applicant: CARDIOVASCULAR DIAGNOSTICS, INC.Inventor: Bruce Oberhardt
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Patent number: 6197494Abstract: An element and method for easily performing liquid assays are disclosed. The element uses capillary action to draw a predetermined volume of a liquid sample into a reaction chamber charged with reagent, where reaction between the liquid sample and the reagent is monitored.Type: GrantFiled: March 18, 1997Date of Patent: March 6, 2001Assignee: Cardiovascular Diagnostics, Inc.Inventor: Bruce Oberhardt
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Patent number: 6165795Abstract: A method of performing a fibrinogen assay is provided using an assay reagent containing ecarin to give an assay that is insensitive to the presence of heparin and insensitive to hematocrit, while being useful as a point of care assay in both a dry chemistry and wet chemistry format.Type: GrantFiled: June 25, 1998Date of Patent: December 26, 2000Assignee: Cardiovascular Diagnostics, Inc.Inventors: Patrick D. Mize, William B. Studabaker
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Patent number: 5677133Abstract: A method is described for performing an affinity assay comprising contacting a sample to be assayed for the presence of an analyte with a dry reagent containing the analyte (hapten, antigen, antibody, receptor, or complementary polynucleotide) bound to a reaction cascade initiator, an antibody or other binding pair partner reactive with said analyte, and magnetic particles, to form an assay mixture in a reaction chamber, incubating the assay mixture, applying an oscillating or moving static magnetic field to the assay mixture, activating the reaction cascade initiator to initiate a reaction cascade, monitoring the response of the magnetic particles to the oscillating or moving static magnetic field to provide a time varying signal, and determining the analyte concentration of the sample by analysis of the time varying signal, as well as a kit for performing the assay and a diagnostic system for performing the assay.Type: GrantFiled: September 11, 1996Date of Patent: October 14, 1997Assignee: Cardiovascular Diagnostics, Inc.Inventor: Bruce J. Oberhardt
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Patent number: 5670329Abstract: A method of performing a quantitative fibrinogen assay is provided which uses a dry reagent chemistry in combination with a rotational magnetic field and which has excellent correlation with the Fibrometer, the gold standard in the industry. Additionally, an apparatus for conducting the assay, a qualitative fibrinogen assay and a method for preparing a calibration curve for use with the quantitative fibrinogen assay are provided.Type: GrantFiled: May 28, 1993Date of Patent: September 23, 1997Assignee: Cardiovascular Diagnostics, Inc.Inventor: Bruce J. Oberhardt
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Patent number: 5658723Abstract: An analytical system for performing an immunoassay is provided wherein the system contains an element that uses capillary action to draw a sample into a reaction chamber charged with reagent containing an immobilized antibody or immobilized antigen, where reaction between the liquid sample and the reagent is monitored, and optionally contains a method for controlling the moment that transport of the sample from the sample well to the reaction chamber is initiated.Type: GrantFiled: May 23, 1994Date of Patent: August 19, 1997Assignee: Cardiovascular Diagnostics, Inc.Inventor: Bruce Oberhardt
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Patent number: 5601991Abstract: A method is described for performing an affinity assay comprising contacting a sample to be assayed for the presence of an analyte with a dry reagent containing the analyte (hapten, antigen, antibody, receptor, or complementary polynucleotide) bound to a reaction cascade initiator, an antibody or other binding pair partner reactive with said analyte, and magnetic particles, to form an assay mixture in a reaction chamber, incubating the assay mixture, applying an oscillating or moving static magnetic field to the assay mixture, activating the reaction cascade initiator to initiate a reaction cascade, monitoring the response of the magnetic particles to the oscillating or moving static magnetic field to provide a time varying signal, and determining the analyte concentration of the sample by analysis of the time varying signal, as well as a kit for performing the assay and a diagnostic system for performing the assay.Type: GrantFiled: February 13, 1995Date of Patent: February 11, 1997Assignee: Cardiovascular Diagnostics, Inc.Inventor: Bruce J. Oberhardt
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Patent number: 5508521Abstract: The invention is a Method and Apparatus for detecting the application of a liquid drop into a transparent reaction chamber or other reflecting surface in the presence of ambient light and transient motion of the chamber. A light source is modulated into two or more discrete levels at a fixed or variable modulation rate. These levels include an off level where there is no light from the optical source. Light from the source is specularly reflected into an optical detector which is sampled at least once for each modulated light level. Differences between modulated levels and the off level represent the amount of reflectivity of the surface or chamber. When liquid enters the chamber or is applied to the surface, the reflectivity changes. This leads to detectable changes between the modulated levels and the off level. Ambient light simply shifts the absolute values of the levels.Type: GrantFiled: December 5, 1994Date of Patent: April 16, 1996Assignee: Cardiovascular Diagnostics Inc.Inventors: Clifford H. Kraft, Gregory S. Godlevski, David T. Bach
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Patent number: 5350676Abstract: An apparatus and a method for performing a fibrinogen assay are disclosed. The reaction slide bears a sample well for receiving a liquid sample and a reaction chamber in fluid communication with the sample well. The reaction chamber contains a dry reagent matrix in which is embedded a plurality of magnetic particles. A whole blood or blood-derived sample added to the sample well is introduced simultaneously into the reaction chamber where it solubilizes the reagent, freeing the magnetic particles and allowing them to move in an oscillating pattern. This oscillating pattern is optically monitored to measure the concentration of clottable fibrinogen in the sample.Type: GrantFiled: May 17, 1993Date of Patent: September 27, 1994Assignee: Cardiovascular Diagnostics, Inc.Inventors: Bruce J. Oberhardt, Nancy Gresalfi
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Patent number: 5110727Abstract: A method and apparatus for the measurement of clot formation times, clot dissolution times, or clotting parameters is disclosed. This method performs these measurements by monitoring movement of magnetic particles incorporated in the sample being assayed, where the movement is induced by a magnetic field.Type: GrantFiled: May 10, 1988Date of Patent: May 5, 1992Assignee: Cardiovascular Diagnostics, Inc.Inventor: Bruce J. Oberhardt
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Patent number: 4849340Abstract: An element and method for easily performing liquid assays are disclosed. The element uses capillary action to draw a predetermined volume of a liquid sample into a reaction chamber charged with reagent, where reaction between the liquid sample and the reagent is monitored.Type: GrantFiled: April 3, 1987Date of Patent: July 18, 1989Assignee: Cardiovascular Diagnostics, Inc.Inventor: Bruce Oberhardt
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Patent number: D501678Type: GrantFiled: September 20, 2002Date of Patent: February 8, 2005Assignee: Cardiovascular Diagnostics, Inc.Inventor: Bruce Oberhardt