Abstract: A system and computer-implemented method for improving the quality of images, such as images used in medical diagnosis. In a first technique, sinogram data, intermediate volumes, and transmission CT-based attenuation correction files are created. Scatter correction is performed, and a scatter correction map is created. Misregistration offsets are measured, and a correction registration mask is created using volume reprojection. The two masks are combined and applied to create the enhanced image data. In a second technique, a difference may be determined for each parent and child pixel pair, and an average difference may be determined for all pairs. For each pair which is under the average difference, the child may be eliminated and replaced with a new child. This process may be iteratively repeated, with the image data being incrementally enhanced with each iteration. For both techniques, the enhanced image data may be communicated to an interpretive application for display.