Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
Type:
Grant
Filed:
January 19, 2011
Date of Patent:
October 2, 2012
Assignee:
Caris Life Sciences Luxembourg Holdings, S.A.R.L.
Inventors:
Michael Klass, Christine Kuslich, George Poste
Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
Type:
Grant
Filed:
January 19, 2011
Date of Patent:
July 3, 2012
Assignee:
Caris Life Sciences Luxembourg Holdings, S.A.R.L.
Inventors:
Michael Klass, Christine Kuslich, George Poste
Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
Type:
Grant
Filed:
December 8, 2010
Date of Patent:
June 5, 2012
Assignee:
Caris Life Sciences Luxembourg Holdings, S.A.R.L.
Inventors:
Michael Klass, Christine Kuslich, George Poste