Patents Assigned to Caris MPI, Inc.
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Publication number: 20140235511Abstract: Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.Type: ApplicationFiled: February 21, 2014Publication date: August 21, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
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Publication number: 20140221221Abstract: Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.Type: ApplicationFiled: February 7, 2014Publication date: August 7, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
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Publication number: 20140221222Abstract: Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.Type: ApplicationFiled: April 9, 2014Publication date: August 7, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
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Patent number: 8768629Abstract: Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.Type: GrantFiled: February 12, 2010Date of Patent: July 1, 2014Assignee: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, David M. Loesch, Arlet Alarcon, Robert J. Penny, Traci Pawlowski
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Publication number: 20140172319Abstract: Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.Type: ApplicationFiled: February 21, 2014Publication date: June 19, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
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Publication number: 20140156199Abstract: Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.Type: ApplicationFiled: February 7, 2014Publication date: June 5, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
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Publication number: 20140155298Abstract: Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.Type: ApplicationFiled: February 7, 2014Publication date: June 5, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
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Publication number: 20140149137Abstract: Provided herein are methods and systems for identifying a therapeutic for an individual, such as a therapeutic not previously identified for treating the individual. The therapeutic can be identified by molecular profiling, such as determining the biomarker patterns or signature sets of a biological sample of an individual.Type: ApplicationFiled: January 31, 2014Publication date: May 29, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, Robert J. Penny
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Publication number: 20140149136Abstract: Provided herein are methods and systems for identifying a therapeutic for an individual, such as a therapeutic not previously identified for treating the individual. The therapeutic can be identified by molecular profiling, such as determining the biomarker patterns or signature sets of a biological sample of an individual.Type: ApplicationFiled: January 31, 2014Publication date: May 29, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, Robert J. Penny
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Publication number: 20140149138Abstract: A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.Type: ApplicationFiled: January 31, 2014Publication date: May 29, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, Robert J. Penny
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Publication number: 20140121121Abstract: A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.Type: ApplicationFiled: January 8, 2014Publication date: May 1, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, Robert J. Penny
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Publication number: 20140113837Abstract: A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.Type: ApplicationFiled: December 30, 2013Publication date: April 24, 2014Applicant: CARIS MPI, INC.Inventors: Daniel D. Von Hoff, Robert J. Penny
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Patent number: 8700335Abstract: A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.Type: GrantFiled: May 18, 2007Date of Patent: April 15, 2014Assignee: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, Robert Penny
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Publication number: 20140057986Abstract: Provided herein are methods and systems for identifying a therapeutic for an individual, such as a therapeutic not previously identified for treating the individual. The therapeutic can be identified by molecular profiling, such as determining the biomarker patterns or signature sets of a biological sample of an individual.Type: ApplicationFiled: November 1, 2013Publication date: February 27, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, Robert J. Penny
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Publication number: 20140038846Abstract: A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.Type: ApplicationFiled: October 11, 2013Publication date: February 6, 2014Applicant: Caris MPI, Inc.Inventors: Daniel D. Von Hoff, Robert J. Penny
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Patent number: 7888035Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.Type: GrantFiled: October 30, 2009Date of Patent: February 15, 2011Assignee: Caris MPI, Inc.Inventors: Michael Klass, Christine Kuslich, George Poste
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Publication number: 20100203529Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: February 5, 2010Publication date: August 12, 2010Applicant: Caris MPI, Inc.Inventors: Christine Kuslich, George Poste, Michael Klass
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Publication number: 20100184046Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: November 12, 2009Publication date: July 22, 2010Applicant: Caris MPI, Inc.Inventors: Michael Klass, Christine Kuslich, George Poste
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Publication number: 20100113290Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.Type: ApplicationFiled: October 30, 2009Publication date: May 6, 2010Applicant: Caris MPI, Inc.Inventors: Michael KLASS, Christine Kuslich, George Poste