Patents Assigned to Caris Science, Inc.
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Patent number: 11725023Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.Type: GrantFiled: February 3, 2021Date of Patent: August 15, 2023Assignee: Caris Science, Inc.Inventors: Heather O'Neill, Günter Mayer, Mark Miglarese, David Spetzler
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Patent number: 11624083Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.Type: GrantFiled: June 13, 2022Date of Patent: April 11, 2023Assignee: Caris Science, Inc.Inventors: Clive Gavin Brown, Koen Kas, Sven Agnes Jan Eyckerman
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Patent number: 11332748Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: GrantFiled: June 10, 2020Date of Patent: May 17, 2022Assignee: Caris Science, Inc.Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
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Patent number: 11293017Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: GrantFiled: May 25, 2017Date of Patent: April 5, 2022Assignee: Caris Science, Inc.Inventors: Valeriy Domenyuk, Tassilo Hornung, Mark Miglarese, David Spetzler
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Patent number: 11091765Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.Type: GrantFiled: February 6, 2020Date of Patent: August 17, 2021Assignee: Caris Science, Inc.Inventors: Heather O'Neill, Mark Miglarese, David Spetzler
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Patent number: 10995360Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.Type: GrantFiled: May 8, 2019Date of Patent: May 4, 2021Assignee: Caris Science, Inc.Inventors: Clive Gavin Brown, Koen Kas, Sven Agnes Jan Eyckerman
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Patent number: 10941176Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.Type: GrantFiled: July 28, 2016Date of Patent: March 9, 2021Assignee: Caris Science, Inc.Inventors: Heather O'Neill, Günter Mayer, Mark Miglarese, David Spetzler
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Patent number: 10942184Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.Type: GrantFiled: March 6, 2018Date of Patent: March 9, 2021Assignee: Caris Science, Inc.Inventors: David D. Halbert, Valeriy Domenyuk, David Spetzler, Tassilo Hornung, Frank Schafer, Nianqing Xiao
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Publication number: 20200376022Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include circulating biomarkers such as micro vesicles, including those derived from various diseases.Type: ApplicationFiled: March 27, 2018Publication date: December 3, 2020Applicant: Caris Science, Inc.Inventors: Valeriy Domenyuk, Xianghua Liu, Mark Miglarese, David Spetzler
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Publication number: 20200270610Abstract: Methods and compositions are provided for oligonucleotide probes and oligonucleotide probe libraries that recognize targets of interest. The targets include circulating biomarkers such as microvesicles, including those derived from various diseases.Type: ApplicationFiled: November 25, 2019Publication date: August 27, 2020Applicant: Caris Science, Inc.Inventors: Valeriy DOMENYUK, Adam STARK, Nianqing XIAO, Zhenyu ZHONG, Mark MIGLARESE, David SPETZLER
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Patent number: 10731166Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: GrantFiled: March 18, 2017Date of Patent: August 4, 2020Assignee: Caris Science, Inc.Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
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Patent number: 10590425Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.Type: GrantFiled: June 29, 2016Date of Patent: March 17, 2020Assignee: Caris Science, Inc.Inventors: Heather O'Neill, Mark Miglarese, David Spetzler
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Patent number: 10316349Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.Type: GrantFiled: August 4, 2017Date of Patent: June 11, 2019Assignee: Caris Science, Inc.Inventors: Clive Gavin Brown, Koen Kas, Sven Agnes Jan Eyckerman