Abstract: A system of compensating a medical image to make it look like it came from either a different camera or from using a different dye or stain. The medical image is obtained and then processed using characteristics of the non-image related parts of the image. These non-image related parts can include the dye that was used to dye the image or the camera that was used to obtain the image. Then, the raw or partially raw image can be reprocessed using characteristics of the different non-image related part. For example, in one embodiment, the image is deconvolved to remove the influence of the camera that actually obtained the image, then reconvolved with information indicative of a different camera. In this way, the image is processed to make it look like it came from a different camera than the one that actually did in fact form it.

Abstract: A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders.

Abstract: A method and system for creating a digital, virtual slide having optimum image quality characteristics. Multiple regions of a physical slide are identified as well as at least two focus z-positions z1, and z2. Each region of the physical slide is scanned (imaged) at the first z position, so as to produce a first set of digital images of each defined region. Each region of the physical slide is also scanned (imaged) at the second z position, so as to produce a second set of digital images of each defined region. Each image of each set is evaluated against a focus quality metric and, for each region, either the first or second image, corresponding to that region, is selected that exhibits a focus quality metric corresponding to a desired focus quality. These images are then merged into a digital virtual slide. Additional focus z-positions may be included, and the multiple z-positions may be scanned seriatim, sequentially, and/or in overlapping fashion.

Abstract: A remote view station is communicatively coupled to an image server and receives a compressed version of source medical images. The remote view station uncompresses and displays the received medical image. A medical professional, such as a pathologist, can select a region of the displayed medical image. Region information is transmitted back to the image server that applies image analysis operations on a region of the source medical image that corresponds to the selected region of the compressed medical image. In this manner, the data loss that occurs during image compression does not effect the image analysis operations. As such, the image analysis operations produce more accurate results than if the operations were applied by remote view station to the uncompressed image.

Abstract: A system and method for reconstructing a diagnostic trajectory.

Abstract: The apparatus and method of the invention provide for assigning coordinates to samples in an array. The method is based on a hierarchical pattern matching to a local lattice structure that is used as a template. Starting from the best local match, the pattern is expanded hierarchically to encompass the entire array.

Abstract: A method and system for creating a digital, virtual slide having optimum image quality characteristics. Multiple regions of a physical slide are identified as well as at least two focus z-positions z1, and z2. Each region of the physical slide is scanned (imaged) at the first z position, so as to produce a first set of digital images of each defined region. Each region of the physical slide is also scanned (imaged) at the second z position, so as to produce a second set of digital images of each defined region. Each image of each set is evaluated against a focus quality metric and, for each region, either the first or second image, corresponding to that region, is selected that exhibits a focus quality metric corresponding to a desired focus quality. These images are then merged into a digital virtual slide. Additional focus z-positions may be included, and the multiple z-positions may be scanned seriatim, sequentially, and/or in overlapping fashion.

Abstract: A method of providing remote navigation of a specimen includes receiving a command to remotely control a microscope and a camera coupled with the microscope to view a portion of a specimen disposed on the microscope, capturing a digital image of the portion with the camera in response to the command, representing the digital image as a plurality of digital image components, each of the digital image components providing a different level of detail of the image, and transmitting the components in sequential order of increasing level of detail from least detailed to most detailed.

Abstract: A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then filtered. The candidate interest pixels are morphologically processed and compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.

Abstract: A system for determining tissue locations on a slide.

Abstract: A system, device, and method for analyzing cellular specimen slides for observable pathologies, including presenting a first image of a first slide including a first portion of a cellular specimen, wherein the first portion is stained with a first stain, initiating an automated randomization sequence, wherein one or more regions of the first image are randomly selected and presented, and effecting analysis of the first image at each of the one or more regions to determine whether each of the one or more regions includes an area of interest.

Abstract: A system and method for remote navigation of a specimen.

Abstract: An automated method for evaluating the amount of residual protein levels following treatment of cellular specimens. Particular methods include the measurement of maternal neutrophil alkaline phosphatase after treatment with or without urea or heat, measurement of leukocyte acid phosphatase after treatment with or without tartrate, and measurement of leukocyte esterase after treatment with ?-naphthol butyrate with or without fluoride.

Abstract: A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then low pass filtered and compared to a threshold to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed to group candidate object of interest pixels together into groups which are compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.

Abstract: Disclosed is an automated staining apparatus (autostainer) capable of staining sample on a microscope slide. The autostainer is capable of limiting the amount of reagent used through a process including image acquisition and processing techniques, wherein an image of the slide is acquired and used to determine a region on the slide to be stained. Also disclosed are methods of using images acquired by the autostainer in sample processing. In addition, a system having the autostainer functionally linked to an imaging system is provided.