Abstract: The present disclosure relates generally to the selection of DNA aptamers that prevent aggregation, or fibrilization of alpha-synuclein protein. The aptamers described herein are of use as a therapeutic tool to prevent protein aggregation in neurodegenerative disease.

Abstract: A delay cell for use in a voltage controlled oscillator includes a differential amplifier having a pair of outputs, a common source resistive element supplying current to said differential amplifier, a varactor arrangement between the outputs having a control input, and a pair of load resistive elements connected to the respective outputs. The delay cell has a simple design, a small die area, low power dissipation, constant amplitude of oscillation versus control voltage, and a Figure of Merit (FOM) comparable to that of LC oscillators.

Abstract: A method of determining scenario causality, along with precedence causality, is disclosed. Information is recorded relating to events occurring during execution of a process. The information includes object related information and process related information. The information is translated into a sequence of scenario graph language statements, one or more events translated to a statement. From the statements, process execution flow is determined establishing some scenario causality and precedence causality.

Abstract: Functionalized derivatives of benzocyclobutenone of formula I and II herein are photoreactive and may be employed in the production of a variety of self-curable polymer composition which may be employed as photoresist compositions, pressure sensitive adhesives, hot melt adhesives and sealants; the polymer compositions may be cured or cross-linked by UV or Vis radiations.

Abstract: The invention presents an approach that uses plural separated foils to shape an ion beam so that the intensity density of hot spots in the ion beam is lowered. More particularly, plural foils are placed in close proximity to each other, wherein at least one foil intercepts a portion of the beam to strip a charge from ions in different portions of the beam at different times, and thus, shape the ion beam. At a basic level, the inventive approach places plural foils so that the distance between planes of successive foils is a fraction of the radius of curvature of the beam's cyclotron orbit.

Abstract: An insulated gate field effect transistor dosimeter has a source and drain defining a channel region, a floating gate having a first portion extending over the channel region, and a second, larger portion extending away from said region, a control gate having at least a portion thereof overlapping a first part of the floating gate, and a charging gate overlapping a second part of the floating gate. The area of the second part of the floating gate is much smaller than the area of the first part, and the charging gate is separated from the channel region by the control gate. The dosimeter is charged, before irradiation, by connecting the source, drain and control gate to a common ground and applying a potential difference between the charging gate and the common ground. The charge is supplied to the floating gate by a path which does not require a significant electric stress to be created in the region of the gate oxide and the channel.

Abstract: A low voltage silicon bipolar RF (radio frequency) receiver front end includes a low noise preamplifier and double-balanced mixer. The receiver incorporates monolithic microstrip transformers for significant improvements in performance compared with silicon broadband designs. Reactive feedback and coupling elements are used in place of resistors to lower the front end noise figure through the reduction of resistor thermal noise, and this also allows both circuits to operate at supply voltages below 2 volts. Circuits fabricated using 0.8 .mu.m Bipolar CMOS technology provide a peak npn transistor transit frequency f.sub.T of 11 GHz. At a supply voltage of 1.9 volts, the measured input third order intercept point is +2.3 dBm with a 10.9 dB single-sideband noise figure. Power dissipated is less than 5 mW. The low noise amplifier input intercept is -3 dBm with a 2.8 dB noise figure and 0.5 dB gain. Power dissipation of the preamplifier is less than 4 mW from a 1.9 V supply.

Abstract: The invention disclosed relates to novel functionalized benzocyclobutenones of structural formula I ##STR1## wherein R is NH.sub.2, reactive NH.sub.2 derivatives including acids, acid chlorides, amides and diazonium salts, OH, CN, NO.sub.2, H, I, F Br, Cl, mercapto and deuterium. Also disclosed are polymer compositions comprising thermal reaction products of the benzocyclobutenones of formula I and either a polyol or a polyamine.

Abstract: A device for immunological techniques is prepared containing a macroporous hydrophobic synthetic polymer cloth having antibodies or antigens directly adsorbed therein and directly absorbed and immobilized thereon. The cloth has a thickness of more than about 200 .mu.m and has spaces between fibres exceeding about 20 .mu.m in diameter, and preferably has a Frazier Air permeability, in CFM/ft.sup.2 at 0.5" H.sub.2 O of from about 215 to about 750 for thickness of from about 11 to about 40 mils such that it can accommodate a large volume of liquid per surface area, that it has a large surface area, and that it has minimum flow resistance. In immunoassays antibodies may be directly adsorbed therein and directly absorbed and immobilized thereon, and specific antigens from a selected test sample, may then be captured by the antibodies, to be detected conventionally.

Abstract: A method of operating a telescope is provided herein for a telescope having an eyepiece. The method uses a graphics display having a data base of celestial bodies, and means for generating and displaying a graphics display comprising graphics artefacts, each representing an associated celestial body. The method includes the first step of correlating, as a datum, the position of that telescope and the position of that graphics display corresponding to the field of view of the telescope. The second step involves displacing that graphics display or the position of the telescope to show an artefact representing a celestial body of interest. The third step involves detecting the effective distance moved in such displacing step.

Abstract: An immunoassay device containing an immobilized antibody or antigen is provided by directly absorbing and absorbing an unmodified antibody or antigen on and within a woven or non-woven macroporous hydrophobic synthetic polymer cloth formed of a synthetic polymer selected from the group consisting of plypropylene, polyester, nylon and polyethylene. The cloth has a thickness of more than about 200 .mu.m and contains pores in the form of spaces between fibers exceeding about 20 .mu.m in diameter, and has a Frazier Air Permeability in CFM/ft.sup.2 at 0.5" H.sub.2 O of about 215 for a cloth of thickness of about 40 mils. The cloth has a large surface area for binding to an antibody or antigen and can accommodate a large volume of liquid per surface area and has minimum flow resistance.

Abstract: An indirect frequency synthesizer suitable for use in a cellular radio system has finer resolution and reduced spurious frequencies and/or phase noise, which facilitates a large number of channels in a given bandwidth. The synthesizer comprises a phase detector responsive to a reference signal and a phase control signal for generating a control signal that varies in dependence upon the phase difference between the reference signal and the phase control signal. A voltage controlled oscillator responsive to the control signal generates an output signal whose frequency varies in dependence upon the control signal. A variable modulus divider divides the output signal to provide the phase control signal. The variable modulus divider varies its division ratio in dependence upon a ratio control signal derived by a second or higher order sigma-delta modulator in response to a frequency control signal .delta..phi. and to the phase control signal.