Patents Assigned to Carlsberg Laboratory
  • Modified carboxypeptidase
    Patent number: 5985627
    Abstract: A method for transamidating a peptide substrate having a P.sub.1 amino acid residue with a positively charged side chain. According to the invention, carboxypeptidase Y is modified to substitute at least one amino acid having a negatively charged side chain in an S.sub.1 subsite. Additionally, the modified carboxypeptidase Y can include substituted amino acid residues in an S.sub.1 ', S.sub.2 and/or S.sub.3 subsite to accommodate a specific peptide substrate.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: November 16, 1999
    Assignee: Carlsberg Laboratory
    Inventors: Uffe Mortensen, Kjeld Olesen, Henning Stennicke, Steen B. S.o slashed.rensen, Klaus Breddam