Patents Assigned to Carnegie Melton
  • Stabilized Stat3 Decoy Oligonucleotides And Uses Therefor
    Publication number: 20120288536
    Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
    Type: Application
    Filed: June 7, 2012
    Publication date: November 15, 2012
    Applicants: Carnegie Melton, University of Pittsburgh - Of The Commonwealth System of Higher Education
    Inventors: Jennifer R. Grandis, Daniel Johnson, Danith Ly