Patents Assigned to CAROLUS THERPEUTICS, INC.
  • METHODS OF TREATING INFLAMMATION
    Publication number: 20110262386
    Abstract: Disclosed herein, in certain embodiments, is a method for treating an MIF-mediated disorder. In some embodiments, the method comprises administering an active agent that inhibits (i) MIF binding to CXCR2 and CXCR4 and/or (ii) MIF-activation of CXCR2 and CXCR4; (iii) the ability of MIF to form a homomultimer; or a combination thereof.
    Type: Application
    Filed: March 20, 2009
    Publication date: October 27, 2011
    Applicant: CAROLUS THERPEUTICS, INC.
    Inventors: Jürgen Bernhagen, Joshua Robert Schultz, Benedikt Vollrath, Alma Zernecke, Christian Weber
  • METHODS AND COMPOSITIONS FOR TREATING ATHEROSCLEROSIS AND RELATED CONDIDTIONS
    Publication number: 20110070184
    Abstract: Described herein are methods for treating or preventing a atherosclerosis by inhibiting the activation or binding of macrophage migration inhibitory factor to CXCR2 and CXCR4. Such inhibition is achieved by administration of either a single agent or a combination of agents. Also described herein are agents that inhibit MIF-binding or MIF-activation of CXCR2 or CXCR4. Further described are pharmaceutical compositions comprising such agents and their use for treating or preventing atherosclerosis.
    Type: Application
    Filed: March 24, 2008
    Publication date: March 24, 2011
    Applicant: CAROLUS THERPEUTICS, INC.
    Inventors: Jürgen Bernhagen, Christian Weber, Alma Zernecke
  • METHODS OF TREATMENT USING ANTI-MIF ANTIBODIES
    Publication number: 20110044988
    Abstract: Disclosed herein, in certain embodiments, is a method for treating an inflammatory disorder. In some embodiments, the method comprises administering an active agent that inhibits (i) MIF binding to CXCR2 and CXCR4 and/or (ii) MIF-activation of CXCR2 and CXCR4; (iii) the ability of MIF to form a homomultimer; or a combination thereof.
    Type: Application
    Filed: March 20, 2009
    Publication date: February 24, 2011
    Applicant: CAROLUS THERPEUTICS, INC.
    Inventors: Jürgen Bernhagen, Joshua Robert Schultz, Benedikt Vollrath, Alma Zernecke, Christian Weber