Abstract: A mobile radiography apparatus has a moveable (e.g., wheeled) transport frame and an adjustable column mounted at the frame. A boom apparatus supported by the adjustable column can support an x-ray source assembly. Certain exemplary methods and/or apparatus embodiments can provide mobile radiography carts a capability to direct x-ray radiation towards a subject from one or a plurality of different source positions, and reconstruct two-dimensional or three-dimensional tomosynthesis images where an imaging geometry of x-ray source positions to a radiographic detection array is not known for a plurality of x-ray tomosynthesis projection images. In one embodiment, an imaging geometry and tomosynthesis reconstruction(s) can be simultaneously determined by iteratively determining a current imaging geometry while iteratively monitoring a metric (e.g., stopping criterion) that approaches a prescribed or desired value associated with the tomosynthesis reconstruction.