Abstract: A medical guide wire torquer is disclosed which is adapted for one-handed convenient attachment, release, and re-attachment to a medical guide wire utilized during medical procedures. The guide wire torquer has a body having ends and positioners integral or affixed to each end, a first channel, and an internal cavity. At least one elastomer is positioned within the internal cavity. A button is positioned within the cavity for engagement to the elastomer where the button extends beyond the body. The button includes a pair of retainers adapted for engagement to the positioners and a second channel adapted for alignment with the first channel during the release of a guide wire. A guide wire is releasably grasped by the vertical movement of the button within the cavity which causes the expansion of the elastomers which, in turn, results in a binding of the guide wire between the first and second channels.