Abstract: The present disclosure provides therapeutic methods of treating a cancer patient with a vinca alkaloide N-oxide and an immune checkpoint inhibitor.

Abstract: An article of manufacture includes an inflatable body comprising a first core member cut from a single slab of core material and a second core member cut from the single slab of core material and coupled to the first core member.

Abstract: In one embodiment of the present disclosure, an attachment assembly for coupling to a base plate includes a substantially planar attachment plate having a top side and a bottom side, a magnet assembly including at least three magnets, each of the at least three magnets having a first side and a second side opposite the first side, the first sides of the at least three magnets are configured for coupling with the bottom side of the attachment plate, wherein the at least three magnets each have a first end and a second end, such that the first end of each magnet is adjacent a second end of an adjacent magnet to form an array, and a shim plate removably coupled to the second side of the at least three magnets.

Abstract: The invention relates generally to compound planet gear arrangements for transmitting torque between two rotating shafts, by splitting the torque into several torque transmitting gear components. The gear arrangements may contain gear shifts arrangement and free-wheel arrangements. The invention also relates to gear wheel arrangements having enhanced torsional compliance capabilities, which gear wheel arrangements advantageously may be used in said compound planet gear arrangements and also at other applications such as at other over-determined systems or where intermittent loads and forces occur. According to one aspect, the invention relates to a gear wheel arrangement (700, 800, 900), comprising; a first part (710, 810, 910) which is arranged to be rotationally fixed to a shaft; a second part (720, 820, 920) which is rotatably connected to the first part and provided with gear teeth for meshing with an adjacent gear.

Abstract: A sports glove, such as a lacrosse glove or a hockey glove, for a player or other wearer. The sports glove comprises a hand covering for protecting a hand of the wearer. The hand covering comprises protective padding. The hand covering comprises a palm portion for overlying a palm of the wearer's hand, a back portion for overlying a back of the wearer's hand, finger portions for receiving fingers of the wearer's hand, and a thumb portion for receiving a thumb of the wearer's hand. The sports glove comprises a cuff for overlying a wrist of the wearer. The cuff comprises protective padding. The cuff is adjustable. For example, the cuff may be flared relative to the hand covering and configured such that a flare of the cuff is adjustable.

Abstract: Resilient cores preferably for inflatable bodies having resilient slabs that define a plurality of generally columnar holes or resilient arrays of generally columnar solids, methods for making such slabs and arrays, and articles incorporating the same wherein the cores further includes thermal transmission mitigation means for improving a core's resistance to heat transfer beyond the core's innate insulative properties. Non-exclusive and non-exhaustive examples of such thermal transmission mitigation means in slab core embodiments include consideration to hole or bore geometric cross section, frequency, pattern and orientation, the introduction of a thermal barrier at or within at least some holes or bores, and/or slab material selection/treatment.

Abstract: A protector for protecting an arm or other body part of a wearer, such as a sports player playing lacrosse, hockey, baseball, or another sport. The protector comprises: a base for engaging the wearer's arm or other body part; and a pad member fastened to the base and comprising protective padding. The pad member may be fastened to the base by a narrow fastening zone. This may allow the protector to better fit on the wearer's arm or other body part, reduce resistance to movement of the wearer's arm or other body part, and/or increase breathability or ventilation of the wearer's arm or other body part and the protector itself.

Abstract: Disclosed is a method for producing a metal borohydride and/or H2, including: A. producing a metal borohydride in a synthesis process, in which H2 is a reactant and the reaction further takes metal hydroxide and boron oxide or further takes metal boron oxide; B. producing H2 in a chemical reaction process, in which metal borohydride produced in step A and H2O are reactants, the amount of H2 produced in step B being larger than the amount of H2 required as a reactant in step A for the same amounts of metal borohydride as a reactant and a reaction product in steps B and A, respectively; and C. providing H2 produced in step C to step A, and repeating steps A, B and C. Part of the metal borohydride and/or H2 is withdrawn while leaving an amount of metal borohydride and H2, respectively, so as to allow repeating steps A-C.

Abstract: A joint to connect frame members to form a frame of a chair. The joint has a first receptacle to receive a leg in a first position in which the leg extends in a first direction to support the frame of the chair at a distance above a surface, the leg attached to the frame via a cord. The joint has a second receptacle to receive the leg in a second position in which the leg extends in a second direction, opposite to the first direction, so that the joint rests on the surface, the second receptacle having an axially-oriented slot along a sidewall thereof to allow the cord to pass through into a central portion of the second receptacle.

Abstract: A lockable bollard to be anchored into the ground includes a substantially vertical post that is rectangular in cross section, with a base having a base fastening structure extending downwardly to be anchored into the ground to which the post is to be anchored. A control shaft extends substantially the entire length of the post, the control shaft having an operating handle adjacent a top end and having a lower engagement feature adjacent a bottom end designed to selectively engage the base when the shaft is in a predetermined position. A closure is disposed adjacent the top of the post to permit selective access to the operating handle.

Abstract: A laser detection system comprises a plurality of lasers wherein each laser is configured to produce a respective laser beam for excitation of one or more different compounds, a sample cell for containing a volume of sample gas, at least one directing device configured to direct the laser beams to the sample cell, wherein the at least one directing device is configured to direct the laser beams along a common optical path to the sample cell, and a detector apparatus for detecting light output from the cell.

Abstract: The invention relates generally to compound planet gear arrangements for transmitting torque between two rotating shafts, by splitting the torque into several torque transmitting gear components. The gear arrangements may contain gear shifts arrangement and free-wheel arrangements. The invention also relates to gear wheel arrangements having enhanced torsional compliance capabilities, which gear wheel arrangements advantageously may be used in said compound planet gear arrangements and also at other applications such as at other over-determined systems or where intermittent loads and forces occur. According to one aspect, the invention relates to a gear wheel arrangement (700, 800, 900), comprising; a first part (710, 810, 910) which is arranged to be rotationally fixed to a shaft; a second part (720, 820, 920) which is rotatably connected to the first part and provided with gear teeth for meshing with an adjacent gear.

Abstract: The present disclosure generally relates to an insulating device, for example a cooler, and a latch and latching system for securing a lid of the insulating device in a closed position. More specifically, the insulating device includes a chest coupled to a lid, and a ledge extending from the chest. A slot is formed in the ledge and for each slot, a pair of protrusions extend from a bottom surface of the ledge on other side of the slot. The protrusions are received by corresponding recesses formed in the latch. Thus, when the latch is in the engaged position, the protrusions are physically securely engaged in the recesses by virtue of the latch being in a tensioned configuration.

Abstract: The present disclosure relates to thermal contrast therapy devices, treatment methods for providing thermal contrast therapy, and systems for providing and managing thermal contrast therapy treatments. The thermal contrast therapy devices disclosed herein are configured to provide a sequence of alternating cooling periods and heating periods to one or more areas of a patient's body. A thermal contrast therapy device may comprise a source of hot fluid, a source of cold fluid, and one or more pumps configured to circulate fluid through one or more treatment pads in fluid communication with the device. The thermal contrast therapy devices disclosed herein are configured to rapidly and efficiently transition between alternating cooling periods and heating periods.

Abstract: A leak detection system for detecting leaks in pressurized containers, the system comprising a leak test conveyor for moving each container and an accumulation tunnel through which the leak test conveyer extends, wherein the accumulation tunnel and the leak test conveyer together define at least one enclosed accumulation volume, each enclosed accumulation volume being sized to accommodate only a single container, thereby to allow gas leaking from the single container to accumulate, and a gas sensor for sensing accumulated leaked gas from the single container.

Abstract: A portable liquid-filtration device includes an inlet port, a filtering portion including a filtering medium and fluidly coupled to the inlet port, a filtered-liquid output port fluidly coupled to the filtering portion, a flush port fluidly coupled to the filtering portion, and a manually activated pump assembly fluidly coupled to the inlet port, filtering portion, output port and flush port. The pump assembly is configured, when activated, to create a negative fluid pressure at the inlet port and a positive fluid pressure at the output port and the flush port. As a consequence of activation of the pump assembly, the filtering portion receives unfiltered liquid from the inlet port, the output port receives from the filtering portion only liquid traversing the filtering medium in a first direction, and the flush port receives from the filtering portion liquid traversing the filtering medium in a second direction different from the first direction.

Abstract: A helmet having a chin bar fastened at two points on each side of the shell. The shell is molded with recessed portions designed to receive the two branches of the chin bar on each side where they will be fastened to the shell so that the outer surfaces of the chin guard are flush with the shell at the locations of attachment to provide a smooth transition and reduce weight. An adjustment device to adjust the fit of the helmet to the user includes a star wheel on each side of the helmet attached to an arcuate flexible strip extending rearwardly around the occipital area of the skull. A sliding mechanism attached to the strip allows the strip to be moved forward and backward to allow it to be tightened or loosened, respectively, with respect to the player's head. A ratcheting lateral adjustment device is also disclosed.

Abstract: An optical cell comprises first and second opposed reflecting elements, an entrance aperture in the first reflecting element and an exit aperture in the second reflecting element, wherein the entrance and exit apertures are configured such that, in operation, light introduced into the cell via the entrance aperture is reflected at least once by the second reflecting element and at least once by the first reflecting element before leaving the cell via the exit aperture.

Abstract: Shoulder pads for a player playing a contact sport, such as hockey, lacrosse or football, are provided. The shoulder pads comprise a front member, a back member, left and right shoulder arches, left and right shoulder protectors, and an adjustment system allowing the player to adjust a fit of the shoulder pads. The adjustment system may allow the player to adjust various components of the shoulder pads, including the front member, the back member, and the left and right shoulder protectors, in various directions.